Abstract: Devices, systems, and methods are provided for mitral repair of a mitral valve within a heart of a subject that includes introducing a distal portion of a delivery device carrying an artificial chordae into the vasculature of the subject; advancing the distal portion into a right atrium of the heart and trans-septally from the right atrium into a left atrium of the heart; directing the distal portion through a mitral valve of the heart into a left ventricle of the heart; securing a distal end of the artificial chordae to a posterior ventricular wall of the heart adjacent the mitral valve; coupling a leaflet anchor end of the artificial chordae to a posterior leaflet of the mitral valve; adjusting a distance between the leaflet anchor and the distal end of the artificial chordae until coaptation of the mitral valve is improved and/or regurgitation is eliminated; and removing the delivery device from the subject's body.