Patents by Inventor John Underwood
John Underwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250019262Abstract: The present invention relates to a method of determining the total organic carbon content (TOC) of a purified water stream in a water purification apparatus having at least a first pump, a first conductivity sensor, an oxidiser, and an oxidiser recirculation circuit having a dedicated second pump, the method comprising at least the steps of: (a) using the first pump to pass a water supply stream through the water purification apparatus, including through the first conductivity sensor and the oxidiser, to provide a purified water stream available for dispense; (b) using the first conductivity sensor to measure a first conductivity value of the water supply stream prior to the oxidiser; (c) stopping the first pump; (d) using the second pump in the oxidiser recirculation circuit to recirculate the water in the oxidiser only through the first conductivity sensor and the oxidiser a plurality of times, (e) using the first conductivity sensor to measure a second conductivity value of the recirculated water; and (Type: ApplicationFiled: July 28, 2022Publication date: January 16, 2025Inventors: John Walker, Craig Stephen Over, Lee Underwood, Peter Bower
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Publication number: 20240309616Abstract: There is described a securing device for releasably securing a first object to a second objection. The device comprises a casing and a coupling magnet housed in the casing. The casing is configured for being inserted in a passageway formed by aligned openings of the first and second objects when assembled together, for blocking separation of the first object and the second object from one another. The coupling magnet is moveable from an initial position to a working position to form a magnetic coupling for holding the casing in the passageway. The first and second objects can respectively be a tooth of a mining or excavation bucket and an adaptor of the bucket for the tooth. A fixed magnet can be provided in the casing, the fixed magnet being oppositely poled with respect to the coupling magnet for damping the movement of the coupling magnet to its working position. There is also provided a removal tool for removal of the securing device from its securing position.Type: ApplicationFiled: May 21, 2024Publication date: September 19, 2024Inventor: Perry John Underwood
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Patent number: 12011481Abstract: The instant disclosure provides antibodies that specifically bind to TIM 3 and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: GrantFiled: January 12, 2021Date of Patent: June 18, 2024Assignee: AGENUS INC.Inventors: Marc van Dijk, Ekaterina Vladimirovna Breous-Nystrom, Nicholas Stuart Wilson, Jeremy Dale Waight, Dennis John Underwood
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Publication number: 20240181048Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: ApplicationFiled: October 26, 2023Publication date: June 6, 2024Inventors: Marc VAN DIJK, Ekaterina Vladimirovna BREOUS-NYSTROM, Nicholas Stuart WILSON, Jeremy Dale WAIGHT, Dennis John UNDERWOOD
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Patent number: 12000119Abstract: There is described a securing device (10) for releasably securing a first object to a second objection. The device comprises a casing (12) and a coupling magnet (22) housed in the casing. The casing is configured for being inserted in a passageway formed by aligned openings (54, 60) of the first and second objects when assembled together, for blocking separation of the first object and the second object from one another. The coupling magnet (22) is moveable from an initial position to a working position to form a magnetic coupling for holding the casing in the passageway. The first and second objects can respectively be a tooth (50) of a mining or excavation bucket and an adaptor (52) of the bucket for the tooth (50). A fixed magnet (28) can be provided in the casing (12), the fixed magnet (28) being oppositely poled with respect to the coupling magnet (22) for damping the movement of the coupling magnet to its working position.Type: GrantFiled: June 1, 2020Date of Patent: June 4, 2024Inventor: Perry John Underwood
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Publication number: 20240159258Abstract: There is described a securing device (300) for releasably securing a first object to a second object, the device comprising a casing (12) having a top end (304) and a bottom end (310), and at least one magnet (22) housed within the casing. The casing is configured for being inserted in a passageway formed by aligned openings of the first and second objects when assembled together whereby the casing blocks separation of the first object and the second object from one another. The magnet is automatically movable along the casing (12) to a working position from an initial position within the casing by magnetic attraction to form a magnetic coupling for holding the casing in position when the casing is located in the passageway formed by the aligned openings of the first and second objects.Type: ApplicationFiled: December 2, 2021Publication date: May 16, 2024Inventor: PERRY JOHN UNDERWOOD
