Patents by Inventor John W. Hanna

John W. Hanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for enhancing proteasome activity
    Patent number: 9201073
    Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: December 1, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee
  • Methods and Compositions for Enhancing Proteasome Activity
    Publication number: 20140199706
    Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 17, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee
  • Clip-on compass
    Patent number: 4404752
    Abstract: The invention is in the field of compass course following and comprises a means and method of mounting a compass directly on a map with a North-South reference line and following a course on the map directly once the compass needle is aligned with North. In all references to the direction "North" throughout this document magnetic North only shall apply.
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: September 20, 1983
    Inventor: John W. Hanna
  • Lake pump suction mechanism
    Patent number: 4152264
    Abstract: A suction mechanism submerged underwater in a lake, the suction mechanism being designed to eliminate sand and mud from entering a foot valve connected to hoses for pumping water out of lake for use; the suction mechanism including the foot valve being at the upper end of a vertical suction pipe, the foot valve being covered by a protective dome, a horizontal anchor stand supporting the suction pipe vertically and the lines leading from the lake including a suction pipe and a pressure pipe.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: May 1, 1979
    Inventor: John W. Hanna, Sr.