Patents by Inventor John Wyrick

John Wyrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome wide location and function of DNA binding proteins
    Patent number: 7575869
    Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: August 18, 2009
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: John Wyrick, Richard A. Young, Bing Ren, Robert Francois, Itamar Simon
  • Genome-wide location and function of DNA binding proteins
    Patent number: 7470507
    Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: December 30, 2008
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: John Wyrick, Richard A. Young, Bing Ren, Francois Robert, Itamar Simon
  • GENOME-WIDE LOCATION AND FUNCTION OF DNA BINDING PROTEINS
    Publication number: 20080241822
    Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
    Type: Application
    Filed: December 21, 2001
    Publication date: October 2, 2008
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: John Wyrick, Richard A. Young, Bing Ren, Francois Robert, Itamar Simon
  • Genome wide location and function of DNA binding proteins
    Publication number: 20080125328
    Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 29, 2008
    Inventors: John Wyrick, Richard Young, Bing Ren, Francois Robert, Itamar Simon
  • Chromosome-wide analysis of protein-DNA interactions
    Patent number: 6410243
    Abstract: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: June 25, 2002
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: John Wyrick, Richard A. Young, Bing Ren, Francois Robert