Patents by Inventor John W. McLean

John W. McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100226970
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Application
    Filed: February 10, 2010
    Publication date: September 9, 2010
    Inventors: Donald M. McDonald, John W. McLean, O. Gavin Thurston
  • Patent number: 7688348
    Abstract: The system and method relate to detection of objects that are submerged, or partially submerged (e.g. floating), relative to a water surface. One aspect of the invention emits LIDAR fan-beam pulses and analyzes return-pulse portions to determine water-surface orientations and derive submerged-object images corrected for refractive distortion. Another defines simulated images of submerged objects as seen through waves in a water surface, prepares an algorithm for applying a three-dimensional image of the water surface in refractive correction of LIDAR imaging through waves—and also models application of the algorithm to the images, and finally specifies the LIDAR-system optics. Yet another emits nearly horizontal pulses to illuminate small exposed objects at tens of kilometers, detects reflected portions and images successive such portions with a streak-tube subsystem. Still others make special provisions for airborne objects.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: March 30, 2010
    Assignee: Arete' Associates
    Inventors: Stephen C. Lubard, John W. McLean, David N. Sitter, Jr., J. Kent Bowker, Anthony D. Gleckler
  • Patent number: 7683928
    Abstract: The system and method relate to detection of objects that are submerged, or partially submerged (e.g. floating), relative to a water surface. One aspect of the invention emits LIDAR fan-beam pulses and analyzes return-pulse portions to determine water-surface orientations and derive submerged-object images corrected for refractive distortion. Another defines simulated images of submerged objects as seen through waves in a water surface, prepares an algorithm for applying a three-dimensional image of the water surface in refractive correction of LIDAR imaging through waves—and also models application of the algorithm to the images, and finally specifies the LIDAR-system optics. Yet another emits nearly horizontal pulses to illuminate small exposed objects at tens of kilometers, detects reflected portions and images successive such portions with a streak-tube subsystem. Still others make special provisions for airborne objects.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: March 23, 2010
    Assignee: Arete' Associates
    Inventors: Stephen C. Lubard, John W. McLean, David N. Sitter, Jr., J. Kent Bowker, Anthony D. Gleckler
  • Publication number: 20100002222
    Abstract: The system and method relate to detection of objects that are submerged, or partially submerged (e.g. floating), relative to a water surface. One aspect of the invention emits LIDAR fan-beam pulses and analyzes return-pulse portions to determine water-surface orientations and derive submerged-object images corrected for refractive distortion. Another defines simulated images of submerged objects as seen through waves in a water surface, prepares an algorithm for applying a three-dimensional image of the water surface in refractive correction of LIDAR imaging through waves—and also models application of the algorithm to the images, and finally specifies the LIDAR-system optics. Yet another emits nearly horizontal pulses to illuminate small exposed objects at tens of kilometers, detects reflected portions and images successive such portions with a streak-tube subsystem. Still others make special provisions for airborne objects.
    Type: Application
    Filed: December 27, 2004
    Publication date: January 7, 2010
    Applicant: Arete Associates
    Inventors: Stephen C. Lubard, John W. McLean, David N. Sitter, JR., J. Kent Bowker, Anthony D. Gleckler
  • Patent number: 7238369
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Donald M. McDonald, John W. McLean, O. Gavin Thurston
  • Patent number: 7112338
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: September 26, 2006
    Assignee: The Regents of the University of California
    Inventors: Donald M. McDonald, John W. McLean, O. Gavin Thurston
  • Patent number: 6873716
    Abstract: The system images the volume of a turbid medium and detects the contents. The medium can be water or air, or living tissue, or almost any other material which is at least partially light-transmissive. The system includes a light source for producing a series of discrete fan-shaped pulse beams that are substantially uniform in intensity or have been peaked at the edges of the fan to illuminate sections of the medium, a streak tube with a large, thin-slit-shaped photocathode for collecting the maximum amount of light from weak returns, a field-limiting slit disposed in front of the cathode for removing multiply scattered light, a large-aperture optical element for collecting and focusing the reflected portions of the pulse beam on the field-limiting slit and the cathode, and an array of detectors.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: March 29, 2005
