Abstract: This invention provides a method for obtaining a recombinant antibody with a desired function, comprising: (a) providing a population of anti-body-forming cells suspected of containing at least one cell capable of producing an antibody exhibiting the desired function; (b) generating one or more transcriptionally active recombinant linear polynucleotides from the antibody-forming cells obtained in step (a) wherein each transcriptionally active recombinant linear polynucleotide comprises a polynucleotide sequence encoding a variable domain of an antibody produced by an antibody-forming cell obtained in step (a) and one or more transcription regulatory elements; (c) expressing a recombinant antibody using one or more of the transcriptionally active recombinant linear polynucleotides generated in step (b); (d) screening the recombinant antibody produced by step (c) for the desired function; and (e) optionally repeating steps (b), (c) and (d) to identify a recombinant antibody exhibiting the desired function.

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.

Abstract: Various embodiments of a neural monitoring device and related methods are disclosed herein. An exemplary neural monitoring device can be used during various surgical procedures to assess neural activity, status, health, etc. in order to anticipate and prevent nerve damage due to neural ischemia and other neural conditions. In some embodiments, a neural monitoring device can be configured to monitor neural activity, status, health, etc. of nerves encountered during a spinal surgical procedure. Embodiments of the neural monitoring device can also be used in non-spinal surgical procedures that can risk neural damage.

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of (A-X)2:(Y-B)2) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

Abstract: A system (100) for handling sheets of flexible material comprises: a plurality of releasable connectors (20) supported on a main carrier (110). The releasable connectors (20) are individually addressable so that when actuated a connector lifts or releases a sheet of flexible material. One or more end adjustment means is provided to vary at least one of: the orientation and/or the location of the connectors (20), with respect to a surface defined in three dimensions, such that in use the sheet of flexible material is placed in a precise user selected position on the three dimensional surface without the material creasing or wrinkling. An advantage of the present invention is that previously actuators were able to orient grippers to be normal to the surface of a cylinder; whereas the provision of parallel, flexible strips enables active surfaces to be positioned normal to the surface of complex surface, such as that defined by a cone.

Abstract: Mechanisms for interferer detection can detect interferers by detecting elevated signal amplitudes in one or more of a plurality of bins (or bands) in a frequency range between a maximum frequency (fMAX) and a minimum frequency (fMIN). To perform rapid interferer detection, the mechanisms downconvert an input signal x(t) with a local oscillator (LO) to a complex baseband signal xI(t)+jxQ(t). xI(t) and xQ(t) are then multiplied by m unique pseudorandom noise (PN) sequences (e.g., Gold sequences) gm(t) to produce m branch signals for I and m branch signals for Q. The branch signals are then low pass filtered, converted from analog to digital form, and pairwise combined by a pairwise complex combiner. Finally, a support recovery function is used to identify interferers.

Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

Abstract: The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.

Abstract: Mechanisms for interferer detection can detect interferers by detecting elevated signal amplitudes in one or more of a plurality of bins (or bands) in a frequency range between a maximum frequency (fMAX) and a minimum frequency (fMIN). To perform rapid interferer detection, the mechanisms downconvert an input signal x(t) with a local oscillator (LO) to a complex baseband signal xI(t)+jxQ(t). xI(t) and xQ(t) are then multiplied by m unique pseudorandom noise (PN) sequences (e.g., Gold sequences) gm(t) to produce m branch signals for I and m branch signals for Q. The branch signals are then low pass filtered, converted from analog to digital form, and pairwise combined by a pairwise complex combiner. Finally, a support recovery function is used to identify interferers.

Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD79, said binding domain comprising SEQ ID NO: 1, 2, 3 or 4, and/or SEQ ID NO: 5, 6 and 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Abstract: Connectors for connecting or linking one instrument or object to one or more other instruments or objects are disclosed herein. In some embodiments, a connector can include a first arm with a first attachment feature for attaching to a first object, such as a surgical access device, and a second arm with a second attachment feature for attaching to a second object, such as a support. The connector can have an unlocked state, in which the position and orientation of the access device can be adjusted relative to the support, and a locked state in which movement of the access device relative to the support is prevented or limited. Locking the connector can also be effective to clamp or otherwise attach the connector to the access device and the support, or said attachment can be independent of the locking of the connector.

Abstract: A computing device may receive authentication information. Within a time-out period, a fingerprint may also be received. The computing device may assign one or more authentication credentials to the fingerprint based on authentication credentials associated with the received authentication information. In some implementations, the computing device may assign the authentication credentials associated with the received authentication information to the biometric. However, in other implementations, the computing device may assign different authentication credentials to the biometric based on one or more user preferences, defaults, security policies, and/or enterprise policies. In various implementations, the authentication credentials assigned to the biometric may be altered, such as by adding and/or removing one or more authentication credentials. Such alteration may be performed in response to a received user request, changed enterprise policy, changed security policy, fraud alert, and/or other such factor.

Abstract: A method of actuating an extinguisher system may comprise retaining a broadhead cutter in close proximity to a burst disc surface, receiving an impulse signal, actuating a spring release mechanism in response to receiving the impulse signal, driving a cutter shaft towards the burst disc surface in response to actuation, and piercing the burst disc surface via the broadhead cutter coupled to the cutter shaft.

Abstract: Systems, methods, and devices for managing predetermined functions on a mobile device, the operating system (OS) installed on the device including an event application programming interface (API) configured to enable voice over internet protocol (VoIP) applications to assume priority over other applications and functions of the mobile device when VoIP calls are detected. A mobile device management software application installed and running on the mobile device emulates a VoIP software application and uses event API calls to trick the OS into believing that a VoIP call has been detected and, in response, causes the OS to block or interfere with one or more predetermined functions on the mobile device based on the status and location of the mobile device.

Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Abstract: A computing device may determine to capture biometric information in response to the occurrence of one or more trigger conditions. The trigger condition may be receipt of one or more instructions from one or more other computing devices, detection of potential unauthorized use by the computing device, normal operation of the computing device, and so on. The computing device may obtain biometric information and may store such biometric information. Such biometric information may be one or more fingerprints, one or more images of a current user of the computing device, video of the current user, audio of the environment of the computing device, forensic interface use information, and so on. The computing device may then provide the stored biometric information for identification of one or more unauthorized users.

Abstract: The present disclosure relates to a broadhead cutter activation mechanism and system inside of a fire extinguisher. The broadhead cutter device may be attached to a cutter shaft which is driven downward when the elastic potential energy is released form a spring system. The broadhead cutter device may be configured to pierce and open a burst disc to release the flow of an extinguishing agent under pressure.

Abstract: A computing device may receive authentication information. Within a time-out period, a fingerprint may also be received. The computing device may assign one or more authentication credentials to the fingerprint based on authentication credentials associated with the received authentication information. In some implementations, the computing device may assign the authentication credentials associated with the received authentication information to the biometric. However, in other implementations, the computing device may assign different authentication credentials to the biometric based on one or more user preferences, defaults, security policies, and/or enterprise policies. In various implementations, the authentication credentials assigned to the biometric may be altered, such as by adding and/or removing one or more authentication credentials. Such alteration may be performed in response to a received user request, changed enterprise policy, changed security policy, fraud alert, and/or other such factor.