Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.

Abstract: Described herein are systems and methods for reducing the size of data payloads delivered to downstream processing from a raw series of biological sensor recordings. In one variation, the system comprises a low-power hardware architecture that combines serially sampled neural signal data with a transformation matrix (TFM) using a novel systolic random-logic-macro (RLM) array.

Abstract: Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

Abstract: Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.

Abstract: A device includes a lock detect circuit that is structured and arranged to: convert a reference clock to a reference triangle wave; convert a feedback clock to a feedback triangle wave; determine whether the feedback triangle wave is within a tolerance margin that is defined relative to the reference triangle wave; and generate a determiner output that is a first value when the feedback triangle wave is not within the tolerance margin, and a second value when the feedback triangle wave is within the tolerance margin.