Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Abstract: Anti-theft locking device for securing a wheel medallion having a grease cap well to the wheel of a vehicle. The device is utilized with a conventional wheel medallion of the type having spring retainers that protrude from the body of the medallion and extend into an opening and into a recess in the hub of the wheel. Further, the spring retainers have clips that are configured to pass into the opening and abut the recess of the wheel. A medallion locking cup is provided that is smaller than the medallion well and which is configured to fit therein. The cup has spring retainer openings to allow the clips to flex for mounting and removing the medallion and cup onto the wheel. The cup has an abutting wall portion adjacent the spring retaining opening and the cup is rotated from inside the wheel to lock the medallion and cup onto the wheel with the abutting wall portions abutting the clips.

Abstract: Anti-theft locking device for securing a wheel medallion to the wheel of a vehicle. The device is utilized with a conventional wheel medallion of the type having spring retainers that protrude from the body of the medallion and extend through an opening at the hub of the wheel. Further, the spring retainers have clips that are configured to pass through the opening and abut the surface of the wheel that is opposite to the body of the medallion. A medallion locking disk is provided that is larger than the opening and which will not pass through the opening. The disk has blades which, in the unlocked condition, fit within the confines of the spring retainers and extend between adjacent clips. In the locked condition, the blades are positioned within the clips to hold the clips in an outward position abutting the surface of the wheel. Thus, the clips are prevented from passing through the opening and the medallion is locked to the wheel.