Abstract: Databases methods and reagents are disclosed for the generation of large amounts of biomarker data from readily obtained sample such as dried plasma spots, and for uses of such databases in the development of patient categorization or detection of changes in a patient's health status over time.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, in which distal ends of the clip arms extend distally past the distal end of the capsule to be separated from one another, and a closed configuration, in which the clip arms are restrained via an interior surface of the capsule so that distal ends of the clips arms are drawn toward one another, and a reinforcement element coupled to the clip arms, the reinforcement element preventing deflection of the clip arms when engaging a target tissue.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, in which distal ends of the clip arms extend distally past the distal end of the capsule to be separated from one another, and a closed configuration, in which the clip arms are restrained via an interior surface of the capsule so that distal ends of the clips arms are drawn toward one another, and a reinforcement element coupled to the clip arms, the reinforcement element preventing deflection of the clip arms when engaging a target tissue.

Abstract: An ion filtration air cleaning device for cleaning air by use of electrostatic ion attraction. Air having suspended particles is drawn into the device through an inlet by a fan. An ionization source near the inlet generates ions. Electrical charge transfers from the ions to the suspended particles. The fan pushes the air and suspended charged particles toward an outlet.

Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.

Abstract: Space interaction (SI) functionality is described herein for assisting a user in interacting with a space without unduly distracting the user. The SI functionality includes an application interface module that presents information and/or exposes functionality within a plurality of workspaces. Each workspace has a determined spatial relationship with respect to other workspaces. Further, the application interface module may detect and respond to various gestures, by which the user may move among workspaces and interact with menus and other information that are presented in those workspaces. The user's interaction with these workspaces and menus may be supplemented by various sounds generated by a sound generation module, and/or various haptic cues (e.g., vibration cues) generated by a haptic cue generation module.

Abstract: A method for filtering air includes: passing air through a prefilter disposed in a housing to remove at least a portion of particulates suspended in the air to thereby create prefiltered air; passing the prefiltered air by an ionizer disposed in the housing to ionize at least a portion of the particulates suspended in the air to thereby create ionized particulates in the prefiltered air, the ionizer downstream from the prefilter and upstream from the fan positioned to create an airflow within the housing; and prior to the prefiltered air exiting the housing with ionized particulates, causing the ionized particulates to pass through an electrostatically charged main filter disposed within the housing downstream from each of the ionizer and the fan.

Abstract: A headset is described herein for presenting audio information to the user as the user interacts with a space, e.g., as when a user navigates over a route within a space. The headset may include a set of input mechanisms for receiving commands from the user. The commands, in turn, invoke respective space-interaction-related functions to be performed by a space interaction (SI) module. The headset may operate with or without a separate user computing device.

Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.

Abstract: A device for causing hemostasis includes a sheet of mesh stretchable between an expanded and a retracted configuration, a size of the sheet in the retracted configuration being selected to cover a target tissue site; a spring mechanism coupled to the mesh, the spring mechanism moving between an expanded configuration and a retracted configuration when the mesh is moved between the expanded and retracted configurations; and a plurality of hooks coupled to the mesh and oriented to extend into tissue to lock the mesh in position when the mesh is placed in a desired position over the target tissue site in the expanded configuration. The hooks are lockingly engaging the target tissue so that, after the hooks have lockingly engaged the tissue, the spring mechanism reverts to the retracted configuration drawing the engaged portions of tissue radially inward.

Abstract: A cooking appliance includes a cooktop and a grate. The cooktop includes a bottom surface on which at least one gas burner is mounted. The cooktop further includes a periphery and an inner recessed area. The inner recessed area is recessed relative to the periphery. The inner recessed area is substantially defined by the bottom surface. The cooktop further includes a transition extending between the periphery and the inner recessed area and a sweep section extending between the periphery and the inner recessed area. The inner recessed area is surrounded substantially by the transition except at the sweep section. The grate is configured to be placed on the cooktop. Each of the sweep section and the transition extends between the bottom surface and a predetermined elevation above the bottom surface. The sweep section reaches the predetermined elevation in a more gradual manner than the transition reaches the predetermined elevation.

Abstract: A method for filtering air includes: passing air through a prefilter disposed in a housing to remove at least a portion of particulates suspended in the air to thereby create prefiltered air; passing the prefiltered air by an ionizer disposed in the housing to ionize at least a portion of the particulates suspended in the air to thereby create ionized particulates in the prefiltered air, the ionizer downstream from the prefilter and upstream from the fan positioned to create an airflow within the housing; and prior to the prefiltered air exiting the housing with ionized particulates, causing the ionized particulates to pass through an electrostatically charged main filter disposed within the housing downstream from each of the ionizer and the fan.

Abstract: An ion filtration air cleaning device for cleaning air by use of electrostatic ion attraction. Air having suspended particles is drawn into the device through an inlet by a fan. An ionization source near the inlet generates ions. Electrical charge transfers from the ions to the suspended particles. The fan pushes the air and suspended charged particles toward an outlet. A filter located adjacent to the outlet operates by electrostatic attraction and filters the charged particles from the air, allowing cleansed air to be released from the device, with a reduced level of charged particle emission.