Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: A technique for measuring distortion in a structure of interest, such as a spacecraft antenna reflector (18), and optionally compensating for the distortion. A first set of targets (22) on the structure (18) is scanned by an attitude transfer system (24) to measure the angular location and range of each target relative to a reference point on another structure (12) having a frame of reference. The orientation of the structure of interest is them determined from the measured locations of the targets. A second set of targets (60 or 82) on the structure of interest is scanned by a figure sensing module (26) located at a reference point on the structure itself. From measured angular locations and ranges of the second set of targets, any shape distortion in the structure of interest can be determined, and distortion may be corrected with the use of actuators (98).