Patents by Inventor Johnathan W. SMITH
Johnathan W. SMITH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12159776Abstract: Disclosed herein are systems and methods for a mass spectrometer having a multipole configured to pass an ion stream, and a detector configured to detect the properties of the abundance of ions represented by data points. The mass spectrometer also includes a processing system that is configured to obtain a plurality of paired data points (e.g., detector data points and RF amplitude data points), and identify, based on centroiding a portion of the plurality of paired data points, at least one characteristic of a peak and determine, based on the at least one characteristic of the peak, a preferred peak shape.Type: GrantFiled: April 27, 2022Date of Patent: December 3, 2024Assignee: THERMO FINNIGAN LLCInventor: Johnathan W. Smith
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Patent number: 12154774Abstract: A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions.Type: GrantFiled: November 30, 2021Date of Patent: November 26, 2024Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby
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Publication number: 20240347329Abstract: A mass spectrometer support apparatus includes a peak shape logic to determine one or more peak shapes using a calibration mass spectrum and known peak locations; and a tuning logic to adjust instrument parameters to achieve a selected peak width. A method for tuning a quadrupole-based mass spectrometer includes determining one or more peak shapes using a calibration mass spectrum and known peak locations; and adjusting instrument parameters to achieve a selected peak width.Type: ApplicationFiled: April 16, 2024Publication date: October 17, 2024Inventor: Johnathan W. SMITH
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Patent number: 11984307Abstract: A mass spectrometer support apparatus includes a peak shape logic to determine one or more peak shapes using a calibration mass spectrum and known peak locations; and a tuning logic to adjust instrument parameters to achieve a selected peak width. A method for tuning a quadrupole-based mass spectrometer includes determining one or more peak shapes using a calibration mass spectrum and known peak locations; and adjusting instrument parameters to achieve a selected peak width.Type: GrantFiled: January 18, 2022Date of Patent: May 14, 2024Assignee: Thermo Finnigan LLCInventor: Johnathan W. Smith
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Patent number: 11942315Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.Type: GrantFiled: March 3, 2022Date of Patent: March 26, 2024Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Publication number: 20240087862Abstract: A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 ?m; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.Type: ApplicationFiled: November 16, 2023Publication date: March 14, 2024Inventors: Oleg SILIVRA, Alan E. SCHOEN, Johnathan W. SMITH, Berg A. TEHLIRIAN
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Patent number: 11854777Abstract: A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 ?m; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.Type: GrantFiled: July 28, 2020Date of Patent: December 26, 2023Assignee: Thermo Finnigan LLCInventors: Oleg Silivra, Alan E. Schoen, Johnathan W. Smith, Berg A. Tehlirian
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Publication number: 20230352287Abstract: Disclosed herein are systems and methods for a mass spectrometer having a multipole configured to pass an ion stream, and a detector configured to detect the properties of the abundance of ions represented by data points. The mass spectrometer also includes a processing system that is configured to obtain a plurality of paired data points (e.g., detector data points and RF amplitude data points), and identify, based on centroiding a portion of the plurality of paired data points, at least one characteristic of a peak and determine, based on the at least one characteristic of the peak, a preferred peak shape.Type: ApplicationFiled: April 27, 2022Publication date: November 2, 2023Applicant: THERMO FINNIGAN LLCInventor: Johnathan W. SMITH
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Publication number: 20230230823Abstract: A mass spectrometer support apparatus includes a deconvolution logic and a centroider logic. The deconvolution logic is configured to deconvolve a mass spectrum measured by a mass spectrometer using an approximate peak shape. The centroider logic is configured to integrate the deconvolved spectrum and populate a sparse vector of peak locations.Type: ApplicationFiled: January 18, 2022Publication date: July 20, 2023Applicant: THERMO FINNIGAN LLCInventor: Johnathan W. SMITH
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Publication number: 20230230824Abstract: A mass spectrometer support apparatus includes a peak shape logic to determine one or more peak shapes using a calibration mass spectrum and known peak locations; and a tuning logic to adjust instrument parameters to achieve a selected peak width. A method for tuning a quadrupole-based mass spectrometer includes determining one or more peak shapes using a calibration mass spectrum and known peak locations; and adjusting instrument parameters to achieve a selected peak width.Type: ApplicationFiled: January 18, 2022Publication date: July 20, 2023Applicant: THERMO FINNIGAN LLCInventor: Johnathan W. SMITH
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Publication number: 20230005728Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.Type: ApplicationFiled: March 3, 2022Publication date: January 5, 2023Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Publication number: 20220181131Abstract: A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions.Type: ApplicationFiled: November 30, 2021Publication date: June 9, 2022Applicant: THERMO FINNIGAN LLCInventors: Johnathan W. SMITH, Scott T. QUARMBY
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Patent number: 11336290Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole based on an amplifier RF input signal. An analog-to-digital converter (ADC) can generate a digital representation of the RF signal. A controller circuit can receive the digital representation and adjust an amplitude of the amplifier RF input signal based on differences between an amplitude of a fundamental frequency of the RF signal being different than an expected amplitude.Type: GrantFiled: March 30, 2020Date of Patent: May 17, 2022Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Patent number: 11270874Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.Type: GrantFiled: March 30, 2020Date of Patent: March 8, 2022Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Publication number: 20210305991Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole based on an amplifier RF input signal. An analog-to-digital converter (ADC) can generate a digital representation of the RF signal. A controller circuit can receive the digital representation and adjust an amplitude of the amplifier RF input signal based on differences between an amplitude of a fundamental frequency of the RF signal being different than an expected amplitude.Type: ApplicationFiled: March 30, 2020Publication date: September 30, 2021Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Publication number: 20210305035Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.Type: ApplicationFiled: March 30, 2020Publication date: September 30, 2021Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
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Publication number: 20210035789Abstract: A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 ?m; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.Type: ApplicationFiled: July 28, 2020Publication date: February 4, 2021Inventors: Oleg SILIVRA, Alan E. SCHOEN, Johnathan W. SMITH, Berg A. TEHLIRIAN
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Patent number: 10784095Abstract: A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.Type: GrantFiled: December 18, 2018Date of Patent: September 22, 2020Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby
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Publication number: 20200194245Abstract: A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.Type: ApplicationFiled: December 18, 2018Publication date: June 18, 2020Inventors: Johnathan W. SMITH, Scott T. QUARMBY
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Patent number: 9490115Abstract: Techniques are provided for scanning frequency and voltages of a multipole mass filter while maintaining substantially the same number of AC cycles per mass during a scan across a range of masses. For example, a mass spectrum can be obtained by controlling a DC axial voltage that accelerates ions into a mass filter, a DC resolving voltage applied to the mass filter, an AC voltage amplitude applied to the mass filter, and an AC frequency of the AC voltage. The settings can be controlled such that ions of different mass-to-charge ratios are within the mass filter for substantially a same number of AC cycles. To achieve the same number of AC cycles, the AC frequency is changed during the scan. For low masses, a higher AC frequency can be used. For high masses, a lower AC frequency can be used.Type: GrantFiled: December 18, 2014Date of Patent: November 8, 2016Assignee: Thermo Finnigan LLCInventor: Johnathan W. Smith