Abstract: A line clamp configuration including a housing, a body attached to the housing, the body having a line contact surface, and a releaser disposed to separate the body from the housing. A control line clamp configuration including a downhole tool housing, an operable component of the downhole tool movable relative to the tool housing, a depending member on the operable component, a clamp body fastened to the housing by the depending member, a control line being releasable by removing the depending member from the clamp body. A control line clamp configuration including a split ring, a clamp body closing the split ring, and a switch to release the clamp body upon receipt of a signal. A borehole system including a borehole in a subsurface formation, a tool in the borehole, a clamp configuration operably connected to the tool.

Abstract: An inflow control device, including an upstream flow control structure configured to induce water droplet collisions, and a downstream flow control structure disposed downstream of the upstream flow control structure and comprising a channel formed therethrough. A method of controlling flow including flowing a fluid from a source to a destination through an inflow control device comprising an upstream flow control structure and a downstream flow control structure disposed downstream of the upstream flow control structure and comprising a channel formed therethrough, and inducing water droplet collisions in the upstream flow control structure. A wellbore system including a borehole in a subsurface formation, a string disposed in the borehole, and the inflow control device, disposed within or as part of the string.

Abstract: A density-based flow control configuration includes a housing and a first baffle having a first flow opening, a second baffle having a second flow opening adjacent the first baffle, one of the baffles being rotationally movable relative to the housing and to the other of the baffles, a first density float associated with the movable baffle, to impart torque to the associated baffle, the torque causing alignment or misalignment of the first and second openings. A method for allowing flow of a target fluid and choking flow of a nontarget fluid, including exposing a density-based flow control configuration to a fluid, imparting torque to a first baffle, and aligning or misaligning an opening in the first baffle with another opening to allow or choke flow of the fluid. A wellbore system, including a density-based flow control configuration.

Abstract: A fluid density valve housing includes a pilot fluid inlet and outlet and a primary fluid inlet and outlet. A shuttle is disposed within the housing. The shuttle comprises a portion having a reference density and a portion defining a cavity fluidically connected to the pilot fluid inlet, the shuttle permitting or denying primary fluid flow depending upon a density of a pilot fluid flowing through the cavity versus the reference density. A method for controlling flow, including comparing density of a pilot flow with a reference density, moving a valve between fully open, fully closed, and choked depending upon the differential density between the pilot fluid and the reference density. A borehole system, including a borehole in a subsurface formation, a string in the borehole, and a fluid density valve disposed within or as a part of the string.

Abstract: An inflow control device (ICD), including a hydrocyclonic device having a plurality of pressure taps therein and a valve responsive to differential pressure of the plurality of pressure taps. An inflow control device (ICD) including a switch having a primary flow inlet and a primary flow outlet, and a trigger that generates a differential pressure in the trigger due to separation of fluids having different densities. A method for allowing flow of a desired fluid while retarding a flow of undesired fluid in a flow control device, including flowing a pilot fluid through a fluid separator, separating components of the pilot fluid, applying differential pressure of two of the separated components to a valve that is actuated by differential pressure, flowing or retarding flow of a primary flow through the valve in response to the differential pressure.

Abstract: An inflow control device includes a first flow control structure that is porous and forms differing flowpaths for water and oil. A method of controlling flow includes flowing a fluid from a source to a destination through the inflow control device, and controlling flow via the first flow control structure such that oil flows through the inflow control device more easily than water. A method of controlling flow includes flowing a fluid from a source to a destination through the inflow control device, and flowing a portion of water in the fluid through the first flow control structure to impinge on an upstream surface of the second flow control structure. A wellbore system includes a borehole in a subsurface formation, a string disposed in the borehole, and the inflow control device disposed within or as part of the string.

Abstract: An inflow control device, including an upstream flow control structure configured to induce water droplet collisions, and a downstream flow control structure disposed downstream of the upstream flow control structure and comprising a channel formed therethrough. A method of controlling flow including flowing a fluid from a source to a destination through an inflow control device comprising an upstream flow control structure and a downstream flow control structure disposed downstream of the upstream flow control structure and comprising a channel formed therethrough, and inducing water droplet collisions in the upstream flow control structure. A wellbore system including a borehole in a subsurface formation, a string disposed in the borehole, and the inflow control device, disposed within or as part of the string.

Abstract: An inflow control device includes a first flow control structure that is porous and forms differing flowpaths for water and oil. A method of controlling flow includes flowing a fluid from a source to a destination through the inflow control device, and controlling flow via the first flow control structure such that oil flows through the inflow control device more easily than water. A method of controlling flow includes flowing a fluid from a source to a destination through the inflow control device, and flowing a portion of water in the fluid through the first flow control structure to impinge on an upstream surface of the second flow control structure. A wellbore system includes a borehole in a subsurface formation, a string disposed in the borehole, and the inflow control device disposed within or as part of the string.

Abstract: An inflow control device (ICD), including a hydrocyclonic device having a plurality of pressure taps therein and a valve responsive to differential pressure of the plurality of pressure taps. An inflow control device (ICD) including a switch having a primary flow inlet and a primary flow outlet, and a trigger that generates a differential pressure in the trigger due to separation of fluids having different densities. A method for allowing flow of a desired fluid while retarding a flow of undesired fluid in a flow control device, including flowing a pilot fluid through a fluid separator, separating components of the pilot fluid, applying differential pressure of two of the separated components to a valve that is actuated by differential pressure, flowing or retarding flow of a primary flow through the valve in response to the differential pressure.

