Abstract: Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for using JavaScript Object Notation (JSON) Web Tokens for information security for a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of client-provided information, hardware information, key information, and permission information; provide individual JWTs that include individual expiration dates to individual users; receive a user request for continued access and/or use of the particular software-controlled application; perform different types of (automated) verification based on the client-provided information in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and accepting or denying continued access and/or use of the particular software-controlled application.

Abstract: Systems and methods for using JavaScript Object Notation (JSON) Web Tokens for information security for a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of client-provided information, hardware information, key information, and permission information; provide individual JWTs that include individual expiration dates to individual users; receive a user request for continued access and/or use of the particular software-controlled application; perform different types of (automated) verification based on the client-provided information in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and accepting or denying continued access and/or use of the particular software-controlled application.

Abstract: Aspects of the disclosure relate to a production protection correlation engine. In some embodiments, a computing platform may acquire access permission data aggregated from a plurality of data sources and normalize the access permission data. Then, the computing platform may identify user-specific entitlements and classify user roles. Next, the computing platform may tag the normalized permission data based on user role classification data. Based on the tagging, the computing platform may identify at least one enterprise user having one or more toxic access permissions and, in response, trigger an access review process. In turn, the computing platform may revoke one or more incompatible access permissions. Then, the computing platform may transmit updated access permission data to a system of record, causing the system of record to store the updated access permission data in a database and limit access to enterprise resources based on the updated access permission data.

Abstract: Systems and methods for facilitating asynchronous secured point-to-point communications between a first user and a second user are disclosed. Particularly, the communications do not require centralized storage. Exemplary implementations may: store information electronically, including different types of client-specific information, hardware information, key information, and permission information; receive a communication request from a first user; transfer a response to the communication request; receive a status check request from the second user; transfer a response to the status check request; receive a transfer request from the second user; transfer a response to the transfer request; receive a status request from the first user; and transfer a response to the status request.

Abstract: Systems and methods for using JavaScript Object Notation (JSON) Web Tokens for information security for a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of client-provided information, hardware information, key information, and permission information; provide individual JWTs that include individual expiration dates to individual users; receive a user request for continued access and/or use of the particular software-controlled application; perform different types of (automated) verification based on the client-provided information in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and accepting or denying continued access and/or use of the particular software-controlled application.

Abstract: Systems and methods for providing authentication and authorization for software license management of a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of user information, hardware information, key information, and license information; receive a user request for user-specific authentication and device-specific authorization to access and/or use the particular software-controlled application; perform different types of (automated) verification based on the user identifier, the hardware identifier, and the machine identifier in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and performing registration and/or assignment as requested.

Abstract: Systems and methods for using JavaScript Object Notation (JSON) Web Tokens for information security for a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of client-provided information, hardware information, key information, and permission information; provide individual JWTs that include individual expiration dates to individual users; receive a user request for continued access and/or use of the particular software-controlled application; perform different types of (automated) verification based on the client-provided information in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and accepting or denying continued access and/or use of the particular software-controlled application.

Abstract: Systems and methods for providing authentication and authorization for software license management of a particular software-controlled application are disclosed. Exemplary implementations may: store information electronically, including different types of user information, hardware information, key information, and license information; receive a user request for user-specific authentication and device-specific authorization to access and/or use the particular software-controlled application; perform different types of (automated) verification based on the user identifier, the hardware identifier, and the machine identifier in the user request; and, responsive to particular results from the different types of verification, perform some combination of transferring a response to the user request and performing registration and/or assignment as requested.

Abstract: Systems and methods for facilitating asynchronous secured point-to-point communications between a first user and a second user are disclosed. Particularly, the communications do not require centralized storage. Exemplary implementations may: store information electronically, including different types of client-specific information, hardware information, key information, and permission information; receive a communication request from a first user; transfer a response to the communication request; receive a status check request from the second user; transfer a response to the status check request; receive a transfer request from the second user; transfer a response to the transfer request; receive a status request from the first user; and transfer a response to the status request.

Abstract: Aspects of the disclosure relate to a production protection correlation engine. In some embodiments, a computing platform may acquire access permission data aggregated from a plurality of data sources and normalize the access permission data. Then, the computing platform may identify user-specific entitlements and classify user roles. Next, the computing platform may tag the normalized permission data based on user role classification data. Based on the tagging, the computing platform may identify at least one enterprise user having one or more toxic access permissions and, in response, trigger an access review process. In turn, the computing platform may revoke one or more incompatible access permissions. Then, the computing platform may transmit updated access permission data to a system of record, causing the system of record to store the updated access permission data in a database and limit access to enterprise resources based on the updated access permission data.

