Abstract: The present invention relates to a method for treating or preventing headache disorders selected from the group consisting of migraine, medication overuse headache, cluster headache, general headache, trigeminal neuralgia, and orofacial pain, comprising administering a therapeutically effective amount of a therapeutic agent that modulates activity of a Neurokinin Receptor 3 (“NK3”) protein or modulates expression of a TACR3 gene.

Abstract: Among other things, data is stored for each of several pharmaceuticals that are associated with a given indication. The data is representative of elements of value of the pharmaceutical including elements within the domains of clinical efficacy, safety and use, and economics. A computer is used to calculate a drug score for each of the pharmaceuticals based on the data that is representative of the elements of value. Through a user interface, the relative scores and the basis on which they were calculated are displayed to enable decisions about the pharmaceuticals.