Abstract: A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.

Abstract: A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.

Abstract: A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.

Abstract: A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.

Abstract: The present invention relates to methods of using nucleotide sequences from the promoter region of a S. cerevisiae gene YRM325W whose expression is an indicator of inhibition or modulation of the sterol biosynthesis pathway in S. cerevisiae. The invention envisions using a target polynucleotide sequence, wherein the target polynucleotide sequence is operably linked to the promoter region of the YMR325W gene, to screen chemical libraries and natural products for compounds which can be used either as antifungal agents for use against a variety of fungal pathogens, or as lipid lowering agents to treat hypercholesterolemia. The invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents and lipid lowering agents, and/or to monitor the activity of the sterol biosynthesis pathway.

Abstract: The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or “regulon”. These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest (“regulon target genes”) The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.

Abstract: The present invention relates to methods of using nucleotide sequences from the promoter region of at least one of seven S. cerevisiae genes whose expression is an indicator of the inhibition or modulation of the glucan synthase pathway in S. cerevisiae. This invention envisions using at least one target polynucleotide sequence, each target polynucleotide sequence being operably linked to the promoter region of one of the seven glucan synthase pathway reporter genes, to screen chemical libraries and natural products for compounds which can be used as antifungal agents for use against a variety of fungal pathogens. This invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents, and/or to monitor the activity of the glucan synthase pathway.

Abstract: A method for distinguishing an ordinary binary floating point number from an extraordinary binary floating point number is provided, the method including adding 1 to a B-bit biased exponent of a binary floating point number to produce a (B+1)-bit augmented exponent and sign-extending the augmented exponent to produce a (B+n)-bit transformed exponent. The method also includes testing the (B+n)-bit transformed exponent to determine if the (B+n)-bit transformed exponent is less than 2.

Abstract: The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or “regulon”. These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest (“regulon target genes”) The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.

Abstract: A fin (1) suitable for stabilizing the flight of a projectile for example, is formed with an integral cantilever spring member (4). The fin (1) is rotatable about a pivot (3) from an initial stowed position (not shown) to a deployed position. The spring (4) is initially retained against the fin (1) but when it is released, the fin is forced outwards to its deployed position by the action of the spring (4), the free end of the spring moving into engagement with a surface (7) to retain the fin in the deployed position.

Abstract: A simulated leather checkbook cover includes an outer cover sheet and an inner pocket-forming sheet of vinyl sheet material. The peripheral edge of the outer sheet is turned inwardly over and around the peripheral edge of the inner sheet, and the layers of the edge portion are secured to each other by a radio-frequency dielectric heat sealed vinyl-to-vinyl bond and by a line of threaded stitching extending through all three layers close to the turned over edge. The cover sheet has a flow-molded design portion in its outer surface with a depth and pattern simulating a hand-tooled leather design. The design portion includes a depressed flat area within which any selected one of a plurality of originally separate and differently ornamental inserts is adhesively secured.