Abstract: The present disclosure relates to an aqueous formulation comprising as an active ingredient a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof, poloxamer, and an aqueous carrier, wherein the aqueous formulation is in the form of a suspension formulation.

Abstract: Methods and systems for rotationally aligning cusps of a prosthetic heart valve with cusps of a native valve are disclosed. As one example, a method includes advancing a distal end portion of a delivery apparatus toward a native valve of a heart, a prosthetic heart valve radially compressed around the distal end portion, and visualizing under fluoroscopy, within an imaging view, a position one or more radiopaque markers disposed on the distal end portion relative to one or more native valve cusps. The method further includes rotating the distal end portion until the one or more markers are circumferentially aligned with a middle of the one or more native valve cusps and deploying the radially compressed prosthetic heart valve with the delivery apparatus to radially expand the prosthetic heart valve in the native valve such that the cusps of the prosthetic heart valve and the native valve are circumferentially aligned.

Abstract: The present disclosure relates to an aqueous formulation comprising as an active ingredient a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof, poloxamer, and an aqueous carrier, wherein the aqueous formulation is in the form of a suspension formulation.

Abstract: A negative pressure wound therapy device can be configured to monitor motion and determine that the device is falling as well as duration and height of the fall. Flat falls and rotating falls can be accurately detected. The device can provide an indication of the fall, including deactivating therapy. The device can monitor the amount exudate removed from a wound and determine whether transition to a low-exudate rate negative pressure wound therapy and suggest such transition. The device can utilize proportional-inte-gral-derivative (PID) control loop to drive a negative pressure source of the device. The PID control loop can utilize different proportional gain and integral gain for different negative pressure setpoint to achieve target pressure quickly and without any large overshoots.

Abstract: A negative pressure device having a negative pressure source, a canister in fluid communication with the negative pressure source, a conduit the can couple with a wound dressing to provide negative pressure to a space beneath the wound dressing. Some arrangements of the negative pressure source can have a first noise reduction chamber and a second noise reduction chamber downstream of and in fluid communication with an outlet of a pump. The first and second noise reduction chambers can be configured to reduce noise generated by the pump and/or a level of pressure pulses in the fluid that is advanced through the negative pressure source.

Abstract: A method of reducing an effect of known computer based skills in a backgammon game includes the steps of arranging the playing pieces from farthest from home to closest to home in stacks of 1, 2, 3, 4 and 5 playing pieces, respectively, for each of a first player and a second player, and using at least two dice for each roll such that each of the first player and the second player is enabled to make at least two moves after each roll of the dice.

Abstract: Certain embodiments of the disclosure are related to compositions and methods for producing proteins of interest in pigment deficient Bacillus cells. Certain other embodiments are related to compositions and methods for obtaining pigment deficient Bacillus cells. Certain other embodiments are related to compositions and methods for growing/cultivating/fermenting pigment deficient Bacillus cells. Certain other embodiments are therefore related to compositions and methods for producing, isolating, recovering and the like proteins of interest that are pigment deficient.

Abstract: An electronic assembly includes a substrate having a die and PCB mounted thereon. Wirebonds interconnect bond pads of the die with contact pads of the PCB, each wirebond having a first end portion bonded to a respective bond pad, an opposite second end portion bonded to a respective contact pad and an intermediate section extending between the first and second end portions. A dam encapsulant encapsulates each of the first and second end portions, a first fill encapsulant contacts the substrate and the dam encapsulant; and a second fill encapsulant overlies the first fill encapsulant. The first fill encapsulant has a lower modulus of elasticity than the second fill encapsulant and the dam encapsulant.

Abstract: A computer processing system includes a processor to operate in a first computing environment. The processor creates a generic application layer by scrubbing a new application layer within the computer processing system to remove objects associated with the new application layer and specific to the first computing environment. The processor further creates within the computer processing system a single composited layered image by merging the generic application layer with at least one other application layer having objects associated therewith.

Abstract: A negative pressure wound therapy device can include a negative pressure source configured to be connected, via a fluid flow path, to a wound, a valve positioned in the fluid flow path and configured to, in an open state, permit supply of negative pressure from the negative pressure source upstream of the valve and, in a closed state, block supply of negative pressure from the negative pressure source upstream of the valve, a flow restrictor positioned in the fluid flow path, and a pressure sensor configured to measure a pressure differential across the flow restrictor. The device can include control circuitry configured to, in a normal operational mode, cause the valve to be in the open state and, in a test mode, perform at least one of a leak test, a flow test, or an excessive pressure test.

