Patents by Inventor John Wiencke

John Wiencke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD TO MEASURE MYELOID SUPPRESSOR CELLS FOR DIAGNOSIS AND PROGNOSIS OF CANCER
    Publication number: 20230193400
    Abstract: Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival.
    Type: Application
    Filed: September 30, 2022
    Publication date: June 22, 2023
    Inventors: Karl Kelsey, John Wiencke, Devin Koestler, Brock Christensen
  • Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
    Patent number: 10619211
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: April 14, 2020
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, Jr., Carmen Marsit
  • A METHOD TO MEASURE MYELOID SUPPRESSOR CELLS FOR DIAGNOSIS AND PROGNOSIS OF CANCER
    Publication number: 20190284636
    Abstract: Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 19, 2019
    Applicants: BROWN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF KANSAS, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Karl Kelsey, John Wiencke, Devin Koestler, Brock Christensen
  • Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
    Publication number: 20170067121
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Application
    Filed: September 21, 2016
    Publication date: March 9, 2017
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, JR., Carmen Marsit
  • Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
    Publication number: 20140178348
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 26, 2014
    Applicants: The Regents of the University of California, Brown University
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, JR., Carmen Marsit