Abstract: A beam steering structure includes an alignment structure shaped to receive and align an optical fiber such that an axis of a core of the optical fiber is oriented in a first direction. The beam steering structure includes an end portion having an angled optical surface oriented at a non-zero angle relative to the first direction. The end portion is shaped and positioned so that light propagating along the first direction from the optical fiber passes through the end portion to reach the angled optical surface. A reflecting system is positioned on the angled optical surface across the first direction. The reflecting system is configured to reflect incident light propagating along the first direction into a first reflected beam of a first polarization and a second reflected beam of a second polarization. The first and second reflected beams are directed into first and second optical communication channels, respectively.

Abstract: Compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases.

Abstract: An inspection system for in situ evaluation of an additive manufacturing (AM) build part is provided. The inspection system comprises a build plane induction coil sensor configured and positionable so that during construction of the build part, the sensor's magnetization and sensor coils surround at least the last-produced layer of the AM build part in the build plane. The inspection system further comprises an energization circuit and a central processing system. The central processing system comprises a communication processor configured for sending command signals to the energization circuit and receiving impedance data from the build plane induction coil sensor, and energization controller configured for determining energization commands for transmission to the energization circuit, and an induction data analyzer configured for processing build part impedance data using complex impedance plane analysis and for identifying anomalies in the AM build part.

Abstract: An electro-optic combiner includes a polarization splitter and rotator (PSR) that directs a portion of incoming light having a first polarization through a first optical waveguide (OW). The PSR rotates a portion of the incoming light having a second polarization to the first polarization to provide polarization-rotated light. The PSR directs the polarization-rotated light through a second OW. Each of the first and second OW's has a respective combiner section. The first and second OW combiner sections extend parallel to each other and have opposite light propagation directions. A plurality of ring resonators is disposed between the combiner sections of the first and second OW's and within an evanescent optically coupling distance of both the first and second OW's. Each of ring resonators operates at a respective resonant wavelength to optically couple light from the combiner section of the first OW into the combiner section of the second OW.

Abstract: The present disclosure relates to a question recommendation system that intelligently optimizes a survey being created by a user by providing customized suggestions. For example, in one or more embodiments, the question recommendation system provides a suggested question based on questions previous added by a user while creating a survey. In particular, the question recommendation system provides various recommendations to the user to further optimize a survey being created. For instance, the question recommendation system provides recommendations with respect to improving question ordering, question phrasing, and question type as well as recommends removing potentially inefficient questions.

Abstract: Methods and systems for managing a premises are described. A premises or devices at a premises may be associated with one or more premises zones. The one or more premises zones may be associated with corresponding content. If data is received from a device associated with a particular premises zone, then the content may be output. The content may be used to notify a user of an event, state change, or other indication associated with the particular premises zone.

Abstract: A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.

Abstract: A system for improving patient outcomes for musculoskeletal care that utilizes an algorithm trained using images of musculoskeletal pathology. The system can include numerous models where each model can be trained with images from MRIs, CT Scans, X-Rays, and PET scans, or any other existing imaging technology capable of imaging a patient's musculoskeletal pathology. The system can annotate the images to generate reports with the annotations for further use in diagnosing a disease or reporting to an insurance provider.

Abstract: Devices for treating uterine bleeding. An actuator is configured to receive an input to deploy an intrauterine portion of the device to assume a larger outer profile within the uterus. The actuator may be coupled to a device body and configured to receive a pull input, a push input, or a twist input. The intrauterine portion may include flexible opposing members, rotatable tines, a segmented hook, an adjustable loop, or compressible foam. The intrauterine portion defines a lumen and suction ports configured to draw suction within the uterus. Indicia may be provided on the actuator to indicate an extent by which the intrauterine portion has been deployed within the uterus. An orientation of the actuator may correspond to a direction of deployment of the intrauterine portion. The device may include valves and an auxiliary suction source configured to provide suction with the device decoupled from a vacuum source.

Abstract: In a method of applying a weld to a target surface, a guide rail arrangement is attached to the target, the guide rail arrangement including at least one guide rail. A weld head carriage having a carriage housing, a rail follower assembly, and a sonotrode is movably mounted to the guide rail arrangement so that the follower assembly engages each guide rail for movement there-along. The weld head carriage is positioned adjacent the target surface, feedstock material is deposited onto the target surface, and the sonotrode is extended to engage the deposited feedstock material and apply a welding force to the feedstock material and the target. Relative movement between the carriage and the guide rail arrangement is initiated and ultrasonic vibrations are conducted into the feedstock material and the target, thereby welding the feedstock material to the target surface.

