Abstract: A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins. Also disclosed are antisense agents able to decrease or prevent translation of a human HP4 prostaglandin receptor.

Abstract: The present invention provides mehtods for screening for substances which inhibit the interaction between a FP prostanoid receptor and a compoudn having PGF2&agr;alphaactivity, methods for inhibiting the interaction, methods of inhibiting signaling mediated by &bgr;beta-catenin, and methods of treating cancer.

Abstract: A gene encoding the human EP3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3′ untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.

Abstract: A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins. Also disclosed are antisense agents able to decrease or prevent translation of a human HP4 prostaglandin receptor.

Abstract: A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins. Also disclosed are antisense agents able to decrease or prevent translation of a human HP4 prostaglandin receptor.

Abstract: A gene encoding the human EP3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3′ untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.

Abstract: A gene encoding the human EP.sub.3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP.sub.3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3' untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.

Abstract: A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins.

Abstract: A method of controlling the reheat steam temperature in a circulating fluidized bed combustion system wherein the circulating solids are cooled in a heat recovery fluid bed system containing reheat heat exchange surface. The rate of heat transfer and thus the reheat steam temperature are controlled by adjusting the flow rate of fluidizing air to the portion of the heat recovery fluid bed system containing the reheat surface.

Abstract: In a pulverized fuel-fired steam generator, a steam air heater is disposed in the air inlet duct to the main air heater. Steam from an auxiliary in-plant source or from the boiler itself is passed through the steam air heater thereby increasing the temperature of the air entering the main air heater. The flow rate of steam passed through the steam air heater is regulated to maintain the flue gas temperature entering dust collection equipment located in the flue gas stream downstream of the main air heater above the dew point of water vapor and the condensation point of sulfuric acid during start-up and low load operations.