Abstract: The present disclosure provides various compounds, compositions, and methods of BACE inhibition that interact with both BACE and APP to increase selectivity of the inhibitor. Compounds presented herein exhibit desirably low IC50 values and permeability across the blood-brain barrier.

Abstract: A method and a system for facilitating multitenancy of services are described herein. The processor 201 of the system may execute instructions stored in memory 203 for generating, fine grained services, wherein fine-grained services comprise code, content and configurations. The processor 201 may orchestrate, fine-grained services in order to form coarse grained services. The processor 201 may receive a request from a user. The processor 201 may identify, the tenant associated with received request from the plurality of tenants. The processor 201 may load, tenant specific content and configuration. The processor 201 may invoke tenant specific flow. The processor 201 may perform dynamic variation on the current code, content and configurations of fine-grained services and coarse-grained services by injecting tenant specific code, content and\or configuration.

Abstract: A method and a system for facilitating multitenancy of services are described herein. The processor 201 of the system may execute instructions stored in memory 203 for generating, fine grained services, wherein fine-grained services comprise code, content and configurations. The processor 201 may orchestrate, fine-grained services in order to form coarse grained services. The processor 201 may receive a request from a user. The processor 201 may identify, the tenant associated with received request from the plurality of tenants. The processor 201 may load, tenant specific content and configuration. The processor 201 may invoke tenant specific flow. The processor 201 may perform dynamic variation on the current code, content and configurations of fine-grained services and coarse-grained services by injecting tenant specific code, content and\or configuration.

Abstract: Concepts and technologies are described herein for a software builder. According to the concepts and technologies disclosed herein, a development platform can execute a software builder. The development system can receive input for creating a mobile application. In response to receiving the input, the development system can create build assets associated with the mobile application. The build assets can include components of the mobile application. The development system also can validate the build assets, store the build assets at a data storage location, compile the assets, and output the mobile application.

Abstract: Concepts and technologies are described herein for a software builder. According to the concepts and technologies disclosed herein, a development platform can execute a software builder. The development system can receive input for creating a mobile application. In response to receiving the input, the development system can create build assets associated with the mobile application. The build assets can include components of the mobile application. The development system also can validate the build as sets, store the build assets at a data storage location, compile the assets, and output the mobile application.

Abstract: Replicas of a database are synchronized. A failure of update data is detected from a first replica to be applied to a second replica. A cause of the failure is determined. The cause of the failure is resolved. The replicas of the database are synchronized without requiring manual intervention.

Abstract: Replicas of a database are synchronized. A failure of update data is detected from a first replica to be applied to a second replica. A cause of the failure is determined. The cause of the failure is resolved. The replicas of the database are synchronized without requiring manual intervention.

Abstract: A system for synchronizing replicas of a database. The system detects a failure of update data from a first replica to be applied to a second replica and determines a cause of the failure. The system also resolves the cause of the failure. According to the system disclosed herein, the present invention synchronizes the replicas of the database without requiring manual intervention.

Abstract: A method for synchronizing replicas of a database. The method includes detecting a failure of update data from a first replica to be applied to a second replica; determining a cause of the failure; and resolving the cause of the failure. According to the method disclosed herein, the present invention synchronizes the replicas of the database without requiring manual intervention.

Abstract: A system for synchronizing replicas of a database. The system detects a failure of update data from a first replica to be applied to a second replica and determines a cause of the failure. The system also resolves the cause of the failure. According to the system disclosed herein, the present invention synchronizes the replicas of the database without requiring manual intervention.

Abstract: A method and system for synchronizing replicas of a database. The method includes detecting a failure of update data from a first replica to be applied to a second replica; determining a cause of the failure; and resolving the cause of the failure. According to the method and system disclosed herein, the present invention synchronizes the replicas of the database without requiring manual intervention.

Abstract: The present invention relates to methods of treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of known compounds of formula (I) wherein R1, R2, R3, U?, U?, V, Y, W, Q, R? are as defined herein.

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.