Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.

Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.

Abstract: One embodiment of the present invention provides a system that facilitates instant failover during packet routing by employing a flooding protocol to send packets between a source and a destination. Upon receiving a packet containing data at an intermediate node located between the source and the destination, the system determines whether the packet has been seen before at the intermediate node. If not, the system forwards the packet to neighboring nodes of the intermediate node. In one embodiment of the present invention, forwarding the packet to neighboring needs involves forwarding the packet to all neighboring nodes except the node from which the packet was received. In one embodiment of the present invention, determining whether the packet has been seen before involves examining a sequence number, SR, contained within the packet to determine whether the sequence number has been seen before.

Abstract: Self-tuning objects for developing programs to be executed on parallel computers. A trace file reflecting the sequence of expressions in a user program that include the self-tuning objects is generated during simulation. The trace file is divided into trace file blocks such that data and computational dependencies between trace blocks is minimized. The trace file blocks are converted into source code expression blocks, which are each parameterized to reflect a number of conventional compiler optimization techniques. Various optimization parameter values are applied to the expression blocks to generate minimal timing, compiled versions. The minimal timing compilations of the expression blocks are linked into the user program and executed in response to detection of self-tuning object expressions in the user code. The minimal timing compilations are then mapped to processors within the target parallel computer system for execution.

Abstract: One embodiment of the present invention provides a system that facilitates instant failover during packet routing by employing a flooding protocol to send packets between a source and a destination. Upon receiving a packet containing data at an intermediate node located between the source and the destination, the system determines whether the packet has been seen before at the intermediate node. If not, the system forwards the packet to neighboring nodes of the intermediate node. In one embodiment of the present invention, forwarding the packet to neighboring needs involves forwarding the packet to all neighboring nodes except the node from which the packet was received. In one embodiment of the present invention, determining whether the packet has been seen before involves examining a sequence number, SR, contained within the packet to determine whether the sequence number has been seen before.