    Assignee: Areté Associates
    Inventors: J. Kent Bowker, Stephen C. Lubard, John W. McLean
  • Patent number: 6836285
    Abstract: In some aspects of the invention, a LIDAR subsystem or other means at an elevated position emit thin fan-beam light pulses at a shallow angle, and detect reflected portions of the pulses at a like angle; a streak-tube subsystem or other means image successive reflected portions to detect objects, for example near a water craft if the elevated position is on such a craft (e.g., a mast or high bridge). In some aspects, the imaging means perform the imaging in a way that tightly localizes reflection from a water surface near the objects, to facilitate detecting the objects despite proximity to the surface. Some preferred embodiments apply a correction for energy reduction, or depth errors, near lateral ends of the fan beam; a lenslet array is preferred for applying the correction. Preferably the shallow angle is in a range of approximately one to fifteen degrees, more preferably approximately two to ten degrees, ideally roughly five degrees.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: December 28, 2004
    Assignee: Arete Associates
    Inventors: Stephen C. Lubard, John W. McLean, David N. Sitter, Jr., J. Kent Bowker, Anthony D. Gleckler
  • Publication number: 20020168355
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Application
    Filed: May 28, 2002
    Publication date: November 14, 2002
    Inventors: Donald M. McDonald, John W. McLean, O. Gavin Thurston
  • Patent number: 5837486
    Abstract: Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: November 17, 1998
    Assignee: Genentech, Inc.
    Inventors: Sarah C. Bodary, Cornelia M. Gorman, John W. McLean, Mary A. Napier
  • Patent number: 5726290
    Abstract: Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: March 10, 1998
    Assignee: Genentech, Inc.
    Inventors: Sarah C. Bodary, Cornelia M. Gorman, John W. McLean, Mary A. Napier
  • Patent number: 5726037
    Abstract: Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: March 10, 1998
    Assignee: Genentech, Inc.
    Inventors: Sarah C. Bodary, Cornelia M. Gorman, John W. McLean, Mary A. Napier
  • Patent number: 5635601
    Abstract: The cDNA encoding a novel beta integrin subunit, called the beta-8 integrin subunit, has been isolated from rabbit and human tissue and sequenced. Provided herein is nucleic acid sequence of the beta-8 integrin subunit useful as a diagnostic and in the recombinant preparation of beta-8 integrin subunit and alpha-beta integrin complexes. The beta-8 integrin subunit is used in the preparation and purification of antibodies thereto, and in diagnostic assays.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 3, 1997
    Assignee: Genentech, Inc.
    Inventors: Matthew Moyle, John W. McLean
  • Patent number: 5250585
    Abstract: A dental material in powder form and being based on(a) aluminum fluorosilicate glass,(b) base metals suitable for dental use, or alloys of these with each other, and optionally(c) dry polycarboxylic acid and/or(d) a chelating agent,which contains at least some of constituent (a) as a sintered mixture with constituent (b).
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: October 5, 1993
    Assignee: ESPE Stiftung & Co. Produktions- und Vertriebs KG
    Inventors: Rainer Guggenberger, Klaus Ellrich, Oswald Gasser, John W. McLean, Owen Makinson
  • Patent number: 5049488
    Abstract: Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: September 17, 1991
    Assignee: Genentech, Inc.
    Inventors: Bradford W. Baer, Dennis T. Drayna, Richard M. Lawn, John W. McLean
  • Patent number: 4527979
    Abstract: Powdered dental material of a sintered mixture of calcium aluminum fluorosilicate glass and precious metals (or alloys thereof with each other or with up to 40% non-precious metals), which may optionally contain polycarboxylic acid and/or a chelating agent and/or further powdered precious metal. The dental material can be prepared by sintering a mixture of the glass and the precious metal at a temperature greater than 600.degree. C., grinding the sintered product to a powder and admixing the optional further components. Use of the self-hardening glass ionomer cements for dental filling purposes gives fillings having excellent resistance to wear, most notably at the edges and corners in the molar region.
    Type: Grant
    Filed: December 21, 1983
    Date of Patent: July 9, 1985
    Assignee: ESPE, Fabrik pharmazeutischer Praparate GmbH
    Inventors: John W. McLean, Oswald Gasser