Abstract: An apomorphine pharmaceutical dosage security system embodied in multiple dosage forms including oral dosage forms, transdermal delivery patches, nasal delivery forms, and transdermal dosage forms. Within the present invention is an amount of apomorphine adapted to be bioavailable to a degree sufficient to cause emesis or severe nausea when an overdose amount of a therapeutic agent enters systemic circulation.

Abstract: A secured transdermal delivery system, applicable to both matrix and reservoir patches, for preventing misuse of medications embedded within and affixed to transdermal patches. The secured transdermal delivery system includes a backing supporting a pharmaceutical composition and one or more security agents adapted to modify the pharmacophore of the pharmaceutical composition. The security agent is separated from the pharmaceutical composition by one or more dissolving security layers which define one or more security reservoirs within the patch.