Abstract: Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

Abstract: A medical retrieval device for retrieving stones, calculi, and the like from various organs and passages may comprising an elongated member, and a first wire and a second wire that forms a retrieval basket. The wires forming the basket and the elongated member may be secured by a crimp joint and a second joint. Processing of the device may include placing all ends of the first wire and the second wire into an elongated member through a distal end of the elongated member, moving said elongated member to a position where the first loop and the second loop start their curvatures, placing said first and second wires and said elongated member through a crimping fixture having thru cuts configured for the interlocked wires, aligning said elongated member in a desired position, and crimping said first and second wires and said elongated member.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

Abstract: A medical retrieval device for retrieving stones, calculi, and the like from various organs and passages may comprising an elongated member, and a first wire and a second wire that forms a retrieval basket. The wires forming the basket and the elongated member may be secured by a crimp joint and a second joint. Processing of the device may include placing all ends of the first wire and the second wire into an elongated member through a distal end of the elongated member, moving said elongated member to a position where the first loop and the second loop start their curvatures, placing said first and second wires and said elongated member through a crimping fixture having thru cuts configured for the interlocked wires, aligning said elongated member in a desired position, and crimping said first and second wires and said elongated member.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use, and methods of manufacturing. In one embodiment, a medical device delivery system may include a body member with a first end having a first outer diameter, a second end having a second outer diameter, an inner surface facing a lumen that extends axially through the body member along a longitudinal axis, and an outer surface opposite to the inner surface. The embodiment also includes a threaded first connector at the first end of the body member. The outer surface of the body member may include a plurality of depressions. The body member may include a first material. The first connector may include a second material. The first material is more flexible than the second material. A portion of the outer surface of the body member may cover a portion of the first connector.

Abstract: A device for guiding an elongate body into a channel of a scope may include a main body extending between a proximal end portion and a distal end portion and a lumen extending through the main body. The device may be slidably attached onto the elongate body such that the elongate body may be threaded through the lumen of the device, out of the distal end portion of the main body of the device, and into the channel of the scope. When a distal end of the elongate body reaches a desired location inside the channel, the device may be moved along the elongate body from a first position to a second position, where the device may be releasably coupled with respect to the elongate body.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

Abstract: Aspects of the invention provides an imaging mini-scope, an attachment clip and a system including these components. Another aspect provides a method to using the imaging scope and attachment clip for an endoscopic procedure. In one embodiment, the mini-scope includes an elongated body having an attached jacket extending to its proximal end to its distal end. The jacket includes a longitudinal track extending from the distal end to the proximal end and defining a lumen having a restricted opening on the external surface of the jacket. The attachment clip includes a head portion that is sized and shaped to fit in the lumen and to slidably engage the longitudinal track.

Abstract: An imaging mini-scope for use with an endoscope system includes an elongated body having a first length. The elongated body includes at least one passage extending along the first length. A flexible distal tip portion is coupled to the elongated body. An imaging device includes an imaging sensor disposed at the flexible distal tip portion and a signal transmission connection extending through the at least one passage to connect the imaging sensor to a processing system. The imaging sensor is configured to detect image information and the signal transmission connection is configured to transmit one or more signals indicative of the detected image information from the imaging sensor to the processing system. A light source is disposed at the flexible distal tip portion. The light source extends through the at least one passage.