Abstract: Embodiments of the present invention relate to elimination of blocks such as splits in distributed processing systems such as MapReduce systems using the Hadoop Distributed Filing System (HDFS). In one embodiment, a method of and computer program product for optimizing queries in distributed processing systems are provided. A query is received. The query includes at least one predicate. The query refers to data. The data includes a plurality of records. Each record comprises a plurality of values in a plurality of attributes. Each record is located in at least one of a plurality of blocks of a distributed file system. Each block has a unique identifier. For each block of the distributed file system, at least one value cluster is determined for an attribute of the plurality of attributes. Each value cluster has a range. The predicate of the query is compared with the at least one value cluster of each block.

Abstract: Embodiments of the present invention relate to elimination of blocks such as splits in distributed processing systems such as MapReduce systems using the Hadoop Distributed Filing System (HDFS). In one embodiment, a method of and computer program product for optimizing queries in distributed processing systems are provided. A query is received. The query includes at least one predicate. The query refers to data. The data includes a plurality of records. Each record comprises a plurality of values in a plurality of attributes. Each record is located in at least one of a plurality of blocks of a distributed file system. Each block has a unique identifier. For each block of the distributed file system, at least one value cluster is determined for an attribute of the plurality of attributes. Each value cluster has a range. The predicate of the query is compared with the at least one value cluster of each block.

Abstract: Embodiments of the present invention relate to elimination of blocks such as splits in distributed processing systems such as MapReduce systems using the Hadoop Distributed Filing System (HDFS). In one embodiment, a method of and computer program product for optimizing queries in distributed processing systems are provided. A query is received. The query includes at least one predicate. The query refers to data. The data includes a plurality of records. Each record comprises a plurality of values in a plurality of attributes. Each record is located in at least one of a plurality of blocks of a distributed file system. Each block has a unique identifier. For each block of the distributed file system, at least one value cluster is determined for an attribute of the plurality of attributes. Each value cluster has a range. The predicate of the query is compared with the at least one value cluster of each block.

Abstract: Embodiments of the present invention relate to elimination of blocks such as splits in distributed processing systems such as MapReduce systems using the Hadoop Distributed Filing System (HDFS). In one embodiment, a method of and computer program product for optimizing queries in distributed processing systems are provided. A query is received. The query includes at least one predicate. The query refers to data. The data includes a plurality of records. Each record comprises a plurality of values in a plurality of attributes. Each record is located in at least one of a plurality of blocks of a distributed file system. Each block has a unique identifier. For each block of the distributed file system, at least one value cluster is determined for an attribute of the plurality of attributes. Each value cluster has a range. The predicate of the query is compared with the at least one value cluster of each block.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

Abstract: A method of processing a pressure image, the method comprising: receiving a plurality of first continuous pressure images; processing each of said first continuous pressure images to generate a respective second continuous pressure image; and generating a continuous statistical image representing a characteristic of the first pressure images by processing said second continuous pressure images.

Abstract: Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

Abstract: RNA interference is provided for inhibition of tumor necrosis factor ? (TNF?) by silencing TNF? cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNF? converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNF? targets, in particular, is useful for treating patients having a TNF?-related condition or at risk of developing a TNF?-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.

Abstract: The present invention provides compositions comprising the 15-lipoxygenase-1 (15-LO-1) or 15-lipoxyngenase-2 (15-LO-2) gene such that 15-LO-1 or 15-LO-2 protein expression is replaced or replenished in the ocular surface epithelium of post-menopausal women suffering from dry eye. Thus, methods for treatment of dry eye in postmenopausal women are further provided.

Abstract: The topical use of 13(S)-HODE and analogs are disclosed for the treatment of dry eye disorders.

Abstract: Methods of treating dry eye by administering fixed combinations of MUC-1 secretagogues, such as HETE derivatives, and anti-inflammatory steroids are disclosed.

Abstract: Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

Abstract: The use of amfenac and derivatives, including nepafenac, to treat vascular endothelial growth factor mediated vascular disorders.