Patents by Inventor John Trainor Gray

John Trainor Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of factor IX in gene therapy vectors
    Patent number: 8168425
    Abstract: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used to express Factor IX, as well as any other gene of interest, in a size-constrained environment such as in a self complementary gene therapy vector system.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: May 1, 2012
    Assignee: St. Jude Children's Research Hospital
    Inventor: John Trainor Gray
  • EXPRESSION OF FACTOR IX IN GENE THERAPY VECTORS
    Publication number: 20110287532
    Abstract: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used to express Factor IX, as well as any other gene of interest, in a size-constrained environment such as in a self complementary gene therapy vector system.
    Type: Application
    Filed: August 4, 2011
    Publication date: November 24, 2011
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventor: John Trainor Gray
  • Expression of factor IX in gene therapy vectors
    Patent number: 8030065
    Abstract: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used to express Factor IX, as well as any other gene of interest, in a size-constrained environment such as in a self complementary gene therapy vector system.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: October 4, 2011
    Assignee: St. Jude Children's Research Hospital
    Inventor: John Trainor Gray
  • Expression of Factor Ix in Gene Therapy Vectors
    Publication number: 20080153156
    Abstract: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used to express Factor IX, as well as any other gene of interest, in a size-constrained environment such as in a self complementary gene therapy vector system.
    Type: Application
    Filed: September 9, 2005
    Publication date: June 26, 2008
    Inventor: John Trainor Gray