Abstract: The present disclosure relates to an aqueous formulation comprising as an active ingredient a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof, poloxamer, and an aqueous carrier, wherein the aqueous formulation is in the form of a suspension formulation.

Abstract: A computer processing system includes a processor to operate in a first computing environment. The processor creates a generic application layer by scrubbing a new application layer within the computer processing system to remove objects associated with the new application layer and specific to the first computing environment. The processor further creates within the computer processing system a single composited layered image by merging the generic application layer with at least one other application layer having objects associated therewith.

Abstract: Application layering is a technology that separates applications from an operating system image. In some cases, information inside an application layer needs to be modified when that layer is delivered to a computer to be executed correctly in a specific environment. Described is a technique to allow those operations to be defined and executed outside of the operating system that will be running the application layer, so that a single application layer can be delivered to heterogeneous end points without the need to take up additional computation on the guest machine it is being delivered to, to ensure application compatibility when applications reside in more than one layer, to install applications into a layer without knowledge of a specific platform, and to modify the image to provide the required drivers and services to support any platform.

Abstract: An electronic assembly includes a substrate having a die and PCB mounted thereon. Wirebonds interconnect bond pads of the die with contact pads of the PCB, each wirebond having a first end portion bonded to a respective bond pad, an opposite second end portion bonded to a respective contact pad and an intermediate section extending between the first and second end portions. A dam encapsulant encapsulates each of the first and second end portions, a first fill encapsulant contacts the substrate and the dam encapsulant; and a second fill encapsulant overlies the first fill encapsulant. The first fill encapsulant has a lower modulus of elasticity than the second fill encapsulant and the dam encapsulant.

Abstract: Methods for locating blood vessels, lesions, and other discontinuities in tissue such as, but not limited to, the greater palatine artery (GPA) in the hard palate using an optical imaging process, surgical procedures utilizing the identified locations of discontinuities, and devices suitable for use during surgical procedures. According to one aspect, such a method locates a blood vessel or lesion in tissue by imaging the tissue via a diffuse optical imaging (DOI) process that measures light that travels through the tissue, and then locates the blood vessel or lesion in the tissue based on a difference in absorption of the light between the tissue and the blood vessel or lesion.

Abstract: A server includes a processor to execute a single generic composited layered image that includes an operating system layer and an application layer. The processor hooks into the user log-in process to capture a user identification of the user initiating the log-in process, and compares the user identification to a list of additional application layers that are to be available to different users based on their respective user identifications. The processor determines if at least one additional application layer is to be available to the user based on the compare, and creates a single user-specific composited layered image by mounting the at least one additional application layer to the single generic composited layered image if the at least one additional application layer is to be available to the user.

Abstract: A composite structural member for a building structure comprises a first elongate portion having a first end region and a second end region and a second elongate portion having a first end region and a second end region. The second end region of the first elongate portion is connected to the first end region of the second elongate portion so that the composite structural member provided thereby is substantially longer than either of the first and second elongate portions. The first elongate portion may comprise a first member suited for resisting high magnitude forces and the second elongate portion may be a second member, less well suited for resisting high forces but having lower cost per unit length. The composite structural member may be a rafter, especially a rafter of a portal frame.

Abstract: A server includes a processor to execute a single generic composited layered image that includes an operating system layer and an application layer. A layering engine hooks into the user log-in process to capture a user identification of the user initiating the log-in process, and compares the user identification to a list of additional application layers that are to be available to different users based on their respective user identifications. The layering engine determines if at least one additional application layer is to be available to the user based on the compare, and creates a single user-specific composited layered image by mounting the at least one additional application layer to the single generic composited layered image if the at least one additional application layer is to be available to the user.

Abstract: A gooseneck trailer having an elevated hopper at the forward end thereof and a deck at the rearward end of the trailer for supporting a vehicle thereon. The hopper has a discharge opening formed in the lower end thereof at one side thereof and a discharge door, which is movable between open and closed positions, selectively closes the discharge opening. Locking devices are provided for locking the discharge door in its closed position.

Abstract: A composite structural member for a building structure comprises a first elongate portion having a first end region and a second end region and a second elongate portion having a first end region and a second end region. The second end region of the first elongate portion is connected to the first end region of the second elongate portion so that the composite structural member provided thereby is substantially longer than either of the first and second elongate portions. The first elongate portion may comprise a first member suited for resisting high magnitude forces and the second elongate portion may be a second member, less well suited for resisting high forces but having lower cost per unit length. The composite structural member may be a rafter, especially a rafter of a portal frame.