Abstract: Chimeric antigen receptor (CAR) with a binding domain that binds STEAP1 are disclosed. The CAR disclosed herein can be used in the treatment of prostate cancer, the Ewing family of tumors (EFT), bladder cancer, ovarian cancer, and rhabdomyosarcoma. The CAR disclosed herein can bind and elicit cytotoxic effects even in low antigen density conditions.

Abstract: The present invention relates to compounds and methods which may be useful as treatments of diseases.

Abstract: Single gate and dual gate FinFET devices suitable for use in an SRAM memory array have respective fins, source regions, and drain regions that are formed from portions of a single, contiguous layer on the semiconductor substrate, so that STI is unnecessary. Pairs of FinFETs can be configured as dependent-gate devices wherein adjacent channels are controlled by a common gate, or as independent-gate devices wherein one channel is controlled by two gates. Metal interconnects coupling a plurality of the FinFET devices are made of a same material as the gate electrodes. Such structural and material commonalities help to reduce costs of manufacturing high-density memory arrays.

Abstract: Polymer catheters and guidewires for use in intravascular surgery, and more particularly polymer catheters and guidewires micro-machined with a micro-cutting machine to provide sufficient flexibility to travel through a patient's vasculature while retaining sufficient torquability to transmit torque from a proximal end to the distal end of the catheter or guidewire, and methods of producing the same.

Abstract: Methods, systems and architectures for video and/or audio processing and distribution are described. More particularly, a just in time transcoder/transcoding (JITT) is employed. If a matching optimal asset segment with calculated optimal asset attributes requested by a client device is not stored in a server, the server is configured to invoke the just in time transcoder (JITT) to produce the matching optimal asset segment by transcoding from one or more assets stored in an asset storage device to fulfill the request of client device.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to detect a presence status. An example apparatus includes media identification circuitry to generate first signatures representative of first audio data associated with a monitored media device, a comparator to obtain second signatures from a portable meter, the second signatures representative of second audio data sensed by the portable meter and compare the first signatures and the second signatures to determine a comparison result, presence detection circuitry to determine a presence status of a user based on the comparison result, the user associated with the portable meter, and network communication circuitry to transmit the presence status to a data processor to perform audience measurement based on the presence status.

Abstract: A fuel injector for an internal combustion engine comprising an injection nozzle comprising a nozzle body with a nozzle bore; a valve needle assembly received within the nozzle bore and including a valve needle engageable with a seat region to control fuel delivery through an outlet of the injection nozzle; and a first actuator arrangement operable to apply an opening force to an engagement region of the valve needle assembly to cause an opening movement thereof. The first actuator arrangement comprises a first conductive coil mounted concentrically on a first body and a first armature configured to apply the opening force to the valve needle assembly. The first body comprises a first, radially inner region having a relatively high magnetic permeability and a second region having a relatively low magnetic permeability, the second region being disposed radially between the first coil and the first, radially inner region.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for intelligently dispatching vehicles to a vehicle service center to progress vehicles at a predefined rate through sequential stations of the vehicle service center. The disclosed systems can analyze services associated with vehicles. Based on the services, the disclosed systems can determine how to order, within a virtual queue, vehicles corresponding to the services. For example, the disclosed systems can predict a complexity associated with a service for a vehicle, and in turn, determine whether adding the vehicle to the service queue will allow the vehicle to move through a set of sequential stations in accordance with the predefined progression rate. In response, the disclosed systems can dispatch the vehicle, refrain from dispatching the vehicle, or otherwise dynamically respond to enable the vehicle to move through the set of sequential stations in accordance with the predefined progression rate.

Abstract: A multi-channel ADC system may include a plurality of input channels coupled to input signals. A multiplexer may couple one or more of the plurality of input channels to one or more multiplexer output channels. A control circuit may be coupled between the multiplexer output channels and an ADC. In operation, a configuration setting may configure the multi-channel ADC system in one of a plurality of configurations, including but not limited to single-ended, differential, pseudo-differential and hybrid configurations. The ADC may convert the plurality of input channels based on the configuration setting.

Abstract: Provided herein are methods for identification of antigen binding molecules such as antibodies from a sample by exposing the antigen binding molecules to an antigen conjugated to an oligonucleotide.

Abstract: A defect detection and ranking system for a vehicle assembly line is provided. The system includes an image capture device that captures a plurality of images of a vehicle on the vehicle assembly line. The system also includes a defect detector that analyzes the plurality of captured images and, based on the analysis, detects a plurality of defects on the surface of the vehicle. Each of the plurality of defects has an associated x-y-z coordinate location, a defect type, and a defect severity. The system also includes a datastore containing a vehicle specification, for the vehicle on the vehicle assembly line, and a defect priority based on the vehicle specification. The system also includes a defect prioritization generator configured to: receive the plurality of defects from the defect detector, retrieve the vehicle specification and the defect priority, and apply the defect priority to the plurality of defects, and output a prioritized list of defects, wherein the prioritized list of defects.

