Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: A personal safety system, including: a mobile telephone device; and a personal safety device, including: a sensor, a transceiver module configured to send, in response to activation of the sensor by a user, an activation signal to the mobile telephone device via a wireless link, and an indicator configured to indicate to the user: a device state of the personal safety device, including an activated state corresponding to the activation of the sensor; and reception of an incoming call or message by the mobile telephone device, wherein: the mobile telephone device is configured to generate an alert signal based on the activation signal, and to send the alert signal to a recipient based on alerting configuration data representing the recipient pre-selected by the user; the alert signal represents user location data representing a location of the mobile telephone device; and the sensor includes a proximity sensor which is activated by the personal safety device being out of communication range of the mobile telep

Abstract: A method of controlling the speed of a right front wheel and a left front wheel on a work machine includes receiving a speed command based at least partially on an operator input and monitoring at least one wheel steering angle of at least one front wheel. A first front wheel speed command may be determined based at least partially on the at least one wheel steering angle. In addition, a second front wheel speed command may be determined based at least partially on the at least one wheel steering angle. The first front wheel speed command and the second front wheel speed command may be output to independently control the speed of the right and the left front wheels.

Abstract: A system for mitigating hop in a propelled machine is provided. A controller is operable to receive an aggressiveness command based on an operator input. A sensor is operable to measure a parameter indicative of hop and output a hop signal indicative of a magnitude of machine hop, based on the measurement. A manager is operable to reduce an aggressiveness indicated by the aggressiveness command in proportion to the indicated magnitude of machine hop.

Abstract: A method is provided for controlling an all-wheel-drive vehicle. The method includes providing an aggression signal and determining a desired speed ratio based on the aggression signal. An output speed signal corresponding to the determined desired speed ratio is generated.

Abstract: A method of controlling the speed of a right front wheel and a left front wheel on a work machine includes receiving a speed command based at least partially on an operator input and monitoring at least one wheel steering angle of at least one front wheel. A first front wheel speed command may be determined based at least partially on the at least one wheel steering angle. In addition, a second front wheel speed command may be determined based at least partially on the at least one wheel steering angle. The first front wheel speed command and the second front wheel speed command may be output to independently control the speed of the right and the left front wheels.

Abstract: A method for controllably moving a machinery platform 20 of a work machine 10 having an electro-hydraulic system 100 is disclosed. The work machine 10 includes at least one swing motor 120 configured to move the machinery platform 20. The changing speed of the swing motor 120 is determined. A solenoid actuated valve 165 is controlled in response to the determination. The solenoid actuated valve 165 is configured to responsively produce a relief valve pilot signal 170. The two-way relief valve 130 is controllably shifted in response to the inputted relief valve pilot signal 170. At least one of a high pressure by-pass valve 135 and a low pressure by-pass valve 140 is selected in response to the two-way relief valve 130 shifting.