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Publication number: 20240141047Abstract: The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: ApplicationFiled: September 27, 2023Publication date: May 2, 2024Inventors: Dhan Sidhartha CHAND, Nicholas Stuart WILSON, Dennis John UNDERWOOD, Benjamin Maxime Morin
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Patent number: 11839653Abstract: Antibodies that specifically bind to TIM 3 and antagonize TIM-3 function pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: GrantFiled: March 2, 2020Date of Patent: December 12, 2023Assignee: AGENUS INC.Inventors: Marc van Dijk, Ekaterina Vladimirovna Breous-Nystrom, Nicholas Stuart Wilson, Jeremy Dale Waight, Dennis John Underwood
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Patent number: 11789277Abstract: A head-mounted display includes a front having a display housing and a back having a rear housing. A first member extends between the front and the back and is adjustable via an actuation of a first rotatable actuator and a first cabling mechanism. A second member extends between the front and the back and is adjustable via an actuation of a second rotatable actuator and a second cabling mechanism. A third member extends between the front and the back and is adjustable via the actuation of the second rotatable actuator and a third cabling mechanism.Type: GrantFiled: December 15, 2021Date of Patent: October 17, 2023Assignee: Valve CorporationInventors: Keaton Snyder, Isaac Frazier, Jos Jacobs, Carl Samuel Conlee, IV, Ivan A. McCracken, Clement Gallois, John Underwood, William Winters, Darryl Jensen
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Patent number: 11638755Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: GrantFiled: December 14, 2020Date of Patent: May 2, 2023Assignees: Agenus Inc., Ludwig Institute for Cancer Research Ltd., Memorial Sloan-Kettering Cancer CenterInventors: Marc van Dijk, Cornelia Anne Mundt, Gerd Ritter, David Schaer, Jedd David Wolchok, Taha Merghoub, Nicholas Stuart Wilson, David Adam Savitsky, Mark Arthur Findeis, Dennis John Underwood, Jean-Marie Cuillerot, Igor Proscurshim, Olga Shebanova
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Publication number: 20230004013Abstract: A head-mounted display (HMD) includes various features that allow for customizing the HMD to different users. The HMD may include an interpupillary distance (IPD) adjustment mechanism that includes a double biasing assembly for smooth, controlled adjustment of the spacing between lens tubes. The HMD may include a field of view (FOV) adjustment mechanism that includes first and second gear assemblies connected via a connecting rod to allow uniform adjustment of the spacing between the lenses and the user's face. The HMD may further include a swappable face gasket, a swappable visor, a removable head strap, and a modular accessory compartment for further customizations to the HMD. The HMD may further include inconspicuous spectrum-transmissive windows that are made with a spectrum-transmissive base material for the HMD housing that is coated with a spectrum-opaque material, and the spectrum-opaque material is selectively removed to create the spectrum-transmissive windows.Type: ApplicationFiled: August 31, 2022Publication date: January 5, 2023Inventors: Ivan A. McCracken, Carl Samuel Conlee IV, Isaac Frazier, Keaton Snyder, John A. Underwood
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Patent number: 11442280Abstract: A head-mounted display (HMD) includes various features that allow for customizing the HMD to different users. The HMD may include an interpupillary distance (IPD) adjustment mechanism that includes a double biasing assembly for smooth, controlled adjustment of the spacing between lens tubes. The HMD may include a field of view (FOV) adjustment mechanism that includes first and second gear assemblies connected via a connecting rod to allow uniform adjustment of the spacing between the lenses and the user's face. The HMD may further include a swappable face gasket, a swappable visor, a removable head strap, and a modular accessory compartment for further customizations to the HMD. The HMD may further include inconspicuous spectrum-transmissive windows that are made with a spectrum-transmissive base material for the HMD housing that is coated with a spectrum-opaque material, and the spectrum-opaque material is selectively removed to create the spectrum-transmissive windows.Type: GrantFiled: April 16, 2020Date of Patent: September 13, 2022Assignee: Valve CorporationInventors: Ivan A. McCracken, Carl Samuel Conlee, IV, Isaac Frazier, Keaton Snyder, John A. Underwood
