Patents by Inventor JOHNATHAN LLOYD KIEL

JOHNATHAN LLOYD KIEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemically programmable immunity
    Patent number: 8604184
    Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: December 10, 2013
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Kary B. Mullis, Jeevalatha Vivekananda, Johnathan Lloyd Kiel, Ronald M. Cook
  • Chemically Programmable Immunity
    Publication number: 20100285052
    Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.
    Type: Application
    Filed: May 5, 2010
    Publication date: November 11, 2010
    Inventors: KARY B. MULLIS, JEEVALATHA VIVEKANANDA, JOHNATHAN LLOYD KIEL, RONALD M. COOK