Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: A method of using microbial methods to form mineral based material elements via the precipitation of calcium-carbonate into an element composed primarily of aggregate is provided. Pressure is applied across at least part of the element being produced in order to drive a bulk flow of a liquid containing nutrients at least partly through the element to the bacteria. Structures in the element may be used to enhance transfer of reagents and nutrients to the microbes within the material.

Abstract: The present disclosure relates to cultured tissue, methods for production of self-sufficient modified cells for producing cultured tissue. Further, the disclosure provides methods of generating cultured meat products without exogenous addition of growth hormones.

Abstract: A serum-free and animal-component-free culture media for expansion of muscle satellite cells is disclosed. The disclosed media can be for use in cultured food applications. The disclosed media can include a baseline serum-free and animal component-free culture media and a recombinant version of albumin. The baseline media, in use, provides a baseline growth capability for expansion of the muscle satellite cells for use in cultured food applications. The disclosed media, in use, provides an improved growth capability for expansion of the muscle satellite cells. The improved growth capability is at least 50% greater than the baseline growth capability. Methods of making and using the disclosed media are also disclosed.

Abstract: The present disclosure relates to cultured adipose tissue. In one embodiment, the cultured adipose tissue is produced by culturing adipose cells in a culture media in vitro, harvesting the adipose cells after a desired amount of adipose cells are produced, and aggregating the harvested adipose cells to provide the cultured adipose tissue. In some embodiments, aggregating the harvested adipose cells comprises mixing the harvested adipose cells with a hydrogel or binder in a three-dimensional (3D) mold. In other embodiments, aggregating the harvested adipose cells comprises cross-linking the harvested adipose cells in a 3D mold. The cultured adipose tissue have a defined 3D shape and a size on the macroscale. In some embodiments, the cultured adipose tissue may be a food product.

Abstract: The present disclosure relates to cultured tissue, methods for production of the cultured tissue, and a bioreactor system for production of the cultured tissue. In some embodiments, the production of the cultured tissue may involve, at a first bioreactor, feeding a fiber scaffold into a chamber containing culture media, seeding the chamber with precursor cells, and allowing the precursor cells to proliferate and differentiate on a surface of the fiber scaffold. At downstream bioreactors, the production of the cultured tissue may further involve twisting a plurality of the cell-laden fibers to provide a cell-laden yarn, and weaving or knitting the cell-laden yarn into a three-dimensional (3D) structure. In some embodiments, the cultured tissue may be whole muscle cultured meat composed of muscle cell-laden fibers and fat cell-laden fibers. The whole muscle cultured meat may have a structural organization and hierarchy that mimics natural skeletal muscle tissue.

Abstract: The present disclosure relates to cultured tissue, methods for production of the cultured tissue, and a bioreactor system for production of the cultured tissue. In some embodiments, the production of the cultured tissue may involve, at a first bioreactor, feeding a fiber scaffold into a chamber containing culture media, seeding the chamber with precursor cells, and allowing the precursor cells to proliferate and differentiate on a surface of the fiber scaffold. At downstream bioreactors, the production of the cultured tissue may further involve twisting a plurality of the cell-laden fibers to provide a cell-laden yarn, and weaving or knitting the cell-laden yarn into a three-dimensional (3D) structure. In some embodiments, the cultured tissue may be whole muscle cultured meat composed of muscle cell-laden fibers and fat cell-laden fibers. The whole muscle cultured meat may have a structural organization and hierarchy that mimics natural skeletal muscle tissue.

Abstract: A biopsy and therapy device comprising: a needling unit for holding and inserting a biopsy needle; an imaging module comprising an ultrasound probe and an actuator for moving the probe in a reciprocal action; a first arcuate slide; a second arcuate slide in sliding engagement with the first arcuate slide and a linkage to which the first arcuate slide is mounted; said linkage arranged to move the first and second arcuate slides within a vertical plane; said needling unit mounted to said arcuate slide wherein the first and second arcuate slides are mounted perpendicular to each other so as to rotate the needling unit about respective first and second principal axes.

Abstract: A biopsy and therapy device comprising: a needling unit for holding and inserting a biopsy needle; an imaging module comprising an ultrasound probe and an actuator for moving the probe in a reciprocal action; a first arcuate slide; a second arcuate slide in sliding engagement with the first arcuate slide and a linkage to which the first arcuate slide is mounted; said linkage arranged to move the first and second arcuate slides within a vertical plane; said needling unit mounted to said arcuate slide wherein the first and second arcuate slides are mounted perpendicular to each other so as to rotate the needling unit about respective first and second principal axes.

