Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (a.a.119 to 133) have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.

Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.

Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.

Abstract: An enclosure includes a hollow robe disposed at a first end thereof and extending outwardly there-from. A collapsible bulb is attached to a second end of the enclosure for drawing atmosphere into the enclosure through the hollow robe when the bulb is squeezed and released. The enclosure further includes a viewing aperture. An indicating strip is disposed in the enclosure such that the strip is in environmental communication with the interior of the enclosure and viewable through the viewing aperture from outside of the enclosure. The indicating strip is configured to change in appearance when gases indicating the presence of food contamination are absorbed by the strip.

Abstract: A gum dispenser includes a substantially rectangular, box shaped container having a platform therein. The platform is disposed substantially parallel to a first wall and a second wall of the container. When sticks of gum are positioned between the platform and the second wall of the container, a spring urges the platform against the sticks of gum, and a leading stick of gum is urged against the second wall of the container. The second wall of the container includes a track, with an operator slidably engaged therein. When a user slides the operator toward a slot in the lid of the dispenser, a seat of the operator engages a short edge of the leading stick of gum and pushes the gum partially through the slot, thereby dispensing the gum. The container further includes a base with a notch therein for limiting movement of the operator in a direction away from the lid, so that the operator remains engaged within the track.

Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.

Abstract: An eccentricity gauge and orifice plate combination which is used to determine the position of an orifice plate located in an orifice fitting serving a pipeline. In a most preferred embodiment the orifice plate is designed to replace the conventional orifice plate in a conventional orifice fitting and is provided with a hub for lengthening the orifice flow opening to accommodate and stabilize the eccentricity gauge. In a first embodiment the eccentricity gauge includes a dowel pin for insertion in the orifice flow opening, a mount which receives the dowel pin, a dial indicator device adjustably carried by the mount and having a spring-loaded contact point positioned for contact with the inside bore wall of the orifice fitting to measure the eccentricity of the contact point path as the eccentricity gauge is rotated about the orifice flow opening.

Abstract: A novel athletic shoe is disclosed which has a midsole in which is provided a resilient member having parallel grooves which in cross-section have a triangular profile.

Abstract: Tool support apparatus having a frame mounted on wheels and motors for driving the wheels to move the frame. A ram tube carrying different tools at its lower end supported in a cylinder mounted on an oscillator bracket which cooperates with an oscillator slide carriage slidably mounted on shafts supported on the frame and a hydraulic cylinder mounted on the frame for moving the oscillator slide carriage along the shafts. An electric motor for moving the lower end of the ram tube in a first arcuate direction and another electric motor for moving the lower end of the ram tube in a second arcuate direction in a plane perpendicular to the plane of movement in the first arcuate direction. A hydraulic cylinder attached to the ram tube for moving it vertically.

Abstract: An air-cooled process heat exchanger is connected to a process fired heater which uses ambient air for combustion. The exhaust air from the heat exchanger is used as preheated air to the combustion furnace, resulting in energy savings and decreased fuel consumption.