Abstract: A system may include data processing hardware and memory hardware in communication with the data processing hardware. The memory hardware may store instructions that when executed on the data processing hardware cause the data processing hardware to perform operations. The operations include requesting, via a boot manager of a host module, a hardware security module (HSM) to verify an application software of the host module and configuring, via the verified application software, a memory protection unit (MPU) to at least one of no execute and no write for at least one area of a memory of the host module. The operations further include executing the application software with the HSM enabled.

Abstract: A series of orthodontic aligners may be produced by a process including receiving a first position of at least one tooth of a patient for a first treatment stage of plurality of orthodontic treatment stages, determining a movement vector magnitude and direction for moving the at least one tooth from the first position towards a second position, analyzing a surface of the at least one tooth of the patient based on the determined movement vector, designing a first orthodontic aligner of the series of orthodontic aligners based on the analysis of the surface of the at least one tooth of the patient so that a physical orthodontic aligner, when in position on teeth of the patient at the first treatment stage, moves the at least one tooth from the first position towards the second position along the determined movement vector, and fabricating the physical orthodontic aligner.

Abstract: Disclosed are macrocyclic peptide compounds or a salt thereof, which are useful as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds may be useful in treating cancers, inflammatory and autoimmune diseases.

Abstract: A system may include a handling mast, a tubular source stack, a tubing loader, a spider device, and a connection device. The tubing loader is configured to capture a first HVT from the tubular source stack, load the first HVT into the handling mast, capture a second HVT from the tubular source stack, and load the second HVT into the handling mast. The spider device is configured to grasp the first HVT. The connection device is configured to align a proximal end of the first HVT and a distal end of the second HVT and couple the first HVT and the second HVT to form a tubing string. The handling mast is configured to insert the tubing string into the wellbore.

Abstract: Methods and systems of PFAS destruction in water containing nitrate. The methods and systems include filtering water containing PFAS and nitrate through a membrane selective for PFAS to obtain a membrane reject containing PFAS and nitrate and a filtrate containing nitrate, forming a treatment solution using the membrane reject including diluting the membrane reject and combining the membrane reject with a photosensitizer, a sulfite salt, and a sufficient amount of base such that the treatment solution has a pH of about 10 or more, and irradiating the treatment solution with UV light in a photoreactor to destroy a portion of the PFAS. Before dilution, a concentration of PFAS in the membrane reject may be between about 3 times and about 20 times greater than before the filtering step. Dilution of the membrane reject may include between about a 3 and about a 20 times dilution.

Abstract: A glare mitigation accessory that may be easily carried by a person, and which may be easily mounted on readily accessible equipment. The glare mitigation accessory may be a three-sided shade having a roof or top panel with two layers open at one edge and closed at least at portions of the other edges to form a pocket. The readily accessible equipment may be a floppy mounted on a stand. The combined floppy and glare mitigation accessory may be used in a configuration having 0-4 open sides depending on lighting conditions or need for privacy.

Abstract: A low-cost objective lens design uses only ZnS optical material, suitable for use with an uncooled infrared bolometer having a curved focal plane. Its objective lens field of view is at least ±20.0° over a 1280×720 pixel array with 0.0012 mm pitch. Lens chromatic aberrations are corrected over at least the 8-11 micron infrared wavelength band. The objective lens operates at a relatively fast F #/1.0 which is common in the art for bolometer applications.

Abstract: A vaporizer includes a reservoir (or cartridge) to hold a precursor composition. The reservoir has a passageway that is configured to not allow the free flow of the precursor composition out of the reservoir at ambient temperatures. An infrared radiation source, when activated, heats the precursor composition reducing its viscosity. An entrainment passageway is in communication with an exterior end of the passageway such that when an air flow is induced to pass through the entrainment passageway, the air flow draws the heated precursor composition from the passageway entrains it in the air flow. The entrained precursor may be vaporized and/or further vaporized by heat from the infrared radiation source before being inhaled by the user.

Abstract: An accessory mount system is provided for mounting on an aerial work platform having sidewalls extending upwardly from a base to a rim or lip. The mount system is configured to be releasably attached to the lip and one or more of the sidewalls of the work platform and includes quick-connect accessory mounts that allow various types of accessories or accessory mount/holders to be mounted on the system and, via the system, on to the work platform. The system can include a quick-connect mechanism for releasably mounting an accessory to the system. The quick-connect mechanism includes a catch mounted to a frame to pivot between a release position and a lock position and a user actuated release lever connected to the catch to allow a user to actuate the catch from the lock position to the release position.