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Publication number: 20220257733Abstract: Provided are novel antigenic polypeptides comprising tumor-associated peptides, and compositions comprising the same. Such antigenic polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using the polypeptides and compositions, methods of treating a disease using the polypeptides and compositions, kits comprising the polypeptides and compositions, methods of making the compositions, and antibodies and T cell receptors that specifically bind to the polypeptides.Type: ApplicationFiled: January 24, 2022Publication date: August 18, 2022Inventors: Dennis John UNDERWOOD, Paisley Trantham MYERS, Erin Denise JEFFERY, Matthew Joseph PEREZ, Benjamin Maxime MORIN, Mark Arthur FINDEIS, Bishnu JOSHI
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Publication number: 20220235349Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: ApplicationFiled: December 30, 2021Publication date: July 28, 2022Inventors: Yanping Xiao, Nicholas Stuart WILSON, Benjamin Maxime MORIN, Mark Arthur FINDEIS, Cornelia Anne MUNDT, Marc van DIJK, Dhan Sidhartha CHAND, David Adam SAVITSKY, Dennis John UNDERWOOD, Olga IGNATOVICH
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Publication number: 20220220710Abstract: There is described a securing device (10) for releasably securing a first object to a second objection. The device comprises a casing (12) and a coupling magnet (22) housed in the casing. The casing is configured for being inserted in a passageway formed by aligned openings (54, 60) of the first and second objects when assembled together, for blocking separation of the first object and the second object from one another. The coupling magnet (22) is moveable from an initial position to a working position to form a magnetic coupling for holding the casing in the passageway. The first and second objects can respectively be a tooth (50) of a mining or excavation bucket and an adaptor (52) of the bucket for the tooth (50). A fixed magnet (28) can be provided in the casing (12), the fixed magnet (28) being oppositely poled with respect to the coupling magnet (22) for damping the movement of the coupling magnet to its working position.Type: ApplicationFiled: June 1, 2020Publication date: July 14, 2022Inventor: Perry John UNDERWOOD
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Publication number: 20220187609Abstract: A head-mounted display includes a front having a display housing and a back having a rear housing. A first member extends between the front and the back and is adjustable via an actuation of a first rotatable actuator and a first cabling mechanism. A second member extends between the front and the back and is adjustable via an actuation of a second rotatable actuator and a second cabling mechanism. A third member extends between the front and the back and is adjustable via the actuation of the second rotatable actuator and a third cabling mechanism.Type: ApplicationFiled: December 15, 2021Publication date: June 16, 2022Inventors: Keaton Snyder, Isaac Frazier, Jos Jacobs, Carl Samuel Conlee, IV, Ivan A. McCracken, Clement Gallois, John Underwood, William Winters, Darryl Jensen
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Publication number: 20220106581Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: ApplicationFiled: July 19, 2021Publication date: April 7, 2022Applicants: AGENUS INC., AGENUS INC.Inventors: Yanping XIAO, Nicholas Stuart WILSON, Benjamin Maxime MORIN, Mark Arthur FINDEIS, Cornelia Anne MUNDT, Marc van DIJK, Dhan Sidhartha CHAND, David Adam SAVITSKY, Dennis John UNDERWOOD, Olga IGNATOVICH
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Publication number: 20220089732Abstract: The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: ApplicationFiled: April 26, 2021Publication date: March 24, 2022Inventors: Dhan Sidhartha CHAND, Nicholas Stuart WILSON, Dennis John UNDERWOOD, Benjamin Maxime MORIN
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Patent number: 11242385Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.Type: GrantFiled: April 12, 2018Date of Patent: February 8, 2022Assignee: AGENUS INC.Inventors: Yanping Xiao, Nicholas Stuart Wilson, Benjamin Maxime Morin, Mark Arthur Findeis, Cornelia Anne Mundt, Marc van Dijk, Dhan Sidhartha Chand, David Adam Savitsky, Dennis John Underwood, Olga Ignatovich
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Patent number: 11104768Abstract: The present disclosure relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field. The process can include, for example, the steps of: (i) dissolving one or more uncured perfluoropolymer materials in a solvent containing one or more liquid perfluorinated solvent(s) to form a solution; (ii) optionally adding one or more porogens and/or one or more functional additives to the solution formed in (i) to form a mixture; (iii) applying the resultant solution or mixture formed in steps (i) and (ii) to a substrate to form one or more partial or continuous deposited layers on the substrate; (iv) curing the perfluoropolymer within the deposited layer to form a perfluoroelastomeric product; and (v) optionally removing the porogen from the perfluoroelastomeric product.Type: GrantFiled: November 19, 2014Date of Patent: August 31, 2021Assignee: ESP TECHNOLOGY LIMITEDInventors: Christopher John Underwood, Robert Stevens