Patents by Inventor John Young Ling Chiang

John Young Ling Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genomic DNA of human cholesterol 7.alpha.-hydroxylase and methods for using it
    Patent number: 5851780
    Abstract: Genomic DNA of cholesterol 7.alpha.-hydroxylase and a minigene are disclosed. The minigene is used for making a transgenic animal that produces functionally active cholesterol 7.alpha.-hydroxylase and functions as a disease model. A cholesterol 7.alpha.-hydroxylase promoter region and reporter gene construct is provided, as well as a transgenic animal that expresses the promoter/reporter gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 22, 1998
    Assignee: Northeastern Ohio University
    Inventor: John Young Ling Chiang
  • Cholesterol 7 .alpha.-hydroxdylase gene regulatory elements and transcription factors
    Patent number: 5753431
    Abstract: DNA regulatory elements that control cholesterol 7.alpha.-hydroxylase expression are disclosed, including bile acid responsive elements. A gene construct comprising at least one CYP7 regulatory element and a reporter gene is used to transfect HepG2 cells. Confluent transfected HepG2 cells are employed in an assay to detect a compound that modulates cholesterol 7.alpha.-hydroxylase enzyme regulation. A method for screening compounds that inhibit or stimulate expression of the enzyme is provided, as well as a method for detecting and isolating transcription factors of the cholesterol 7.alpha.-hydroxylase gene. A transcription factor of 57 KDa is identified which is useful in an assay for determining regulation of CYP7 expression.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: May 19, 1998
    Assignee: Northeastern Ohio University
    Inventor: John Young Ling Chiang
  • Genomic DNA of human cholesterol 7.alpha.-hydroxylase and methods for using it
    Patent number: 5677159
    Abstract: Genomic DNA of cholesterol 7.alpha.-hydroxylase and a minigene are disclosed. The minigene is used for making a transgenic animal that produces functionally active cholesterol 7.alpha.-hydroxylase and functions as a disease model. A cholesterol 7.alpha.-hydroxylase promoter region and reporter gene construct is provided, as well as a transgenic animal that expresses the promoter/reporter gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Northeastern Ohio University
    Inventor: John Young Ling Chiang
  • Transgenic mice expressing human cholesterol 7.alpha.hydroxylase
    Patent number: 5663483
    Abstract: Genomic DNA of cholesterol 7.alpha.-hydroxylase and a minigene are disclosed. The minigene is used for making a transgenic animal that produces functionally active cholesterol 7.alpha.-hydroxylase and functions as a disease model. A cholesterol 7.alpha.-hydroxylase promoter region and reporter gene construct is provided, as well as a transgenic animal that expresses the promoter/reporter gene.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: September 2, 1997
    Assignee: Northeastern Ohio Universities College of Medicine
    Inventor: John Young Ling Chiang
  • Genomic DNA of human cholesterol 7.alpha.-hydroxylase and methods for using it
    Patent number: 5650286
    Abstract: Genomic DNA of cholesterol 7.alpha.-hydroxylase and a minigene are disclosed. The minigene is used for making a transgenic animal that produces functionally active cholesterol 7.alpha.-hydroxylase and functions as a disease model. A cholesterol 7.alpha.-hydroxylase promoter region and reporter gene construct is provided, as well as a transgenic animal that expresses the promoter/reporter gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Northeastern Ohio University
    Inventor: John Young Ling Chiang