Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6.

Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6.

Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6, such as e.g. cancer and inflammatory conditions. Preferred compounds are 6-oxodecahydropyrrolo[1,2-a][1,5]diazocine and 6-oxodecahydro-4H-pyrrolo[2,1-d][1,5]thiazocine derivatives.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: A personal safety system, including: a mobile telephone device; and a personal safety device, including: a sensor, a transceiver module configured to send, in response to activation of the sensor by a user, an activation signal to the mobile telephone device via a wireless link, and an indicator configured to indicate to the user: a device state of the personal safety device, including an activated state corresponding to the activation of the sensor; and reception of an incoming call or message by the mobile telephone device, wherein: the mobile telephone device is configured to generate an alert signal based on the activation signal, and to send the alert signal to a recipient based on alerting configuration data representing the recipient pre-selected by the user; the alert signal represents user location data representing a location of the mobile telephone device; and the sensor includes a proximity sensor which is activated by the personal safety device being out of communication range of the mobile telep

Abstract: A method of controlling the speed of a right front wheel and a left front wheel on a work machine includes receiving a speed command based at least partially on an operator input and monitoring at least one wheel steering angle of at least one front wheel. A first front wheel speed command may be determined based at least partially on the at least one wheel steering angle. In addition, a second front wheel speed command may be determined based at least partially on the at least one wheel steering angle. The first front wheel speed command and the second front wheel speed command may be output to independently control the speed of the right and the left front wheels.

Abstract: A system for mitigating hop in a propelled machine is provided. A controller is operable to receive an aggressiveness command based on an operator input. A sensor is operable to measure a parameter indicative of hop and output a hop signal indicative of a magnitude of machine hop, based on the measurement. A manager is operable to reduce an aggressiveness indicated by the aggressiveness command in proportion to the indicated magnitude of machine hop.

Abstract: A method is provided for controlling an all-wheel-drive vehicle. The method includes providing an aggression signal and determining a desired speed ratio based on the aggression signal. An output speed signal corresponding to the determined desired speed ratio is generated.

Abstract: A method of controlling the speed of a right front wheel and a left front wheel on a work machine includes receiving a speed command based at least partially on an operator input and monitoring at least one wheel steering angle of at least one front wheel. A first front wheel speed command may be determined based at least partially on the at least one wheel steering angle. In addition, a second front wheel speed command may be determined based at least partially on the at least one wheel steering angle. The first front wheel speed command and the second front wheel speed command may be output to independently control the speed of the right and the left front wheels.