Abstract: A system and method operative in accordance with the present disclosure facilitate storage and retrieval of individual or discrete samples of biological, non-biological, and chemical material stored on dry media. Sample material may be disposed upon or within a porous or solid (i.e., non-porous) sample storage medium and subsequently archived in, and retrieved from, storage elements such as multi-well plates, for example, using robotic devices or other automated apparatus. The disclosed system and method enable ejection of sample material from a sealed storage element into a specific well of a multi-well daughter plate, or into a specific cuvette, test tube, or similar container. In some embodiments, a sample carrier comprising a storage medium may be punched or ejected through a first seal of the storage element with an apparatus or implement such as a disposable piercing tip, for instance, inserted through a second seal of the storage element.

Abstract: Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

Abstract: Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

Abstract: Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.

Abstract: An inner control loop controls the relative position of a surface to be scanned with respect to a focal plane. An outer control loop responds to the location of the surface to be scanned with respect to a focal plane of the scan lens to generate a setpoint for the inner control loop. A sample-and-hold element disposed between the inner and outer control loops is switched by an edge or defect detector. It is preferred that the outer control loop has a time constant in the range of three to ten times longer than that of the inner control loop. The sample-and-hold element provides a gradual state transition upon the occurrence of an edge or a surface defect.

Abstract: Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

Abstract: Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

Abstract: Apparatus and method for scanning a surface. An optical system generates a light beam to illuminate a surface. A carrier supports the surface for reciprocating motion with respect to the light beam to form one axis of a raster. A propulsion system moves the carrier at a substantially constant speed and a position sensor provides an output signal representing the surface position with respect to the light beam. A control system responsive to the output signal modulates a sample period reciprocally to carrier speed to achieve substantially constant scan length per sample and to control data acquisition timing.

Abstract: A method and apparatus for producing a set of compensated commands for a spot position mechanism. A dimensioned grating is placed across the beam path and an image of the grating is generated. The image is analyzed and the pixel position of the grating edges is compiled. From this a list of grating edge distances is produced and used to generate observed edge positions. A line is fit and removed from the list to produce a list of observed errors. The observed errors are correlated to the proper position space and a set of positions errors is produced. The position errors are subtracted from the command positions to produce a set of correction positions. This set of corrected positions can be used to command the spot position mechanism. The positions might also be tabulated and referenced. Interpolation between the points can also be performed.

Abstract: A technique for analyzing analytes in a chemical array having a plurality of pixels is provided. The apparatus of the technique contains a light source for irradiating a light beam at the pixels individually, a controller for controlling the relative position of the light source to the array, and a detector for detecting fluorescence resulting from irradiation. The controller controls the light beam generated by the light source to irradiate a first number of pixels sequentially in the array and repeating one or more times the sequential irradiation before irradiating a second number of pixels, the pixels of which are different from those of the first number of pixels. The first number of pixels includes more than one pixel but less than the total number of pixels in the array.

Abstract: A technique for analyzing analytes in a chemical array having a plurality of pixels is provided. The apparatus of the technique contains a light source for irradiating a light beam at the pixels individually, a controller for controlling the relative position of the light source to the array, and a detector for detecting fluorescence resulting from irradiation. The controller controls the light beam generated by the light source to irradiate a first number of pixels sequentially in the array and repeating one or more times the sequential irradiation before irradiating a second number of pixels, the pixels of which are different from those of the first number of pixels. The first number of pixels includes more than one pixel but less than the total number of pixels in the array.

Abstract: A method and system of operating a laser device includes utilizing an integral power-regulation sensor of the laser device to detect energy back reflected from an object of interest and then using the detected signal as a basis for determining a characteristic related to the object of interest. In the preferred embodiment, the determined characteristic is the position of the beam focus relative to a surface of the object. Also in the preferred embodiment, the integral power-regulation sensor is disconnected from power-regulation circuitry during the focusing operation. Interaction of the back reflected energy and the outgoing beam can be reduced by introducing beam rotation, such as by providing a quarter-wave plate along the beam path. Focusing sensitivity can be increased by locating reflective targets over the surface and by executing AC measurements to filter DC components from the signal.

Abstract: A football game apparatus comprising a game board having a model football field thereon and a playing piece movable therealong, an offensive play board having offensive player selected columns corresponding to offensive plays and chance selected rows intersecting with the columns to define offensive blocks, each containing yardage values, and a defensive play board having defensive player selected columns corresponding to defensive plays and chance selected rows intersecting with the columns to define defensive blocks, each containing yardage values, wherein the values obtained in the selected offensive and defensive blocks are compared to determine the net yardage of each play and the corresponding movement of the playing piece. Substitute offensive and defensive columns are provided to vary the offensive and defensive yardage values. Certain offensive and defensive blocks contain turn-over indicia which, when matched, result in the turn-over of possession of the playing piece between players.