Patents by Inventor John W. Butcher

John W. Butcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioligand and binding assay
    Patent number: 6838291
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1?-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4?-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 4, 2005
    Assignee: Merck & Co., Inc.
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
    Publication number: 20040209889
    Abstract: Compounds represented by Formula (I): (I)or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
    Type: Application
    Filed: July 29, 2003
    Publication date: October 21, 2004
    Inventors: Christopher F Claiborne, David A Claremon, Brian E Libby, John W Butcher, John A McCauley, Nigel J Liverton, Peter M Munson, Kevin T Nguyen, Brian Phillips, Wayne Thompson
  • N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
    Publication number: 20030119811
    Abstract: Compounds represented by Formula (I): 1
    Type: Application
    Filed: April 2, 2002
    Publication date: June 26, 2003
    Inventors: Nigel J. Liverton, John W. Butcher, Charles McIntyre, Christopher F. Claiborne, David A. Claremon, John A. McCauley, Joseph J. Romano, Wayne Thompson, Peter M. Munson
  • N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
    Publication number: 20020165241
    Abstract: Compounds represented by Formula (I): 1
    Type: Application
    Filed: February 20, 2002
    Publication date: November 7, 2002
    Inventors: Christopher F. Claiborne, John W. Butcher, David A. Claremon, Brian E. Libby, Nigel J. Liverton, Peter M. Munson, Kevin T. Nguyen, Brian Phillips, Wayne Thompson, John A. McCauley
  • Substituted pyridones having cytokine inhibitory activity
    Patent number: 6403596
    Abstract: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: June 11, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, David A. Claremon, John W. Butcher, Cory R. Theberge
  • Radioligand and binding assay
    Publication number: 20020034730
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Application
    Filed: July 12, 2001
    Publication date: March 21, 2002
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • Benzodiazepine derivatives as antiarrhythmic agents
    Patent number: 6214823
    Abstract: This invention is concerned with novel compounds represented by structural formula I which are useful in the treatment of arrhythmia.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: April 10, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, John W. Butcher, David A. Claremon, Harold G. Selnick
  • Substituted imidazoles having cytokine inhibitory activity
    Patent number: 5859041
    Abstract: Compounds represented by formula I: ##STR1## are disclosed. .sup.AR represents an aromatic group containing 6-10 atoms; and ##STR2## represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, David A. Claremon, John W. Butcher, Mark T. Bilodeau
  • Process for the preparation of 1,1-dioxo-7-substituted cephems
    Patent number: 4992541
    Abstract: The present invention relates to an improved process for the preparation of the compounds of formula (I) ##STR1## which involve the direct oxidation without N-protection of the compound of the formula (II) ##STR2##
    Type: Grant
    Filed: August 1, 1989
    Date of Patent: February 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Thomas J. Blacklock, John W. Butcher, Paul Sohar, Theresa Lamanec
  • Automatic telecommunication exchange system
    Patent number: 4233471
    Abstract: A system for centralized reporting of alarm conditions in a multinode data handling system includes an alarm concentration unit at each node of the system for collecting alarm conditions. Each alarm concentration unit is coupled to a signal transmission unit which generates alarm messages and transmits the messages to a centralized node. The centralized node includes means for comparing each received messages with previously received messages stored in a memory and for amending the memory when the most recent received message differs from a previously stored message.
    Type: Grant
    Filed: December 27, 1978
    Date of Patent: November 11, 1980
    Assignee: Standard Telephones and Cables Limited
    Inventors: John A. W. Butcher, Michael A. Salino
  • Synchronization for PCM transmission systems
    Patent number: 4088831
    Abstract: At the transmitter the synchronization information is provided by position modulation of the line transitions of at least one bit of a PCM word. The receiver is synchronized to the received coded signal by detecting the position modulation of the bit of the PCM word. This arrangement avoids the need for extra bits to convey synchronization information.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: May 9, 1978
    Assignee: International Standard Electric Corporation
    Inventors: John A. W. Butcher, Edward H. Lambourn