Patents by Inventor John W. Lyle

John W. Lyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8047915
    Abstract: A video game character or avatar is generated using images of the player so that the on-screen avatar being controlled by the player appears like the player. Answers to a questionnaire or a psychological profile are provided by the player to determine characteristics that the player views as desirable, which are used to generate a final version of the avatar. Iterations of the avatar appearance are generated from the initial appearance to the final, more desirable appearance. Using the avatar, as play of the game proceeds the player's avatar begins as a character appearing like themselves and gradually becomes a character that is more as they would like to appear. The avatar increases the emotional impact of games by providing strong visual and psychological connections with the player. The avatar may instead begin from an initial character that does not appear similar to the player. The iterations may make the avatar gradually less appealing or with other changes in appearance, in some embodiments.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: November 1, 2011
    Assignee: Lyle Corporate Development, Inc.
    Inventors: John W. Lyle, Brenton Lyle, Robert S. Ellsworth
  • Publication number: 20090124584
    Abstract: Methods and formulations for the regeneration of vaginal tissue and vaginal cell health resulting from vaginal cell hypoxia in a human female. A pharmaceutical composition for topical non-systemic administration is formulated containing a hormonal agent administered to the vagina, vulvar area of the individual undergoing treatment.
    Type: Application
    Filed: January 20, 2006
    Publication date: May 14, 2009
    Applicant: LYLE CORPORATE DEVELOPMENT, INC.
    Inventor: John W. Lyle
  • Patent number: 6406716
    Abstract: The effectiveness of an anticonvulsant such as gabapentin for alleviating neuropathic pain is potentiated by a nontoxic antagonist for the N-methyl-D-aspartate receptor or nontoxic substance that blocks a major intracellular consequence of N-methyl-D-aspartate receptor activation.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: June 18, 2002
    Assignee: Endo Pharmaceuticals Inc.
    Inventors: Frank S. Caruso, Fredrick L. Minn, John W. Lyle
  • Publication number: 20010008889
    Abstract: The analgesic effectiveness of an tramadol is significantly enhanced by administering tramadol prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.
    Type: Application
    Filed: February 9, 2001
    Publication date: July 19, 2001
    Inventors: Frank S. Caruso, Fredrick L. Minn, John W. Lyle
  • Patent number: 6187338
    Abstract: The analgesic effectiveness of tramadol is significantly enhanced by administering tramadol prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: February 13, 2001
    Assignee: Algos Pharmaceutical Corporation
    Inventors: Frank S. Caruso, Fredrick L. Minn, John W. Lyle
  • Patent number: 5891463
    Abstract: A nonocclusive drug delivery device includes (a) an open cell, flexible, oleophilic thermoplastic resin foam layer, (b) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic barrier layer bonded to the upper surface of the foam layer, (c) a pressure sensitive adhesive layer and (d) a drug composition comprising a drug and an oleophilic drug delivery vehicle.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: April 6, 1999
    Assignee: U.S. Dermatologics, Inc.
    Inventors: Gastone P. Bello, John W. Lyle, Donald A. Johnson
  • Patent number: 5869498
    Abstract: The analgesic effectiveness of a combination drug containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: February 9, 1999
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5863922
    Abstract: The analgesic effectiveness of a combination drug containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: January 26, 1999
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5840731
    Abstract: The analgesic effectiveness of a combination drug composition containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: November 24, 1998
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5834479
    Abstract: The analgesic effectiveness of an NSAID is significantly enhanced by administering the NSAID prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: November 10, 1998
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5716621
    Abstract: A nonocclusive drug delivery device includes (a) an open cell, flexible, oleophilic thermoplastic resin foam layer, (b) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic barrier layer bonded to the upper surface of the foam layer, (c) a pressure sensitive adhesive layer and (d) a drug composition comprising a drug and an oleophilic drug delivery vehicle.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: February 10, 1998
    Assignee: PharmaDyn, Inc.
    Inventors: Gastone P. Bello, John W. Lyle, Donald A. Johnson
  • Patent number: 5654281
    Abstract: Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl) -5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: August 5, 1997
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5571079
    Abstract: A wound dressing possessing a wound exudate-absorbing component and at least one liquid-impermeable dressing-securing component is manufactured from the same flexible, cellular, thermoplastic resin workpiece.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 5, 1996
    Assignee: Algos Pharmaceutical Corporation
    Inventors: Gastone P. Bello, John W. Lyle, Donald A. Johnson
  • Patent number: 5556838
    Abstract: Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: September 17, 1996
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5505958
    Abstract: A transdermal drug delivery device possessing a drug-storing matrix and at least one drug delivery device-securing component is manufactured from the same flexible cellular thermoplastic resin workpiece.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 9, 1996
    Assignee: Algos Pharmaceutical Corporation
    Inventors: Gastone P. Bello, John W. Lyle, Donald A. Johnson
  • Patent number: 5502058
    Abstract: A method of alleviating pain such as neuropathic pain or acute inflammatory pain is provided which comprises administering to a mammal that is either exhibiting pain or is about to be subjected to a pain-causing event a pain alleviating/pain suppressing amount of at least one nontoxic antagonist for the N-methyl-D-aspartate receptor, e.g., dextrorphan, or metabolic precursor of such antagonist, e.g., dextromethorphan, or at least one nontoxic substance that blocks a major intracellular consequence of N-methyl-D-aspartate receptor activation, e.g., a phenothiazine such as trifluoperazine.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: March 26, 1996
    Assignee: Virginia Commonwealth University
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5352683
    Abstract: Chronic pain is alleviated in a mammal suffering therefrom by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, alone or in combination with a local anesthetic and optionally in sustained release dosage form.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: October 4, 1994
    Assignee: Virginia Commonwealth University Medical College of Virginia
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5321012
    Abstract: Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
    Type: Grant
    Filed: April 6, 1993
    Date of Patent: June 14, 1994
    Assignee: Virginia Commonwealth University Medical College
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Patent number: 5061286
    Abstract: At least a portion of the surface of an osteoprosthetic implant is provided with demineralized bone powder adhering thereto. Sorption of the bone particles is accompanied by rapid and deep bone in-growth which firmly anchors the prosthesis to the host bone repair site.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: October 29, 1991
    Assignee: Osteotech, Inc.
    Inventor: John W. Lyle
  • Patent number: 4863473
    Abstract: A prosthesis for replacing bone extracted from a cadaver. A preferred prosthesis is formed of two tubes of differing diameter, the larger-diameter tube beng slidable over the smaller-diameter tube to provide a telescoping assembly. A stop is provided on the smaller tube, and is adjustably positioned thereon for operatively contacting an end of the larger tube to resist contraction of the assembly after insertion within a cadaver. Threaded pins are provided at the ends of the assembly for engagement within bone of a skeleton of the cadaver. The prosthesis retains the physical appearance of a cadaver after extraction of bone for use in surgical and other therapeutic purposes on living organisms.
    Type: Grant
    Filed: April 6, 1988
    Date of Patent: September 5, 1989
    Assignee: Osteotech, Inc.
    Inventors: Frank P. Glowczewskie, Jr., Alfred A. Litwak, Jamie M. Grooms, John W. Lyle