Patents by Inventor John Woodcraft

John Woodcraft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Automated radiosynthesis
    Patent number: 8946410
    Abstract: The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: February 3, 2015
    Assignee: GE Healthcare Limited
    Inventors: John Woodcraft, L Clare Jones, Alessandra Gaeta, John William Trigg, Alexander Paul Jones, Stuart Plant, Alexander Jackson
  • Fluoridation of iodonium salts
    Patent number: 8466313
    Abstract: The present invention provides an improved method for fluoridation of an iodonium salt wherein a solution of the iodonium salt comprising a free radical trap is stored before the reaction is carried out. The method of the invention may be automated, which is particularly convenient when the method of the invention is radiofluoridation. As such the present invention also provides a cassette comprising the iodonium salt solution suitable for carrying out the method of the invention on an automated synthesizer.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: June 18, 2013
    Assignee: GE Healthcare Limited
    Inventor: John Woodcraft
  • AUTOMATED RADIOSYNTHESIS
    Publication number: 20120190843
    Abstract: The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.
    Type: Application
    Filed: October 8, 2010
    Publication date: July 26, 2012
    Inventors: John Woodcraft, L. Clare Jones, Alessandra Gaeta, John William Trigg, Alexander Paul Jones, Stuart Plant, Alexander Jackson
  • [18F] LABELLED ANALOGUES OF FLUMAZENIL AS IN VIVO IMAGING AGENTS
    Publication number: 20120189547
    Abstract: The present invention provides radiofluorinated compounds useful for in vivo imaging GABAA receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.
    Type: Application
    Filed: October 8, 2010
    Publication date: July 26, 2012
    Inventors: John Woodcraft, Clare L. Jones, Alessandra Gaeta, William John Trigg, Paul Alexander Jones, Stuart Plant
  • FLUORIDATION OF IODONIUM SALTS
    Publication number: 20110144344
    Abstract: The present invention provides an improved method for fluoridation of an iodonium salt wherein a solution of the iodonium salt comprising a free radical trap is stored before the reaction is carried out. The method of the invention may be automated, which is particularly convenient when the method of the invention is radiofluoridation. As such the present invention also provides a cassette comprising the iodonium salt solution suitable for carrying out the method of the invention on an automated synthesizer.
    Type: Application
    Filed: August 13, 2009
    Publication date: June 16, 2011
    Inventor: John Woodcraft
  • IMAGING THE CENTRAL NERVOUS SYSTEM
    Publication number: 20110027178
    Abstract: The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.
    Type: Application
    Filed: February 26, 2009
    Publication date: February 3, 2011
    Inventors: Paul Alexander Jones, Ian Wilson, Veronique Morrison-Iveson, Clare Jones, John Woodcraft, Alex Jackson, Duncan Wynn