Abstract: Systems and methods for generating user notifications to a set of users of a social networking service is presented. For each user of a set of users of the social networking service, one or more machine learning models selects an optimal notification channel, an optimal notification template, and optimal personalization content for configurable elements of a selected notification template. Each of these determinations/selections is made according to and based on a likelihood of increased user engagement with the social networking service. Upon determining the notification channel, notification template, and personalizations to the template, the notification is generated and sent to the corresponding user.

Abstract: An overspray-free paint system includes: a paint robot including an overspray-free paint applicator; and a first fixture robot for lifting and orienting a fixture assembly relative to at least one of the paint robot and the overspray-free paint applicator, the fixture assembly configured to hold an object to be painted by the overspray-free paint applicator, the first fixture robot including a first gripper configured to grab a first portion of the fixture assembly, and the first fixture robot configured to lift and orient the fixture assembly via the first gripper.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.

Abstract: Methods, systems, and devices for wireless communication are described. For example, the described techniques provide for a first device (e.g., a cellular modem or user equipment (UE)) mapping quality of service flows of a first radio access technology (e.g., cellular) to service classes of a second RAT (e.g., Wi-Fi). The first device may communicate mapping information that indicates the mapping to a second network device (e.g., a router). The first device and the second device may communicate various packets via the quality of service flows and the service classes.

Abstract: In one aspect, the present disclosure provides compounds such as those with one or more quaternary ammonium ions joined by one or more aromatic rings. These compounds may have a formula: These compounds may be used in the treatment of a microbial infection such as a bacterial infection including infections of drug resistant strains of bacteria.

Abstract: An electronic device may include one or more terminals configured to provide a voltage signal to an actuator. The electronic device may detect a current associated with the voltage signal provided by the terminal to the actuator. The electronic device may determine an impedance across associated with the actuator based on the voltage signal and the electrical current. The electronic device may compare the impedance to a threshold impedance to determine whether there is sufficient skin contact with the actuator. The electronic device may provide audio via cartilage conduction if there is sufficient contact based on comparing the impedance to the threshold impedance, or may output a notification to the user to adjust placement of the electronic device to improve contact.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: An end effector for welding composite components includes an end effector housing and a welding member mounted to the end effector housing. The end effector further includes a leading roller mounted to the end effector housing forward of the welding member and at least one follower roller mounted to the end effector housing aft of the welding member. The end effector further includes at least one first cooling air jet positioned to direct a first stream of cooling air toward the at least one follower roller.

Abstract: Various embodiments of the present disclosure provide a casino patron engagement system that facilitates engagement among casino employees and casino patrons to engender patron loyalty.

Abstract: A three-dimensional printing kit can include a particulate build material with from about 80 wt % to 100 wt % copper-containing build particles having a D50 particle size distribution value from about 1 ?m to about 150 ?m, a binding agent including a build binder to apply to particulate build material layers to form a green body object, and a shaping composition to apply to a surface of the green body object and to control green body object deformation. The shaping composition can include from about 10 wt % to about 80 wt % liquid vehicle and from about 20 wt % to about 90 wt % metal shaping particles having a D50 particle size distribution value from about 100 nm to about 100 ?m. The metal shaping particles can be smaller than the copper-containing build particles.

Abstract: The present application discloses a system and a method for calculating a droplet delay time in a liquid flow of a sorting device, and a sorting device.

Abstract: High-throughput BPF map manipulations with uprobes are disclosed. A method for manipulating a Berkeley Packet Filter (BPF) map comprises running a user program in a user space of a computing environment. The user program includes a trigger function. A corresponding kernel BPF probe is installed by the user program on the trigger function. The kernel BPF probe is triggered by reaching a memory address of the trigger function in the user space. The trigger function includes one or more arguments that the BPF map agent interprets as operation parameters. The BPF map agent performs one or more operations to manipulate a BPF map in the kernel space based on the operation parameters.

Abstract: The present disclosure describes a system with a power management device, a wakeup circuit, a battery management device, and a connector. During a powered down mode of operation, the battery management device can provide, via the connector, a bias voltage to the wakeup circuit. In response to a wakeup switch being activated, the battery management device can provide a power supply (e.g., from a battery) to the power management device. Benefits of the wakeup circuit include (1) a reduction of battery consumption—and thus improving battery lifetime—when the electronic system is in a powered down mode of operation because the wakeup circuit has lower number of active components compared to other designs and (2) a non-complex wakeup circuit design because one or more existing connector interconnects between the power management device and the battery management device can be re-used during electronic system's powered down mode of operation.

Abstract: The present invention relates to the engineering an animal model, preferably mammalian models, more preferably a rat model representing Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in a severe, early-onset axonal neuropathy. A model having the p.Arg364Trp Mfn2 mutation is based on a mutation made using zinc finger endonuclease technology in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized behaviorally and shown to develop multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type rats sacrificed at 7, 40, and 48 weeks and analyzed by light microscopy showed a reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks.

Abstract: Embodiments of the present disclosure provide a method for identifying those entities within a network that have the most influence on other entities within the network. A multi-relational network comprising links among a plurality of physicians is generated based on peer network data, wherein each link indicates a first physician that influences a second physician, and a weight of the influence. A decision by a treating physician of the plurality of physicians is decomposed, using a deep learning engine, into a magnitude of peer influence and a magnitude of control factor influence based on the multi-relational network and a plurality of control factors respectively. The magnitude of peer influence among one or more physicians in the multi-relational network is distributed among physicians in the multi-relational network based on the links each physician maintains with other physicians.

Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.