Abstract: The present invention relates to novel molecules that can be employed for the prevention, alleviation, treatment and/or diagnosis of diseases, disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, aSynuclein, A-syn, ?-syn, aSyn, a-syn) aggregates, including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease, Multiple System Atrophy, Lewy Body dementia (LBD; dementia with Lewy bodies (DLB) (“pure” Lewy body dementia), Parkinson's disease dementia (FDD)) or Diffuse Lewy Body Disease. The invention relates to alpha-synuclein binding molecules, in particular to alpha-synuclein antibodies or an antigen-binding fragment or a derivative thereof and uses thereof.

Abstract: The present invention relates to biparatopic antigen-binding molecules, such as biparatopic antibodies or functional fragments thereof, and mixtures comprising at least two monospecific antibodies or functional fragments thereof, that can be employed for the prevention, alleviation, treatment and/or diagnosis of diseases, disorders and abnormalities associated with CNS proteins such as alpha-synuclein (?-synuclein, A-synuclein, aSynuclein, A-syn, ?-syn, aSyn, a-syn), Tau, TDP-43, ASC, NLRP3, C5a, C1q, C3, huntingtin or prion protein.

Abstract: The present invention relates to novel molecules that can be employed for the prevention, alleviation, treatment and/or diagnosis of diseases, disorders and abnormalities associated with alpha-synuclein (?-synuclein, A-synuclein, aSynuclein, A-syn, ?-syn, aSyn, a-syn) aggregates, including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease, Multiple System Atrophy, Lewy Body dementia (LBD; dementia with Lewy bodies (DLB) (“pure” Lewy body dementia), Parkinson's disease dementia (PDD)) or Diffuse Lewy Body Disease. The invention relates to alpha-synuclein binding molecules, in particular to alpha-synuclein antibodies or an antigen-binding fragment or a derivative thereof and uses thereof.

Abstract: The present invention provides methods for preparing the nut waste pot composites from a nut waste component, one or more binders, and an oil using a compounder/extruder.

Abstract: Compounds are identified that act as crystallization suppressants when added to clear brine fluids, significantly lowering the true crystallization temperatures of the brines, and allowing for higher salt content in clear brine fluids. The crystallization suppressants of the invention also allow for the preparation of higher density zinc free brines. Crystallization suppressant blends are also identified that allow for the preparation of high density clear brine fluids with lower viscosities.

Abstract: The present invention provides methods for preparing the nut waste pot composites from a nut waste component, one or more binders, and an oil using a compounder/extruder.

Abstract: The present invention relates to novel molecules that can be employed for the prevention, alleviation, treatment and/or diagnosis of diseases, disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, aSynuclein, A-syn, ?-syn, aSyn, a-syn) aggregates, including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease, Multiple System Atrophy, Lewy Body dementia (LBD; dementia with Lewy bodies (DLB) (“pure” Lewy body dementia), Parkinson's disease dementia (FDD)) or Diffuse Lewy Body Disease. The invention relates to alpha-synuclein binding molecules, in particular to alpha-synuclein antibodies or an antigen-binding fragment or a derivative thereof and uses thereof.

Abstract: The present invention provides methods for preparing the nut waste sheet composites from a nut waste component and one or more binders.

Abstract: The present invention provides compositions comprising the reaction product of an aliphatic diisocyanate, and a reactive intermediate made from one selected from the group consisting of oxazolidinones, benzoic sulfimides (saccharins), 1H-indole-2,3-diones (isatins), succinamides, N-hydroxysuccinamides, 4-hydroxy-3-methoxybenzaldehydes (vanillins), ?-ketoamides, piperazines, benzofuranones, 3,4-dihydroxycyclobut-3-ene-1,2-diones (squaric acids), squaric acid esters, ?-ketoamides, anilines, and ?-ketoamide, phenols. The aliphatic diisocyanate comprises one selected from the group consisting of isocyanurates, biurets, iminooxadiazine diones, urethanes, uretdiones, carbodiimides, and allophanates. The resulting compositions may be useful in producing coatings, adhesives, sealants, castings, composites and films having durability, color stability, high gloss, and chemical resistance properties similar to those made from polyurethane.

Abstract: The present invention provides methods for preparing the nut waste sheet composites from a nut waste component and one or more binders.

Abstract: The present application discloses heteroaromatic and heterobicyclic aromatic derivative compounds and compositions, and methods for treating ferroptosis-related disorders and diseases inpatients using the compounds and compositions as disclosed herein.

Abstract: The present disclosure relates to paint mixing devices, and more specifically to a paint mixing device comprising a shaft portion and a clamp portion. The clamp portion of the disclosed mixing devices is capable of receiving a disposable paint stirrer. The shaft of the disclosed devices is sized to be received by commercially available power drills and electric screwdrivers. The disclosed device advantageously facilitate the mixing of paint by a disposable paint stirrer at revolutions per minute not achievable by hand-mixing.

Abstract: Compounds are identified that act as crystallization suppressants when added to clear brine fluids, significantly lowering the true crystallization temperatures of the brines, and allowing for higher salt content in clear brine fluids. The crystallization suppressants of the invention also allow for the preparation of higher density zinc free brines.

Abstract: Compounds are identified that act as crystallization suppressants when added to clear brine fluids, significantly lowering the true crystallization temperatures of the brines, and allowing for higher salt content in clear brine fluids. The crystallization suppressants of the invention also allow for the preparation of higher density zinc free brines. Crystallization suppressant blends are also identified that allow for the preparation of high density clear brine fluids with lower viscosities.

Abstract: This disclosure relates to DNA double-write/double binding identity, and the design and use of DNA double-write materials and methods in processes and systems for macro, micro, and nano-photolithography and self-assembly processes for carrying out two and three dimensional nanofabrication.

Abstract: Compounds are identified that act as crystallization suppressants when added to clear brine fluids, significantly lowering the true crystallization temperatures of the brines, and allowing for higher salt content in clear brine fluids. The crystallization suppressants of the invention also allow for the preparation of higher density zinc free brines. Crystallization suppressant blends are also identified that allow for the preparation of high density clear brine fluids with lower viscosities.

Abstract: The present invention provides compositions comprising the reaction product of an aliphatic diisocyanate, and a reactive intermediate made from one selected from the group consisting of oxazolidinones, benzoic sulfimides (saccharins), 1H-indole-2,3-diones (isatins), succinamides, N-hydroxysuccinamides, 4-hydroxy-3-methoxybenzaldehydes (vanillins), ?-ketoamides, piperazines, benzofuranones, 3,4-dihydroxycyclobut-3-ene-1,2-diones (squaric acids), squaric acid esters, ?-ketoamides, anilines, and ?-ketoamide, phenols. The aliphatic diisocyanate comprises one selected from the group consisting of isocyanurates, biurets, iminooxadiazine diones, urethanes, uretdiones, carbodiimides, and allophanates. The resulting compositions may be useful in producing coatings, adhesives, sealants, castings, composites and films having durability, color stability, high gloss, and chemical resistance properties similar to those made from polyurethane.