Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.

Abstract: Homologs of antibiotic Lasalocid A and their pharmaceutically acceptable salts are produced by a known species of Streptomyces. The homologs exhibit coccidiostatic and antibacterial activity and thus are useful as coccidiostats and antibacterial agents.

Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.

Abstract: Methods of and compositions for improving cardiovascular function utilizing as the active agent certain pharmaceutically acceptable salts, derivatives, isomers and homologs of lasalocid (formerly known as antibiotic X-537A) are disclosed.

Abstract: A compound which is the C-17 epimer of deoxy-(0-8)-epi-17-salinomycin is produced by the fermentation of a strain of Streptomyces albus 80,614 (ATCC 21,838). The compound exhibits activity as an antimicrobial and antihypertensive agent.

Abstract: Racemic modifications of optically active primary or tertiary amines are treated with lasalocid to form diastereomeric salts. The so-formed diastereomeric salts are separated and, subsequently, can be chemically decomposed to give the desired enantiomers of the amine. The resolving agent, lasalocid, is recovered in this process by precipitation or evaporation from organic solvents.

Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.

Abstract: Methods of and compositions for improving cardiovascular function utilizing as the active agent certain pharmaceutically acceptable salts, derivatives, isomers and homologs of lasalocid (formerly known as antibiotic X-537A) are disclosed.

Abstract: Methods of, and compositions for, improving cardiovascular function utilizing as the active agent certain polyether antibiotics, their pharmaceutically acceptable salts and derivatives are disclosed.

Abstract: A new antibiotic substance X-4357B is obtained by culturing a strain of Streptomyces and recovering said substance from the fermentation mixture. The new substance possesses fungicidal, larvicidal and cytotoxic activities.

Abstract: Methods of, and compositions for, improving cardiovascular function utilizing as the active agent certain polyether antibiotics, their pharmaceutically acceptable salts and derivatives are disclosed.

Abstract: Derivatives of antibiotic X-537A of the formulaWherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, and phenyl substituted by a member of the group consisting of halogen, nitro, and lower alkyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, lower alkanoyl, ##SPC1##benzoyl, and benzoyl substituted by a member of the group consisting of halogen, nitro and lower alkyl; R.sub.5 is selected from the group consisting of phenylazo and phenylazo substituted by a member of the group consisting of halogen, nitro, lower alkyl and lower alkoxy; and R.sub.4 is selected from the group consisting of --OH, =O, and =N--OHand the pharmaceutically acceptable alkali metal, alkaline earth metal and ammonium salts thereof, together with methods for their preparation are disclosed. These derivatives are useful as coccidiostatic agents and antibacterial agents.

Abstract: Iso-lasalocid (an isomer of lasalocid A) is produced by a species of Streptomyces. The isomer, its halogen derivatives and its salts exhibit antibacterial and antiprotozoal activity and are useful as antibacterial and antiprotozoal agents.

Abstract: Compound of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, phenyl, or phenyl substituted by halogen, nitro or lower alkyl; R.sub.2 is hydrogen; lower alkyl; lower alkanoyl; benzoyl; benzoyl substituted by halogen, nitro or lower alkyl; or R.sub.3 is hydrogen, halogen; nitro, amino, loweralkylamido or lower alkylamino; R.sub.4 is --OH, =O or =NOH which compound is useful as a coccidiostatic agent and as an anti-bacterial agent.