Patents by Inventor John Valliere-Douglass

John Valliere-Douglass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10457976
    Abstract: The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug. Whether the oxidizing enzyme survives the purification procedure depends on which purification techniques are employed which can vary from one antibody to another. With knowledge that contamination with a CHO cell oxidizing enzyme is a potential problem for subsequent conjugation, a suitable purification scheme can be devised for any antibody that eliminates or at least reduces CHO oxidizing enzyme(s) to an acceptable level.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 29, 2019
    Assignee: Seattle Genetics, Inc.
    Inventors: Kevin Beam, Damon Meyer, Bradley Hayes, Robert Lyon, John Valliere-Douglass
  • Publication number: 20170159099
    Abstract: The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug. Whether the oxidizing enzyme survives the purification procedure depends on which purification techniques are employed which can vary from one antibody to another. With knowledge that contamination with a CHO cell oxidizing enzyme is a potential problem for subsequent conjugation, a suitable purification scheme can be devised for any antibody that eliminates or at least reduces CHO oxidizing enzyme(s) to an acceptable level.
    Type: Application
    Filed: November 21, 2014
    Publication date: June 8, 2017
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Kevin Beam, Damon Meyer, Bradley Hayes, Robert Lyon, John Valliere-Douglass