Patents by Inventor John Varni

John Varni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200255472
    Abstract: Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.
    Type: Application
    Filed: April 28, 2020
    Publication date: August 13, 2020
    Inventors: John VARNI, Stephen LAMBERT, Robert BUSACCA, Russell BURGE
  • Patent number: 10640531
    Abstract: Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: May 5, 2020
    Assignee: UNCHAINED LABS
    Inventors: John Varni, Stephen Lambert, Robert Busacca, Russell Burge
  • Publication number: 20170336311
    Abstract: A measurement apparatus and method for determining a viscosity of a fluid are disclosed. A predetermined pre-fill portion of a sample of the fluid is injected into a capillary at a predetermined flow rate. The pressure differential across the capillary is determined, and the measurement is aborted when the measured pressure is greater than a predetermined maximum pressure. When the measured pressure is less than the predetermined maximum pressure, the remaining portion of the sample is injected into through the capillary. The viscosity of the sample is calculated based on a pressure within the capillary during the injection of the remaining portion of the sample.
    Type: Application
    Filed: August 7, 2017
    Publication date: November 23, 2017
    Inventors: John Varni, Thomas McWaid, Anny Tangkilisan, John Kirkwood, Barry Wong, Stephen Lambert
  • Publication number: 20170096448
    Abstract: Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.
    Type: Application
    Filed: May 21, 2015
    Publication date: April 6, 2017
    Applicant: Unchained Labs
    Inventors: John VARNI, Stephen LAMBERT, Robert BUSACCA, Russell BURGE
  • Publication number: 20070272209
    Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.
    Type: Application
    Filed: August 10, 2007
    Publication date: November 29, 2007
    Applicant: Visyx Technologies, Inc.
    Inventors: Leonid Matsiev, James Bennett, Daniel Pinkas, Mikhail Spitkovsky, Oleg Kolosov, Shenheng Guan, Mark Uhrich, G. Dales, John Varni, Blake Walker, Vladimir Gammer, Dave Padowitz, Eric Low
  • Publication number: 20070077657
    Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.
    Type: Application
    Filed: March 24, 2006
    Publication date: April 5, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Eric Carlson, Peijun Cong, William Chandler, Henry Chau, Earl Danielson, Peter Desrosiers, Robert Doolen, Luping Wu, C. Ramberg, Thomas Crevier, Ralph Nielsen, Colin Masui, John Varni
  • Publication number: 20070052970
    Abstract: An improved method and assembly, wherein the method generally includes the steps of providing a coated or uncoated sensor element having an exposed sensing surface; attaching the sensor element to a platform so that the exposed sensing surface is spaced from the platform; and optionally applying a protective layer over the platform while maintaining the sensing surface as exposed. The assembly includes a resonator having a free portion with a sensing surface is incorporated onto a platform, components of the sensor are physically shielded from harsh operating conditions, the requisite space is maintained between the free portion of the resonator and the platform, and the sensing surface of the resonator remains exposed for sensing.
    Type: Application
    Filed: March 19, 2004
    Publication date: March 8, 2007
    Applicant: Symyx Technologies, Inc.
    Inventors: Oleg Kolosov, Leonid Matsiev, John Varni, G. Dales, Olaf Ludtke, Dirk Wullner, Andreas Buhrdorf, Heiko Dobrinski
  • Publication number: 20060218996
    Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.
    Type: Application
    Filed: May 12, 2006
    Publication date: October 5, 2006
    Applicant: Symyx Technologies, Inc.
    Inventors: Leonid Matsiev, James Bennett, Daniel Pinkas, Mikhail Spitkovsky, Oleg Kolosov, Shenheng Guan, Mark Uhrich, G. Dales, John Varni, Blake Walker, Vladimir Gammer, Dave Padowitz, Eric Low
  • Publication number: 20050211622
    Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.
    Type: Application
    Filed: May 16, 2005
    Publication date: September 29, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: Eric Carlson, Peijun Cong, William Chandler, Peter Desrosiers, J. Freitag, John Varni
  • Publication number: 20050145019
    Abstract: A sensor system and method for analyzing a fluid contained within an environmental control system, comprising the steps of providing a system including a passage for containing a thermal change fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have at least a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.
    Type: Application
    Filed: September 27, 2004
    Publication date: July 7, 2005
    Applicant: Symyx Technologies, Inc.
    Inventors: Leonid Matsiev, Oleg Kolosov, Mark Uhrich, William Rust, John Feland, John Varni, Blake Walker