Abstract: A point-of-care system with a diagnostic tool and a base station with a display and in communication with the diagnostic tool is described. Used in diagnosing health conditions for a tissue under analysis, the diagnostic tool includes a handle and a head portion. The head portion includes a speculum and optical spectroscopy (OS) data acquisition components positioned within the head portion. The OS data acquisition components are configure to (i) emit light toward the tissue under analysis, (ii) receive light reflected at least in part from the tissue under analysis based on the emitted light, and (iii) determine reflectance spectra associated with the received light. Either the diagnostic tool or a base station includes analytic components configured to (i) generate diagnostic metrics including characteristics of the reflectance spectra and (ii) compare these characteristics to data associated with characteristics of known reflectance spectra associated healthy and/or unhealthy tissue of patients.

Abstract: A composite material for detecting and measuring levels of analytes and target molecules in biological fluid and tissue is disclosed herein. This composite material is constructed from a porous mesh sheet that is coated with a signal emitting material and is impregnated with target detecting molecules mixed inside one or multiple polymer mixtures. The geometry and configuration of different constituents can provide high efficiency of signals, the ability to measure multiple signals, small dimensions, fast response to changes, long storage lifetimes, controlled diffusional and mechanical properties, as well as easy industrial manufacturability. The composite material can be used in many sensing applications including optical or electrochemical continuous biosensing such as continuous glucose and lactate monitors.

Abstract: Systems and methods for use in detecting health condition of a physiological cavity or passageway are disclosed herein. In one example, the system may include one or more illuminators configured to illuminate a target area with light at discrete wavelengths. The system may additionally include detectors that are configured to receive a reflectance spectrum based on light emitted at discrete wavelengths from tissue and tissue constituents associated with the target area under analysis. Communicatively coupled to the one or more detectors, the processing unit is configured to analyse data associated with the reflectance spectra to produce one or more output values that identify the health condition.

Abstract: Disclosed herein are embodiments of a continuous analyte sensor that can be used to measure glucose or lactate levels in a patient, along with other analytes. In some embodiments, the sensor can be located in the tissue or a blood vessel of a patient, and a probe can be located on the skin of the patient generally adjacent to the sensor. The probe can detect luminescent signals that originate from the sensor and that are dependent on analyte levels.

Abstract: Disclosed herein are embodiments of methods and techniques for measuring oxygen levels of an implant. The implant can have a plurality of oxygen-sensitive microparticles incorporated throughout. The oxygen-sensitive microparticles can receive light and emit excitation light in response. The levels of excitation light emitted can be directly related to oxygen concentration in the implant.

Abstract: Disclosed herein are embodiments of a continuous analyte sensor that can be used to measure glucose or lactate levels in a patient, along with other analytes. In some embodiments, the sensor can be located in the tissue or a blood vessel of a patient, and a probe can be located on the skin of the patient generally adjacent to the sensor. The probe can detect luminescent signals that originate from the sensor and that are dependent on analyte levels.

Abstract: Disclosed herein are embodiments of methods and techniques for measuring oxygen levels of an implant. The implant can have a plurality of oxygen-sensitive microparticles incorporated throughout. The oxygen-sensitive microparticles can receive light and emit excitation light in response. The levels of excitation light emitted can be directly related to oxygen concentration in the implant.