Abstract: A density-based flow control configuration includes a housing and a first baffle having a first flow opening, a second baffle having a second flow opening adjacent the first baffle, one of the baffles being rotationally movable relative to the housing and to the other of the baffles, a first density float associated with the movable baffle, to impart torque to the associated baffle, the torque causing alignment or misalignment of the first and second openings. A method for allowing flow of a target fluid and choking flow of a nontarget fluid, including exposing a density-based flow control configuration to a fluid, imparting torque to a first baffle, and aligning or misaligning an opening in the first baffle with another opening to allow or choke flow of the fluid. A wellbore system, including a density-based flow control configuration.

Abstract: A line clamp configuration including a housing, a body attached to the housing, the body having a line contact surface, and a releaser disposed to separate the body from the housing. A control line clamp configuration including a downhole tool housing, an operable component of the downhole tool movable relative to the tool housing, a depending member on the operable component, a clamp body fastened to the housing by the depending member, a control line being releasable by removing the depending member from the clamp body. A control line clamp configuration including a split ring, a clamp body closing the split ring, and a switch to release the clamp body upon receipt of a signal. A borehole system including a borehole in a subsurface formation, a tool in the borehole, a clamp configuration operably connected to the tool.

Abstract: A line clamp configuration including a housing, a body attached to the housing, the body having a line contact surface, and a releaser disposed to separate the body from the housing. A control line clamp configuration including a downhole tool housing, an operable component of the downhole tool movable relative to the tool housing, a depending member on the operable component, a clamp body fastened to the housing by the depending member, a control line being releasable by removing the depending member from the clamp body. A control line clamp configuration including a split ring, a clamp body closing the split ring, and a switch to release the clamp body upon receipt of a signal. A borehole system including a borehole in a subsurface formation, a tool in the borehole, a clamp configuration operably connected to the tool.

Abstract: A fluid density valve housing includes a pilot fluid inlet and outlet and a primary fluid inlet and outlet. A shuttle is disposed within the housing. The shuttle comprises a portion having a reference density and a portion defining a cavity fluidically connected to the pilot fluid inlet, the shuttle permitting or denying primary fluid flow depending upon a density of a pilot fluid flowing through the cavity versus the reference density. A method for controlling flow, including comparing density of a pilot flow with a reference density, moving a valve between fully open, fully closed, and choked depending upon the differential density between the pilot fluid and the reference density. A borehole system, including a borehole in a subsurface formation, a string in the borehole, and a fluid density valve disposed within or as a part of the string.

Abstract: The present application relates to immunomodulatory molecules comprising a first binding domain (e.g., immunostimulatory cytokine such as IL-2 or IL-12 or variant thereof) specifically recognizing a first target molecule (e.g., receptor of immunostimulatory cytokine) and a second binding domain (e.g., agonist ligand such as PD-L1 or PD-L2 or variant thereof, or agonist antigen-binding fragment such as anti-PD-1 agonist Fab, scFv, VHH, or full-length antibody) specifically recognizing a second target molecule (e.g., inhibitory checkpoint molecule such as PD-1), wherein the first binding domain upon binding to the first target molecule up-regulates an immune response, and wherein the second, binding domain upon binding to the second target molecule down-regulates the immune response. Methods of making and uses of such immunomodulatory molecules are also provided.

Abstract: A clamp for a line including a body, and a control line contact surface, the clamp being responsive to a selected input to facilitate displacement of the line. An expandable tool including a component having a first dimension prior to activation and a second dimension after activation, a control line disposed adjacent the component, and a clamp initially securing the control line, the clamp comprising at least one of 1) a fastener and 2) a body, at least a portion of either of which being responsive to a selected input to facilitate displacement of the control line. A method for deploying a tool with a control line including securing the control line to the tool, reacting the at least a portion of the clamp to the input, and displacing the control line. A borehole system including a borehole in a formation, and an expandable tool disposed in the borehole.

Abstract: The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.

Abstract: A line clamp configuration including a housing, a body attached to the housing, the body having a line contact surface, and a releaser disposed to separate the body from the housing. A control line clamp configuration including a downhole tool housing, an operable component of the downhole tool movable relative to the tool housing, a depending member on the operable component, a clamp body fastened to the housing by the depending member, a control line being releasable by removing the depending member from the clamp body. A control line clamp configuration including a split ring, a clamp body closing the split ring, and a switch to release the clamp body upon receipt of a signal. A borehole system including a borehole in a subsurface formation, a tool in the borehole, a clamp configuration operably connected to the tool.

Abstract: A clamp for a line including a body, and a control line contact surface, the clamp being responsive to a selected input to facilitate displacement of the line. An expandable tool including a component having a first dimension prior to activation and a second dimension after activation, a control line disposed adjacent the component, and a clamp initially securing the control line, the clamp comprising at least one of 1) a fastener and 2) a body, at least a portion of either of which being responsive to a selected input to facilitate displacement of the control line. A method for deploying a tool with a control line including securing the control line to the tool, reacting the at least a portion of the clamp to the input, and displacing the control line. A borehole system including a borehole in a formation, and an expandable tool disposed in the borehole.

Abstract: The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.

Abstract: The disclosure provides for compositions, methods, and kits for evaluating the effect of a cell-killing agent on a population of tumor cells (e.g., tumor cells that can inducibly express reporter protein).