Patents by Inventor Johnathan A. Napier

Johnathan A. Napier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190323022
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Jörg BAUER, Johnathan A. Napier, Olga Sayanova
  • Patent number: 10351870
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: July 16, 2019
    Assignee: BASF Plant Science Company GmbH
    Inventors: Jörg Bauer, Johnathan A. Napier, Olga Sayanova
  • Patent number: 10208270
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: February 19, 2019
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • Publication number: 20180312888
    Abstract: The invention relates to genetically modified organisms with enhanced production of omega-3 long chain polyunsaturated fatty acids.
    Type: Application
    Filed: June 11, 2018
    Publication date: November 1, 2018
    Inventors: Johnathan A. Napier, Olga Sayanova, Mary Hamilton, Royah Vaezi
  • Publication number: 20170067070
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Application
    Filed: November 15, 2016
    Publication date: March 9, 2017
    Inventors: Jörg Bauer, Johnathan A. Napier, Olga Sayanova
  • Patent number: 9493520
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: November 15, 2016
    Assignee: BASF Plant Science Company GmbH
    Inventors: Jörg Bauer, Johnathan A. Napier, Olga Sayanova
  • Publication number: 20160272951
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Application
    Filed: May 20, 2016
    Publication date: September 22, 2016
    Inventors: Toralf Senger, Laurent MARTY, Sten STYMNE, Jenny LINDBERG YILMAZ, Johnathan A. NAPIER, Olga SAYANOVA, Richard HASLAM, Ruiz Lopez NOEMI
  • Patent number: 9388437
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: July 12, 2016
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • Publication number: 20150275243
    Abstract: The invention relates to genetically modified organisms with enhanced production of omega-3 long chain polyunsaturated fatty acids.
    Type: Application
    Filed: October 1, 2013
    Publication date: October 1, 2015
    Applicant: ROTHAMSTED RESEARCH LIMITED
    Inventors: Johnathan A. Napier, Olga Sayanova, Mary Hamilton, Royah Vaezi
  • Patent number: 9139854
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerin and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: September 22, 2015
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Publication number: 20150216828
    Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
    Type: Application
    Filed: April 12, 2013
    Publication date: August 6, 2015
    Applicant: Rothamsted Research Ltd.
    Inventors: Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
  • Patent number: 8993841
    Abstract: The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: March 31, 2015
    Assignee: BASF Plant Science Company GmbH
    Inventors: Johnathan A. Napier, Olga Sayanova, Frederic Beaudoin
  • Publication number: 20140335579
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerin and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Patent number: 8822662
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: September 2, 2014
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Patent number: 8785727
    Abstract: The present invention relates to a polynucleotide from Emiliana huxleyi which codes for a desaturase and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotide according to the invention, and to the polypeptides encoded by the polynucleotide. The invention furthermore relates to antibodies against the polypeptide according to the invention. Finally, the invention also relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: July 22, 2014
    Assignee: Rothamsted Research Ltd.
    Inventors: Joerg Bauer, Johnathan A. Napier, Olga Sayanova
  • Publication number: 20130097733
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Application
    Filed: June 21, 2011
    Publication date: April 18, 2013
    Applicant: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • Patent number: 8329993
    Abstract: The present invention relates to an improved method for the specific production of unsaturated ?-3 fatty acids and a method for the production of triglycerides having an increased content of unsaturated fatty acids, in particular ?-3 fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, having an increased content of fatty acids, oils or lipids having ?6 double bonds due to the expression of a ?6-desaturase from Primulaceae. The invention additionally relates to expression cassettes containing a nucleic acid sequence, a vector and organisms containing at least one nucleic acid sequence or an expression cassette. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of unsaturated fatty acids and use thereof.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: December 11, 2012
    Assignee: IACR-Rothamsted
    Inventors: Johnathan A. Napier, Olga Sayanova
  • Patent number: 8273958
    Abstract: The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a ?-12-/?-15-desaturase, ?-9-elongase, ?-8-desaturase and a ?-5-desaturase and a process for the production of lipids or oils having an increased content of unsaturated fatty acids, in particular ?-3 and ?-6 fatty acids having at least two double bonds and a 18 or 20 carbon atom chain length. Preferably the arachidonic acid and eicosapentaenoic acid are produced in at least a 1:2 ratio. The invention furthermore relates to the production of a transgenic plants, preferably a transgenic crop plant, having an increased content of arachidonic acid and/or eicosapentaenoic acid, oils or lipids containing C18- or C20-fatty acids with a double bond in position 5, 8, 9, 11, 12, 14, 15 or 17 of the fatty acid produced, respectively due to the expression of the ?-12-/?-15-desaturase, of the ?-9-elongase, of the ?-8-desaturase and of the ?-5-desaturase in the plant.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 25, 2012
    Assignee: BASF Plant Science GmbH
    Inventors: Johnathan A. Napier, Olga Sayanova
  • Patent number: 8258371
    Abstract: The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a ?-12-/?-15-desaturase, ?-9-elongase, ?-8-desaturase and a ?-5-desaturase and a process for the production of lipids or oils having an increased content of unsaturated fatty acids, in particular ?-3 and ?-6 fatty acids having at least two double bonds and a 18 or 20 carbon atom chain length. Preferably the arachidonic acid and eicosapentaenoic acid are produced in at least a 1:2 ratio. The invention furthermore relates to the production of a transgenic plants, preferably a transgenic crop plant, having an increased content of arachidonic acid and/or eicosapentaenoic acid, oils or lipids containing C18- or C20-fatty acids with a double bond in position 5, 8, 9, 11, 12, 14, 15 or 17 of the fatty acid produced, respectively due to the expression of the ?-12-/?-15-desaturase, of the ?-9-elongase, of the ?-8-desaturase and of the ?-5-desaturase in the plant.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 4, 2012
    Assignee: BASF Plant Science GmbH
    Inventors: Johnathan A. Napier, Olga Sayanova
  • Publication number: 20120124705
    Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
    Type: Application
    Filed: July 15, 2010
    Publication date: May 17, 2012
    Applicant: BASF Plant Science Company GMBH
    Inventors: Jörg Bauer, Johnathan A. Napier, Olga Sayanova