Abstract: A method and apparatus for inserting a conventional flexible catheter with a pre-attached connector on the proximal end into a vessel, such as a vein or artery in a cardiovascular system, while monitoring blood pressure. The catheter drive assembly has an external drive input for advancement and retraction of the flexible catheter. The catheter drive assembly has cylindrical catheter drives that can be engaged to or disengaged from the flexible catheter without causing damage to the flexible catheter. The flexible catheter distal end provides fluid communication to a disposable blood pressure transducer. The flexible catheter is completely encapsulated within a protective sleeve and within the catheter drive assembly, creating an aseptic insertion environment, eliminating the need for sterile barrier protection. Once the flexible catheter is inserted to the desired position, the protective sleeve and catheter drive assembly are removed from the flexible catheter leaving the flexible catheter.