Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: In a door closer comprising spring means (17) within a housing (10) adapted for mounting with the thickness of the door (12) and an anchor member (30) adapted for mounting on a door frame (32), a tension member (20) whereby the spring means draws the anchor member towards the housing to effect door closure includes at least an outer end portion in the form of a cable (21) at its free end a domed abutment member (22) which is engaged behind the anchor member (30) and at a position spaced from the abutment member a collar (25) of non-round external shape whereby firstly a spacer member (40) can be interposed between the collar (25) and the housing (10) to facilitate the mounting of the closer, and secondly by engagement of the collar (25) by means of a spanner (50) the capable can be rotated to adjust the spring force of the closer through axial movement of a member (18) which is acted on by the spring ( 15) relative to a threaded member (19) at the inner end of the tension member (20).