Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases.

Abstract: An optical input polarization management device includes a polarization splitter and rotator (PSR) that directs a portion of incoming light having a first polarization through a first optical waveguide (OW). The PSR rotates a portion of the incoming light having a second polarization to the first polarization so as to provide polarization-rotated light. The PSR directs the polarization-rotated light through a second OW. Light within the first and second OW's is input to a first two-by-two optical splitter (2×2OS). A first phase shifter (PS) is interfaced with either the first or second OW. Light is output from the first 2×2OS into a third OW and a fourth OW. Light within the third and fourth OW's is input to a second 2×2OS. A second PS is interfaced with either the third or fourth OW. Light is output from the second 2×2OS into a fifth OW for further processing.

Abstract: A hardware trojan security system may perform a computer implemented method to secure an electronic facility in relation to a hardware trojan, by performing a trojan vulnerability analysis, locating an instrument site location, identifying a selected instrument in relation to an effect of the trojan, marking instrument control-side markers and instrument operative-side markers, marking facility model control-side markers and facility model operative-side markers, marking access architecture control-side markers, and connecting the instrument with the facility model and access architecture by matching corresponding markers.

Abstract: A method for providing data connectivity for a passenger in a commercial passenger vehicle is provided.

Abstract: Systems and methods include creating a graph of a network having i) vertices representing ports, and ii) edges representing possible connections between vertices; receiving a request for one or more paths in the network; traversing the graph to determine the one or more paths; responsive to encountering a non-local constraint in the graph, adding a traversal state based thereon; and responsive to satisfying the non-local constraint in the graph, removing the traversal state based thereon.

Abstract: Disclosed is an improved approach for translating entity prioritization rules to a continuous numerical space. In some embodiments, the approach provided is a system for using qualitative prioritization criteria to train a system that generates quantitative urgency scores for entities. In some embodiments, this comprises an embedding scheme that enables the translation of entity information and their related alerts to a set of qualitative labels based on at least quantitative information. Generally, the system includes a set of analyst actions that establish desired mappings which are used to train a more general model that maps entity embeddings to responses. In some embodiments, the approach comprises one or more models that receive an entity embedding as an input and outputs a score that characterizes the urgency of the response warranted for that entity. In some embodiments, this is performed using various features (e.g., importance, actor type, velocity, and breadth).

Abstract: A graspable handle which incorporates a force indicator with attachment to secure said device to provide resistance for purposes of exercise.

Abstract: The present disclosure relates to methods for preparing derivatives of peptides and proteins, including preparing sialylglycosylated peptides and proteins, and to the resulting derivatives of peptides and proteins and their uses. The disclosure further relates to methods of reducing fibrillation of a peptide or protein by preparing derivatives of said peptides or proteins. The disclosure further relates to stable analogues of peptides and proteins, in particular stable insulin and glucagon analogues, which find use in methods of preparing derivatives of said peptides and proteins.

Abstract: Approaches for foil-based metallization of solar cells and the resulting solar cells are described. For example, a method of fabricating a solar cell involves locating a metal foil above a plurality of alternating N-type and P-type semiconductor regions disposed in or above a substrate. The method also involves laser welding the metal foil to the alternating N-type and P-type semiconductor regions. The method also involves patterning the metal foil by laser ablating through at least a portion of the metal foil at regions in alignment with locations between the alternating N-type and P-type semiconductor regions. The laser welding and the patterning are performed at the same time.

Abstract: Systems and methods include, responsive to defining a routing graph that includes vertices for each node of a plurality of nodes in a network and edges for links interconnecting the plurality of nodes, receiving a request for k shortest paths, where k is an integer>0, between a source node and a destination node of the plurality of nodes; and determining the k shortest paths utilizing a k-shortest path algorithm that utilizes two threads in parallel for each shortest path query, wherein the two threads include i) a shortest path query from the source node to the destination node and ii) a shortest path query from the destination node to the source node. The determining further includes, responsive to a first thread in each shortest path query obtaining a result, utilizing the result from the first thread and terminating a second thread.

Abstract: Systems and methods include receiving network data from a network; estimating large flows from the network data utilizing a first statistical approach; responsive to the network being large flow dominant, recursively estimating flows in the network utilizing the first statistical approach until an exit condition is reached; and combining the recursively estimated flows and forming a traffic matrix based thereon. The recursively estimating flows can include estimating a set of large flows utilizing the first statistical approach and freezing a resulting estimate while leaving smaller flows unsolved; repeating the estimating for a next set of large flows from the unsolved smaller flows; and continuing the repeating until the exit condition is reached.

