Patents by Inventor JOHN ZHAO-NIAN LU

JOHN ZHAO-NIAN LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230201231
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.
    Type: Application
    Filed: December 22, 2022
    Publication date: June 29, 2023
    Applicants: AMGEN INC., Atara Biotherapeutics, Inc.
    Inventors: Huiquan HAN, Christopher Michael HAQQ, Isaac CIECHANOVER, Xiaolan ZHOU, John Zhao-Nian LU
  • Patent number: 11541070
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: January 3, 2023
    Assignee: Atara Biotherapeutics, Inc.
    Inventors: Huiquan Han, Christopher Michael Haqq, Isaac Ciechanover, Xiaolan Zhou, John Zhao-Nian Lu
  • Publication number: 20200108085
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 9, 2020
    Inventors: Huiquan HAN, Christopher Michael HAQQ, Isaac CIECHANOVER, Xiaolan ZHOU, John Zhao-Nian LU
  • Publication number: 20150359850
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 17, 2015
    Applicants: SANTA MARIA BIOTHERAPEUTICS, INC., AMGEN INC.
    Inventors: Huiquan Han, Christopher Michael Haqq, Isaac Ciechanover, Xiaolan Zhou, John Zhao-Nian Lu
  • Publication number: 20140294866
    Abstract: The present invention provides methods for treating disorders arising from hypogonadism by administering myostatin antagonists to subjects suffering from such disorders.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 2, 2014
    Inventors: Huiquan Han, Alexander DePaoli, John Zhao-Nian Lu, Jin Lin Wang
  • Publication number: 20140220033
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment by evaluating the subject's expression levels of specific biomarkers or angiogenic factors.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicants: Santa Maria Biotherapeutics, Inc., Amgen Inc.
    Inventors: Huiquan Han, Isaac Ciechanover, Christopher Michael Haqq, Xiaolan Zhou, John Zhao-Nian Lu
  • Publication number: 20110008375
    Abstract: The present invention provides methods for treating disorders arising from hypogonadism, rheumatoid cachexia, cachexia due to burns, cachexia due to administration of chemical agents, cachexia due to diabetes, diabetic nephropathy, Prader Willi syndrome, excessive TNF-?, and other muscle-related, metabolic and inflammatory disorders by administering myostatin antagonists to subjects suffering from such disorders.
    Type: Application
    Filed: September 27, 2010
    Publication date: January 13, 2011
    Inventors: HAN HQ, ALEXANDER DEPAOLI, JOHN ZHAO-NIAN LU, JIN LIN WANG