Patents by Inventor John W. Lough

John W. Lough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preventing or treating cardiac hypertrophy
    Patent number: 7838561
    Abstract: A method for treating or preventing cardiac hypertrophy in a mammal, comprising manipulating levels of RBP, retinoids, or an affiliated signaling and regulatory pathway in the mammal. Preferably, the method comprises reducing or inhibiting the level of RBP or retinoids or their signaling pathway, or an affiliated signaling pathway, via a dietary, genetic, protein-based, or pharmacologic approach, or a combination thereof. Also disclosed are pharmaceutical composition suitable for the method.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: November 23, 2010
    Assignees: Wisconsin Alumni Research Foundation, MCW Research Foundation, Inc.
    Inventors: Susan M. Smith, John W. Lough, George R. Flentke
  • Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
    Publication number: 20020061837
    Abstract: A composition comprising a purified mixture of a bone morphogenetic protein and a fibroblast growth factor is disclosed. In another embodiment, the present invention is a method of inducing cardiogenesis in cells of a non-cardiac lineage comprising the steps of exposing cells to the composition and observing the development of cardiac cells.
    Type: Application
    Filed: May 8, 2001
    Publication date: May 23, 2002
    Inventors: John W. Lough, Matthew R. Barron
  • BONE MORPHOGENETIC PROTEIN AND FIBROBLAST GROWTH FACTOR COMPOSITIONS AND METHODS FOR THE INDUCTION OF CARDIOGENESIS
    Publication number: 20010007023
    Abstract: A cardiogenic composition comprising a purified mixture of a transforming growth factor-&bgr; protein and a fibroblast growth factor is disclosed. In another embodiment, the present invention is a method of inducing cardiogenesis in cells of a non-cardiac lineage comprising the steps of exposing cells to the composition and observing the development of cardiac cells.
    Type: Application
    Filed: April 7, 1998
    Publication date: July 5, 2001
    Inventors: JOHN W. LOUGH JR., MATTHEW R. BARRON, MICHAEL A. BROGLEY, XIAOLEI ZHU, JOHN E. BAKER