Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK?) and diacylglycerol kinase zeta (DGK?), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

Abstract: A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: This invention discloses a method of improving the die casting process by the application of the inventor's mathematics and physics stored in a computer to control the injection speed and the timing of the excitation of an intensifier. Using either data from a die surface temperature for a selected location detected by a pyrometer, the last instant before the die is closed, or the alloy-die interface boundary data from a thermocouple, the inventor's equations loaded in a computer calculate and graph the solidification pattern for the casting wall and the quantity of heat remaining in the alloy wall vs. time above the dynamic solidus thereby establishing parameters for control of facets of the injection phase. The unique properties of the boundary's transient temperature during solidification have been shown by the inventor's mathematics to be of vital import to the determination of the solidification pattern used to control injection.

Abstract: This invention discloses a method of improving the die casting process by the application of the inventor's mathematics and physics stored in a computer to control the injection speed and the timing of the excitation of an intensifier. Using either data from a die surface temperature for a selected location detected by a pyrometer, the last instant before the die is closed, or the alloy-die interface boundary data from a thermocouple, the inventor's equations loaded in a computer calculate and graph the solidification pattern for the casting wall and the quantity of heat remaining in the alloy wall vs. time above the dynamic solidus thereby establishing parameters for control of facets of the injection phase. The unique properties of the boundary's transient temperature during solidification have been shown by the inventor's mathematics to be of vital import to the determination of the solidification pattern used to control injection.

Abstract: A low-profile faceplate assembly for a two-piece ostomy appliance, and a method for manufacturing it, are disclosed. The faceplate includes a wafer of an adhesive skin barrier material and a flexible plastic coupling ring (for detachably coupling the faceplate to an ostomy pouch having a mating ring), and is distinguished by the mounting flange of the coupling ring being embedded within the faceplate.

Abstract: A faceplate for an ostomy appliance is disclosed in which a unitary release sheet covers both the bodyside (rear) surface of an adhesive skin barrier layer and the surrounding adhesive surface of an outwardly-projecting porous covering layer. The barrier layer is beveled to a feathered outer edge and the release sheet contacts the adhesive surface of the covering layer immediately adjacent the outer edge of said barrier layer. A continuous in-line method for making such faceplates is disclosed.

Abstract: A low-profile faceplate assembly for a two-piece ostomy appliance, and a method for manufacturing it, are disclosed. The faceplate includes a wafer of an adhesive skin barrier material and a flexible plastic coupling ring (for detachably coupling the faceplate to an ostomy pouch having a mating ring), and is distinguished by the mounting flange of the coupling ring being embedded within the faceplate. The faceplate is made by a convergence of in-line processes taking place simultaneously with an injection/compression molding operation for the skin barrier wafer as disclosed in U.S. Pat. No. 5,716,475, thereby eliminating or greatly reducing the assembly labor for the various process steps plus the handling, storing and transferring steps commonly associated with the manufacture of ostomy faceplate assemblies.

Abstract: A die member in an ejector die assembly is movable obliquely with respect to the axis of movement of the ejector die assembly. Backup plate means is connected to the ejector die assembly by a lost motion connection. The backup plate means locks the die member by direct engagement with the die member in the machine closed position and is moved away from the ejector die assembly in the machine open position to permit withdrawal of the die member from the die cavity.

Abstract: Production of a solution of a chloroprene polymer, suitable for use as a component for an adhesive, by dissolving the polymer in a solvent, and heating the solution, adding a free-radical catalyst and contacting the solution with a molecular oxygen containing gas, until the viscosity of the solution is lowered by at least about 10%.