Abstract: Methods and systems for managing a premises are described. A premises or devices at a premises may be associated with one or more premises zones. The one or more premises zones may be associated with corresponding content. If data is received from a device associated with a particular premises zone, then the content may be output. The content may be used to notify a user of an event, state change, or other indication associated with the particular premises zone.

Abstract: A plate for attaching to an anatomic structure with fasteners. The plate has a body with a top surface and a bottom surface opposite the top surface. The body defines one or more openings to receive a respective one of the one or more fasteners. The bottom surface is concave to define a space to accommodate a portion of the anatomic structure. A bone pad surface extends from the bottom surface. A spike extends away from the bone pad surface. An extension arm can be coupled to the plate and the extension arm can support a tracking head to implement a surgical tracking assembly.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: A beam steering structure includes an alignment structure shaped to receive and align an optical fiber such that an axis of a core of the optical fiber is oriented in a first direction. The beam steering structure includes an end portion having an angled optical surface oriented at a non-zero angle relative to the first direction. The end portion is shaped and positioned so that light propagating along the first direction from the optical fiber passes through the end portion to reach the angled optical surface. A reflecting system is positioned on the angled optical surface across the first direction. The reflecting system is configured to reflect incident light propagating along the first direction into a first reflected beam of a first polarization and a second reflected beam of a second polarization. The first and second reflected beams are directed into first and second optical communication channels, respectively.

Abstract: The present disclosure relates to methods and systems for coating pharmaceutical vessels, e.g. with a coating set that includes an oxygen barrier layer, that reduce the amount of particles present on the coated vessels. The present disclosure also relates to methods and systems for removing particles from vessels, e.g. after a coating is applied to an inner surface of the vessel. The present disclosure also relates to methods and systems for inspecting pharmaceutical vessels for particles prior to filling using machine based visual analysis. Each of the above may be controlled and performed by one or more processors, thereby enabling a fully automated coating, cleaning, and/or inspecting operation for pharmaceutical vessels.

Abstract: An electro-optic combiner includes a polarization splitter and rotator (PSR) that directs a portion of incoming light having a first polarization through a first optical waveguide (OW). The PSR rotates a portion of the incoming light having a second polarization to the first polarization to provide polarization-rotated light. The PSR directs the polarization-rotated light through a second OW. Each of the first and second OW's has a respective combiner section. The first and second OW combiner sections extend parallel to each other and have opposite light propagation directions. A plurality of ring resonators is disposed between the combiner sections of the first and second OW's and within an evanescent optically coupling distance of both the first and second OW's. Each of ring resonators operates at a respective resonant wavelength to optically couple light from the combiner section of the first OW into the combiner section of the second OW.

Abstract: Systems and methods include creating a graph of a network having i) vertices representing ports, and ii) edges representing possible connections between vertices; receiving a request for one or more paths in the network; traversing the graph to determine the one or more paths; responsive to encountering a non-local constraint in the graph, adding a traversal state based thereon; and responsive to satisfying the non-local constraint in the graph, removing the traversal state based thereon.

Abstract: Systems, methods, and devices for managing sensor event rules are described. Methods may comprise determining a sensor event rule, wherein the sensor event rule comprises a rule sensor identifier and a rule event identifier. Data indicative of a sensor event may be received. The data may be associated with a first premises device. The data may further indicate an identifier of the first premises device and an identifier of a sensor event. Based on determining that the identifier of the rule sensor identifier corresponds to the identifier of the first premises device and that the rule event identifier corresponds to the identifier of the sensor event, a control signal may be transmitted to a second premise device. The control signal may be configured to cause configuration of one or more settings associated with one or more functions of the second premises device.

Abstract: Disclosed is an improved approach for translating entity prioritization rules to a continuous numerical space. In some embodiments, the approach provided is a system for using qualitative prioritization criteria to train a system that generates quantitative urgency scores for entities. In some embodiments, this comprises an embedding scheme that enables the translation of entity information and their related alerts to a set of qualitative labels based on at least quantitative information. Generally, the system includes a set of analyst actions that establish desired mappings which are used to train a more general model that maps entity embeddings to responses. In some embodiments, the approach comprises one or more models that receive an entity embedding as an input and outputs a score that characterizes the urgency of the response warranted for that entity. In some embodiments, this is performed using various features (e.g., importance, actor type, velocity, and breadth).

Abstract: A graspable handle which incorporates a force indicator with attachment to secure said device to provide resistance for purposes of exercise.