Abstract: A configurator is provided that connects with various disparate elements in a telecommunication system. The configurator is adapted to receive a traffic plan that has a plurality of different aspects that are implemented across the disparate elements. The configurator is adapted to generate processing schemas and/or databases that can be used by the disparate elements in order to implement the traffic plan.

Abstract: A configurator is provided that connects with various disparate elements in a telecommunication system. The configurator is adapted to receive a traffic plan that has a plurality of different aspects that are implemented across the disparate elements. The configurator is adapted to generate processing schemas and/or databases that can be used by the disparate elements in order to implement the traffic plan.

Abstract: A photo-electronic air purifying disinfector firstly filters out airborne impurities using a washable filter screen. It then utilizes an activated carbon filter to filter out airborne bacteria and germs. The bacteria and germs which are capable of passing through the activated carbon filter are then eliminated by extreme-UV light emitted by extreme-UV light tubes. It also utilizes a negative ion generator to boost the level of anions in the air before being discharged. These two modes operate in the following manner: the first mode involves cathodic high-voltage output that is discharged via a carbonized fibre. The ionized air is then expelled by a fan. The second mode eliminates bacteria, germs and mould from air as it passes extreme-UV light tubes by exposure to extreme-UV light emitted by these extreme-UV light tubes.

Abstract: A 4-in-1 photo-electronic air conditioning, dehumidifying, purifying and disinfecting system has an activated carbon filter in the first stage to eliminate impurities, germs and bacteria in the air drawn into the system. The bacteria and germs in the extracted air, which are capable of passing through the activated carbon filter, are then eliminated by extreme-UV light emitted by extreme-UV light tubes. The excessive moisture in the air is also removed. A negative ion generator is also used to boost the level of anions in the air. These two modes operate in the following manner: the first mode involves high-voltage cathodic output that is discharged via a carbonized fibre. The ionised air is then expelled by an air drum. The second mode eliminates bacteria, germs and mould from air as it passes extreme-UV light tubes by exposure to extreme-UV light emitted by these extreme-UV light tubes.

Abstract: A 3-in-1 photo-electronic air purifying and disinfecting system, which utilizes alternating current, has an activated carbon filter used in the first stage to eliminate impurities, germs and bacteria in the air drawn into the system. The bacteria and germs which are capable of passing through the activated carbon filter are then eliminated by extreme-UV light emitted by extreme-UV light tubes. An anion generator is also included to boost the level of anions in the air before being discharged. These two modes operate in the following manner: the first mode involves high-voltage cathodic output that is discharged via a carbonized fibre. The ionized air is then expelled by a fan. The second mode eliminates bacteria, germs and mould from air as it passes extreme-UV light tubes by exposure to extreme-UV light emitted by these extreme-UV light tubes.

Abstract: A 4-in-1 photo-electronic air purifying and conditioning system, which utilizes alternating current suitable for use in all weather conditions has activated carbon filters used in the first stage to eliminate impurities, germs and bacteria in the air drawn into the system. The bacteria and germs which are capable of passing through the activated carbon filter are then eliminated by extreme-UV light emitted by extreme-UV light tubes. A negative ion generator is used to boost the level of anions in the air before being discharged. These two modes operate in the following manner: the first mode involves high-voltage cathodic output that is discharged via carbonized fibres. The ionized air is then expelled by a fan. The second mode eliminates bacteria, germs and mould from air as it passes extreme-UV light tubes by exposure to extreme-UV light emitted by these extreme-UV light tubes.

Abstract: A drink-item holding apparatus 5 incorporates an upper flap 53 and a lower flap 54 which may be unfolded from a stowed configuration (FIG. 7) to a deployed configuration (FIG. 8) in which the upper flap 53 is releasably latched in its horizontal position. Projections 532 at the rear edge of the upper flap 53 resiliently push in L-shaped arms 55 against the biasing action of springs 56 until the projections 532 snap past the arms 55 which then serve to latch the upper flap 53 in its deployed configuration. The upper flap 53 may be rotated in the reverse direction in order to unlatch the projections 532 so as to return to the stowed configuration. The upper flap 53 is therefore protected against inadvertent downward rotation. The lower flap 54 folds away upwards, and the upper flap 53 folds away downwards against the lower surface of the lower flap 54 in order to produce a compact arrangement of the apparatus 5.

Abstract: A lantern has a housing with a front end portion, a handle portion and a base portion with an incandescent bulb and a reflector in the front end portion and a fluorescent tube in the base portion. The base portion can be rotated by means of a rotatable joint through 180.degree. so that, using the front end portion as a base, the fluorescent tube can be positioned and angled to give optimum illumination for any particular use.