Abstract: A method of detecting loss of heterozygosity in HLA alleles is provided. The method can include accessing a trained machine-learning model, which was trained using a training data set that included at least a training data set that includes an adjusted B allele frequency that represents a ratio between a first B allele frequency of heterozygous alleles in the tumor sample that correspond to the genomic region and a second B allele frequency of heterozygous alleles in the genomic region and associated with one or more control samples. The method can also include using the machine-learning model to generate a result corresponding to a probability of whether a loss of heterozygosity exists in an HLA allele identified in the biological sample of the particular subject by processing the sequence data using the machine-learning model.

Abstract: A honeycomb extrusion die comprising at least some slots (308) each with a divot (312) spaced toward a discharge surface (324) from a feedhole-slot intersection (332) and a wide portion at the discharge surface extending into the die body (358) to the divot (312) to strengthen a peripheral region of a honeycomb extrudate in a reinforcement region, and a bulk nominal section corresponding to a bulk region of the honeycomb body.

Abstract: An apparatus and method for a turbine engine having an engine core. A casing can contain a compressor section, a combustor section and a turbine section in axial flow arrangement. An air conduit can extend at least partially between the compressor section and the turbine section. A compliant interface can include a nut and a biasing device mount the air conduit to the casing.

Abstract: A honeycomb extrusion die comprising at least some slots (308) each with a divot (312) spaced toward a discharge surface (324) from a feedhole-slot intersection (332) and a wide portion at the discharge surface extending into the die body (358) to the divot (312) to strengthen a peripheral region of a honeycomb extrudate in a reinforcement region, and a bulk nominal section corresponding to a bulk region of the honeycomb body.

Abstract: An apparatus and method for a turbine engine having an engine core. A casing can contain a compressor section, a combustor section and a turbine section in axial flow arrangement. An air conduit can extend at least partially between the compressor section and the turbine section. A compliant interface can include a nut and a biasing device mount the air conduit to the casing.

Abstract: A nozzle is provided and includes an outer annulus defined by an exterior wall and an interior wall and including air inlets through which air flows to a fuel mixing zone and a combustion zone, an inner annulus disposed within the interior wall and including a fuel volume into which fuel is fed to a distal end thereof, which is adjacent to and isolated from the combustion zone and an airflow line, disposed between the fuel volume and the interior wall, through which air flows to the combustion zone with the airflow line and the combustion zone isolated from the fuel volume, and a fuse configured to melt during a flameholding incident and to form a breach through which fuel flows from the fuel volume, bypassing the fuel mixing zone, to a fuel burning zone downstream from the fuel mixing zone.

Abstract: A nozzle is provided and includes an outer annulus defined by an exterior wall and an interior wall and including air inlets through which air flows to a fuel mixing zone and a combustion zone, an inner annulus disposed within the interior wall and including a fuel volume into which fuel is fed to a distal end thereof, which is adjacent to and isolated from the combustion zone and an airflow line, disposed between the fuel volume and the interior wall, through which air flows to the combustion zone with the airflow line and the combustion zone isolated from the fuel volume, and a fuse configured to melt during a flameholding incident and to form a breach through which fuel flows from the fuel volume, bypassing the fuel mixing zone, to a fuel burning zone downstream from the fuel mixing zone.

Abstract: A highly conductive thermoplastic elastomer gap filler having superior durability and EMI shielding properties. According to the preferred embodiment, the TPE comprises graphite fiber having a nickel-copper-nickel coating formed thereabout that is suspended within an elastomer, which preferably comprises polyvinylchloride. The TPE of the present invention is particularly well-suited for reducing radio frequency electromagnetic radiation reflected by gaps formed between adjacent panels of a structure, and is particularly well-suited for the maintenance and repair of low observable aircraft. The TPE of the present invention may further be modified to include carbon black filler.

Abstract: A configuration of a thyristor stack is provided. The stack includes thyristors, electrically conductive bars, and reactors that are mounted around the electrically conductive. Heat sinks may be included in the thyristor stack to assist in heat dissipation, although they may not be necessary. A method for constructing a thyristor stack is also provided.

Abstract: A configuration of a thyristor stack is provided. The stack comprises thyristors, electrically conductive bars, and reactors that are mounted around the electrically conductive. Heat sinks may be included in the thyristor stack to assist in heat dissipation, although they may not be necessary. A method for constructing a thyristor stack is also provided.

Abstract: Highly conductive elastomeric sheet. Preferably, the conductive elastomeric sheet comprises a conductive wire mesh loaded into an elastomeric matrix from which is also loaded with a conductive particulate. Preferably, the particulate comprises carbon particulate having a sub-micron size, and is present in an amount between ten percent (10%) to twenty percent (20%) by volume. The conductive elastomeric materials are exceptionally durable and retain a high degree of conductivity well-after ten thousand (10,000) fatigue performance cycles.

Abstract: A highly conductive thermoplastic elastomer (TPE) gap filler having superior durability and EMI shielding properties. According to the preferred embodiment, the TPE comprises graphite fiber having a nickel-copper-nickel coating formed thereabout that is suspended within an elastomer, which preferably comprises polyvinylchloride (PVC). The TPE of the present invention is particularly well-suited for reducing radio frequency electromagnetic radiation reflected by gaps formed between adjacent panels of a structure, and is particularly well-suited for the maintenance and repair of LO aircraft. The TPE of the present invention may further be modified to include carbon black filler.

Abstract: A system for transmitting power and motion is presented in which at least one component for transmitting power and motion communicates power and motion to another component in which two means are articles of polyketone polymer. In one aspect of the invention the component for transmitting power and motion are spur gears. In another aspect of the invention at least one of the component for transmitting power and motion includes worm gearing.

Abstract: A method of improving the tribological properties of a polyketone polymer are presented in which polyketone polymer starting materials are blended with an aramide. Blends produced according to this process are also presented. The blend is particularly useful in the manufacture of articles used in applications where surfaces are in contact during motion.