Patents by Inventor John Wing Wong

John Wing Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
    Patent number: 8304252
    Abstract: The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: November 6, 2012
    Assignee: Pfizer Inc.
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • Stereoselective Bioconversion of Aliphatic Dinitriles into Cyano Carboxylic Acids
    Publication number: 20100204503
    Abstract: The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Application
    Filed: April 20, 2010
    Publication date: August 12, 2010
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
    Patent number: 7727749
    Abstract: The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: June 1, 2010
    Assignee: Pfizer, Inc.
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • PROCESS FOR THE SYNTHESIS OF CIS-1,3-DIOLS
    Publication number: 20080118962
    Abstract: A process for selectively reducing beta-hydroxy ketones, using a ketone reductase obtained from: Monosporium, Rhodococcus, Lechevalieria, Fusarium, Sporidiobolus, Streptomyces, Absidia, or Rhodotorula, to obtain the corresponding cis-1,3-diol. A purified ketone reductase obtained from an organism of the genera Monosporium, Rhodococcus, Lechevalieria, Fusarium, Sporidiobolus, Streptomyces, Absidia, or Rhodotorula.
    Type: Application
    Filed: November 16, 2007
    Publication date: May 22, 2008
    Inventors: Michael Paul Burns, John Wing Wong