Abstract: Systems and methods include receiving network topology information of a network including a plurality of routers; receiving link measurements defining bandwidth on links in the network; determining routes in the network based on the network topology information; and utilizing the routes and the link measurements to determine an estimate of an initial traffic matrix that includes the bandwidth between origin routers and destination routers.

Abstract: A person can use a portable electronic device to electronically purchase or otherwise request a product, service or other deliverable related to audio programming to which the person is listening at the time they initiate the request. The request is fulfilled by a service that analyzes the audio content to identify the deliverable the person desires.

Abstract: Systems and methods include creating a graph of a network having i) vertices representing ports, and ii) edges representing possible connections between vertices; receiving a request for one or more paths in the network; traversing the graph to determine the one or more paths; responsive to encountering a non-local constraint in the graph, adding a traversal state based thereon; and responsive to satisfying the non-local constraint in the graph, removing the traversal state based thereon.

Abstract: Systems and methods for constrained path computation in networks with connectivity and resource availability rules build the necessary constraints directly into the routing graph so that all paths found are by construction satisfying of all the constraints. This is in contrast to the conventional approach of finding multiple paths and then applying the constraints. The present disclosure efficiently addresses the necessary constraints in the routing graph. Path Computation Engine (PCE) performance in terms of time to return acceptable paths to the user generically degrades as network scale (typically expressed through length and number of paths) increases. The present disclosure keeps the input graph small even though the graphs have expanded functionality to address constraints.

Abstract: Systems and methods include receiving network topology information of a network including a plurality of routers; receiving link measurements defining bandwidth on links in the network; determining routes in the network based on the network topology information; and utilizing the routes and the link measurements to determine an estimate of an initial traffic matrix that includes the bandwidth between origin routers and destination routers.

Abstract: Systems and methods include receiving a request for a path from a source node to a destination node in a network with the request including N unordered inclusion nodes, N?1; adding a virtual vertex in a graph with edges connected to each of the N inclusion nodes, wherein the graph includes the virtual vertex, vertices representing nodes in the network, and edges representing links; determining a shortest path from the source node to the virtual vertex and removing an edge from a first inclusion node, that is on the shortest path, from the virtual vertex; if N>1, determining a shortest path N times to find path segments between the N inclusion nodes, removing an edge from each of the N inclusion nodes from the virtual vertex when on a corresponding shortest path; and determining a shortest path from a last inclusion node to the destination node.

Abstract: A portable camera may be activated in response to the activity of a firearm. Furthermore, an individual who discharged a firearm may be identified. Furthermore, information related to the firing of a firearm may be recorded, assessed, identified and transmitted. Furthermore, the status of an implement at a mount may be monitored. Furthermore, a charging device for delivering electrical power to components of a firearm may be used. A communications channel may be established between a firearm telematics sensor and a video camera, optionally by means of intermediary devices. A communications channel may be established between a mount (e.g., holster) telematics device and local and/or remote monitoring service components, optionally by means of intermediary devices. When the telematics sensor detects that its associated firearm has been removed from a holster, is in motion, or is being discharged, the telematics sensor may signal the video camera to initiate recording.

Abstract: Approaches for foil-based metallization of solar cells and the resulting solar cells are described. For example, a method of fabricating a solar cell involves locating a metal foil above a plurality of alternating N-type and P-type semiconductor regions disposed in or above a substrate. The method also involves laser welding the metal foil to the alternating N-type and P-type semiconductor regions. The method also involves patterning the metal foil by laser ablating through at least a portion of the metal foil at regions in alignment with locations between the alternating N-type and P-type semiconductor regions. The laser welding and the patterning are performed at the same time.

Abstract: A canopy fragilization system for use in an aircraft ejection system may comprise: a sharp breaker disposed on a first side of an ejection seat, the sharp breaker configured to act as a primary breaker of a canopy of an aircraft; a blunt breaker disposed on a second side of the ejection seat, the blunt breaker configured to act as a secondary breaker of the canopy of the aircraft; and a deployable overhead protection assembly comprising a mitt extending forward of the sharp breaker and the blunt breaker when in a deployed position, a forward end of the mitt configured to act as a tertiary breaker of the canopy of the aircraft.