Abstract: The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.

Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.

Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.

Abstract: The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.

Abstract: The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.

Abstract: The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).

Abstract: According to one embodiment, a route management system for an unmanned vehicle includes a network node in communication with an unmanned vehicle control system and an unmanned vehicle. The network node is operable to transmit a number of initial waypoints to the unmanned vehicle, transmit one or more in-flight waypoints to the unmanned vehicle after the unmanned vehicle has arrived at a corresponding one or more of the initial waypoints, and replace the one or more of the initial waypoints with the one or more in-flight waypoints in the unmanned vehicle such that the total quantity waypoints stored in the unmanned vehicle does not exceed a specified quantity.

Abstract: Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.

Abstract: According to one embodiment, an unmanned vehicle simulation system includes a simulator translator coupled between an unmanned vehicle control system that is operable to control an unmanned vehicle and a vehicle simulator that is operable to simulate operation of the unmanned vehicle. The simulator translator is operable to receive a message from the unmanned vehicle control system, translate the message to another message suitable for use by the vehicle simulator, and transmit the translated message to the vehicle simulator.

Abstract: A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.

Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.

Abstract: A tool and process for installing a trim clip to a mounting surface. The tool includes a handle attached to a grasping portion. The grasping portion is provided with a base that is adapted for insertion into a hollow pocket that exists within the trim clip. A pair of retaining arms are maintained at some distance above the base and extend outwardly along the length thereof. The retaining arms each include at least one spring-loaded ball that extends downward from an underside thereof. When the grasping portion is engaged with the trim clip, the trim clip is retained by the presence of the base within the pocket and by a downward force exerted on the trim clip by the spring-loaded balls. The tool can be used to easily remove a trim clip from a storage medium, install the trim clip to a mounting surface, and subsequently release the trim clip.

Abstract: A method of detecting the presence or absence of a target microorganism in a sample to be tested comprising: combining with the sample, bacteriophage capable of infecting the target microorganism to create a bacteriophage exposed sample; providing conditions to the bacteriophage exposed sample sufficient to allow the bacteriophage to infect the target microorganism to create injected bacteriophage nucleic acid, additional bacteriophage nucleic acid, intermediate bacteriophage protein, or additional bacteriophage protein; and assaying the nucleic acid or protein to determine the presence or absence of the target microorganism. The microorganism is preferably dissociated or lysed prior to the completion of the bacteriophage replication process. The sample is an insitu sample and the microorganism is isolated from the insitu matrix. The assaying comprises comparing the test nucleic acid or protein level to a reference level.

Abstract: A compact material marking system and method uses a laser to mark materials such as fabrics in environments such as stores with safety and ease of use being addressed. The system includes a housing containing the laser, gas filters, and other equipment such as fans. Material to be marked is placed into a cassette box having an opening exposing the material. The cassette is engaged with an enclosure that is coupled to the housing to allow the laser beam from the laser to enter the enclosure and to strike the material found in the engaged cassette. Fumes caused by interaction of the laser beam with the material are contained by the enclosure and drawn away to be filtered. Sensors are employed so that the laser can be activated only when the cassette is fully engaged with the enclosure.

Abstract: A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to indicate the presence of the associated target bacteria in the raw sample. In one embodiment, each phage is initially added to the raw sample in concentrations below the detection limit of the final phage detection process. In another embodiment, the parent phages are tagged in such a way that they can be separated from the progeny phage prior to the detection process. Preferred phage detection processes are immunoassay methods utilizing antibodies that bind specifically to each phage. Antibodies can be used that bind to the protein capsid of the phage. Alternatively, the phage can by dissociated after the incubation process and the sample tested for the presence of individual capsid proteins or phage nucleic acids.

Abstract: A case for a handheld computer system is described. In an embodiment, the handheld computer system comprises a personal digital assistant. The case has multi-functional capability. The case provides a protective housing for the personal digital assistant and includes a communication module which is integrated into the case for protection against damage, whereas the communication module transmits and receives data for the personal digital assistant. In an embodiment, the communication module comprises a radio frequency (RF) wireless communication device. In an embodiment, the case includes a connector which couples to a communication port located on the back of the personal digital assistant, whereas the connector couples to the personal digital assistant inserted inside the case. In an embodiment, the connector comprises a latching connector which electrically couples to the communication port and which couples to the personal digital assistant.

Abstract: An aluminum alloy containing the following elements in the stated amounts: 0.6≦Mg≦0.9; 0.25≦Si≦0.6; 0.25≦Cu≦0.9; Fe<0.4; Mn<0.4; the total of the amounts of Cu, Si and Mg being, in atomic weight percent, more than 1.2% and less than 1.8%. These alloys may be subjected to homogenization at about 470 to 560° C. for more than four hours, hot rolling at a temperature in the range of 400 to 580° C., cold rolling, solutionizing at a temperature in the range of 470 to 580° C., and natural aging at ambient temperature. The alloys may then be used as structural components for all aluminum vehicles and may be recycled with other aluminum alloys used in such vehicles.

Abstract: A method and apparatus for improving the successful transmission of facsimile data over a wireless communication channel is provided comprising a facsimile machine, a wireless transceiver and a connector interfacing therebetween. The facsimile machine detects an interface with the wireless transceiver and notifies the facsimile machine of a wireless communication channel through which facsimile data will traverse. The facsimile machine, in conjunction with the wireless transceiver, establishes a wireless communication channel according to an initial data transfer rate corresponding with the capability of the wireless transceiver or known communication channel conditions. The facsimile machine then exchanges facsimile data over the wireless communication channel and a receiving facsimile machine evaluates the facsimile data to detect errors injected through the wireless communication channel.

Abstract: An implantable orthopedic prosthesis has a macro/micro-textured bone and soft tissue attachment surface to which a spiked washer is clamped by a threaded bolt received through said washer and threaded into said prosthesis. Soft tissue is secured to the prosthesis by clamping between said washer and said soft tissue attachment surface. The tissue attachment surface is arranged as a regular grid of depressions separated by orthogonal ridges formed by electrodischarge machining of the prosthesis using a machining electrode having a mold-opposite surface texture with a micro-textured roughened surface finish. The spacing of the spikes is and integer multiple of the spacing of the depressions to assure registry of the spikes with the depressions.

Abstract: A method of producing an organo-nitrogen compound by the direct conversion of elemental nitrogen, in which a substrate vapor of a simple organic compound, e.g. propanol is mixed with a carrier gas at least partly comprising nitrogen and the vapor mixture is passed over a catalyst, e.g. of a transition metal, and irradiated with microwave radiation to produce a simple organo-nitrogen compound.