Abstract: A butterfly valve comprising a valve body and a rotatable obturator (3), the rotatable obturator mounted in the valve body for rotation about an axis, arranged to be rotated between a closed condition and an open condition, the rotatable obturator comprising an actuated seal (5) which is arranged to seal against a sealing surface (12a) of the valve body, and the actuated seal comprising a rearward surface (5e) arranged to be acted on by a pressurised fluid, and the seal mounted in the obturator for displacement outwardly from the obturator as the result of application of the pressurised fluid so as to seal against the sealing surface of the valve body in a substantially fluid-tight manner.

Abstract: A method of manufacturing a directionally solidified article of the present disclosure includes providing a collection of particulate material and additively manufacturing a first article with an outer wall from the particulate material. The outer wall defines at least part of a cavity. The cavity contains an amount of the particulate material. The method also includes encasing at least a portion of the first article with an outer member. The outer member defines an internal cavity that corresponds to the first article. The method further includes heating the outer member and the first article to melt the first article into a molten mass within the internal cavity of the outer member. Additionally, the method includes solidifying the molten mass along a predetermined solidification path within the outer member to form a second article that corresponds to at least a portion of the internal cavity of the outer member.

Abstract: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Charcoal Rot Drought Complex. The methods use molecular genetic markers to identify, select and/or construct tolerant plants or identify and counter-select susceptible plants. Soybean plants that display tolerance or improved tolerance to Charcoal Rot Drought Complex that are generated by the methods of the invention are also a feature of the invention. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A method of manufacturing a directionally solidified article of the present disclosure includes providing a collection of particulate material and additively manufacturing a first article with an outer wall from the particulate material. The outer wall defines at least part of a cavity. The cavity contains an amount of the particulate material. The method also includes encasing at least a portion of the first article with an outer member. The outer member defines an internal cavity that corresponds to the first article. The method further includes heating the outer member and the first article to melt the first article into a molten mass within the internal cavity of the outer member. Additionally, the method includes solidifying the molten mass along a predetermined solidification path within the outer member to form a second article that corresponds to at least a portion of the internal cavity of the outer member.

Abstract: A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immunostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizing groups to the arylrings that include phosphonyl groups.

Abstract: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Charcoal Rot Drought Complex. The methods use molecular genetic markers to identify, select and/or construct tolerant plants or identify and counter-select susceptible plants. Soybean plants that display tolerance or improved tolerance to Charcoal Rot Drought Complex that are generated by the methods of the invention are also a feature of the invention. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Charcoal Rot Drought Complex. The methods use molecular genetic markers to identify, select and/or construct tolerant plants or identify and counter-select susceptible plants. Soybean plants that display tolerance or improved tolerance to Charcoal Rot Drought Complex that are generated by the methods of the invention are also a feature of the invention. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A process for casting a turbine wheel includes steps of identifying a metal composition from which the turbine wheel is to be cast, providing a mold that defines a cavity into which molten metal composition is to be poured for casting the wheel, providing a seed member made of the metal composition and having an equiaxed grain structure, disposing at least a portion of the seed member within the cavity of the mold, pouring the molten metal composition into the cavity such that the molten metal composition envelops the portion of the seed member within the cavity, and controlling the process so that the portion of the seed member at least partially melts through contact with the molten metal composition and so that, upon cooling, the metal composition around the seed member solidifies with an equiaxed grain structure as precipitated by the equiaxed grain structure of the seed member.

Abstract: A chip card interface device (CCID) is configured for protecting data stored at the CCID in the event of a compromise. The CCID has a housing and a compromise detection system including one or more detection devices configured for detecting a compromise of the housing. The compromise detection system is configured for generating a detection signal indicating the detected compromise. A data protection system is coupled with the compromise detection system and includes a memory device and a processing device coupled with the compromise detection system. The processing device is for receiving the detection signal and erasing data stored on the memory device based on the detection signal in some embodiments. In some embodiments, the processing device also activates a locking function for rendering itself inoperable based on the detection signal.